Preparation and Characterization of Model Conjugates for the Study of Proteins Modified by ADP-ribose

Modification of proteins by ADP-ribose has been shown to be a versatile modification with respect to the amino acid side chain. The results described here will allow the study of the biological importance of ADP-ribose glycation and also allow differentiation on crude extracts between enzymatic modifications from protein ADP-ribose glycation that can occur due to the presence of NAD glycohydrolases

Method and Use of α-Amino-β-Mercapto-Ethane Derivatives as Dicarbonyl Scavengers for Treatment of Conditions Resulting from Protein, Lipid, and DNA Damage

Methods of inhibiting damage to proteins, lipids, and DNA by the use of penicillamines and other α-amino-β,β-mercapto-β,β-dimethyl-ethane compounds as dicarbonyl scavengers is disclosed