UNDERSTANDING THE MULTIPLE FACETS OF HELICOBACTER PYLORI INFECTION IN CHILDREN

Helicobacter pylori (H. pylori) is a bacterium that colonizes the gastric mucosa and which is known for its ability to survive in the acidic environment of the stomach, thanks to its unique spiral shape and the presence of multiple flagella. Thus, H. pylori infection may present under the shape of multiple clinical entities and understanding its various facets is crucial for effective diagnosis and treatment. The importance of H. pylori infection in children lies in its potential to cause significant morbidity and long-term complications. This article aims to provide an overview of the importance of H. pylori infection in children, including its epidemiology, clinical manifestations, and treatment. Through a better understanding of this common infection, healthcare providers can work towards improving the diagnosis and management of H. pylori infection in children, ultimately improving the long-term health outcomes of affected individuals

Palm-Plant Pain, Sign of a Severe Systemic Disease? Case Report and Review of Literature

Fabry disease is an X-linked lysosomal storage disease, second in prevalence after Gaucher disease. The onset of symptoms occurs in childhood or adolescence with palmo-plantar burning pains, hypo hidrosis, angiokeratomas, and corneal deposits. In the absence of diagnosis and treatment, the disease will progress to the late phase, characterized by progressive cardiac, cerebral and renal damage, and possible death. We present the case of an 11-year-old male boy who was transferred to the Pediatric Nephrology Department for palmo-plantar burning pain and end stage renal disease. Following the evaluations for the etiology of end stage renal disease we excluded the vasculitis, the neurologic diseases, extrapulmonary tuberculosis. Because of suggestive aspect at CT scan and lack of etiologic diagnosis of renal insufficiency we performed lymph node and kidney biopsy, with a surprising result for storage disease. The specific investigation confirmed the diagnosis