A multi-range approach for Cultural Heritage survey: a case study in Mantua Unesco site

In this paper, a Cultural Heritage survey, performed by employing and integrating different type of acquisition technologies (imagebased and active sensor based) is presented. The aim of the survey is to create a 3D multiscale database, therefore, different restitution scales, from the architectural-urban one to a detail one are taken in consideration. This research is part of a project financed by the Unesco for the study of historical gardens located in Mantua and Sabbioneta, and in particular for the Palazzo Te renaissance gardens in Mantua, which are reported in this paper. First of all, a general survey of the area has been realized by employing the classical aerial photogrammetry in order to provide the actual arboreal and urban furniture conditions of the gardens (1:500 scale). Next, a detailed photogrammetric survey of the Esedra courtyard in Palazzo Te has been performed by using a UAV system. At the end, laser scanning and traditional topography have been used for the terrestrial detailed acquisition of gardens and architectural façades (1:50???1:20 scale). The aim of this research is to create a suitable graphical documentation support for the study of the structure of the gardens, to analyze how they have been modified over the years and as an effective support for eventual future re-design. Moreover, the research has involved a certain number of botanic and archeological investigations, which have been duly acquired and modeled with image based systems. Starting from the acquired datasets with their acquisition scales, a series of comparative analysis have been performed, especially for those areas in which all the systems have been employed. The comparisons have been extracted by analyzing point cloud models obtained by using a topographical network. As a result, the multi-range approach efficiency, obtained by employing the actual available technologies have been illustrated in the present work

BIM: An Integrated Model for Planned and Preventive Maintenance of Architectural Heritage

Modern digital technologies give us great possibilities to organize knowledge about constructions, regarding multidisciplinary fields like preservation, conservation and valorization of our architectural heritage, in order to suggest restoration projects and related work, or to suppose a planned preventive maintenance. New procedures to archive, analyze and manage architectural information find a natural support in 3D model, thanks to the development of capacities of new modeling software. Moreover, if the model contains or interfaces with a heterogeneous archive of information, as it is for BIM, this model can be considered as the bases of critical studies, projects of restoration, heritage maintenance, integrated management, protection, and valorization, and evaluation of economic aspects, management and planning, that can flow into a planned preventive maintenance [1]. The aspect that limit the use of BIM technology is the set up parametric object library inside programs: the standardized level of these objects deals difficulty with survey and restoration issues, where each single element has its own historical and architectural characterization [2]. From this foreword, the goal of this research is more evident: the possibilities of using BIM modeling to the existing constructions and cultural heritage, as a support for the construction and management of a Plan for planned preventive maintenance

Hospital patient experiences of contact isolation for antimicrobial resistant organisms in relation to health care–associated infections: A systematic review and narrative synthesis of the evidence

Laura Fregonese - ORCID: 0000-0002-8399-7074 https://orcid.org/0000-0002-8399-7074Background The alarming growth of antimicrobial resistance organisms (AMRs) and the threat caused by health care–associated infections require hospitalized individuals who are infected or colonized with AMRs to be cared for in isolation, predominantly in single rooms. None of the existing reviews focus on or specifically address the patient’s experience of being cared for in contact isolation when affected by AMRs exploring this specific context. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance for the conduct of systematic reviews was applied. Five databases were searched from inception to April 2019, with keywords related to adult patient experiences, AMR, and contact isolation. The evidence was certified by 2 reviewers. Principles of thematic analysis were used to produce a narrative synthesis of the findings. Results Eighteen eligible studies were identified. Narrative synthesis resulted in 3 overarching categories reflecting the patient experience: privacy versus loneliness; emotional responses to isolation; quality of care, recovery, and safety in isolation. Conclusions This review synthesizes existing evidence reflecting the patient experience of contact isolation. Study findings were often contradictory and may not reflect contemporary health care, such as shorter hospital stays, or societal preferences for greater privacy. Further research focusing on contemporary health care contexts is recommended.https://doi.org/10.1016/j.ajic.2023.04.01151pubpub1

PARAMETRIC PARADIGMA: EXCEPTIONAL COFFERED CEILING ARCHITECTURE VS HBIM

The scientific community is confirming the advantages of using BIM in the processes of conservation, management, and intervention over architectural-historical heritage. However, many difficulties remain in the transcription process of elements of the built environment, especially when the objective of the model is to support decision-making processes in restoration operations. Even for apparently simple elements, the procedures are not trivial; the need to define the most adequate operational strategies remains. In the context of this study, a possible approach concerning the documentation of a coffered ceiling has been proposed, a case study which takes into consideration the need to discretize information (to make it effective, transmissible, and understandable) and the potential offered by the combined use of further software automatization

The bust o Francesco II Gonzaga: from digital documentation to 3d printing

Geomatics technics and methods are now able to provide a great contribution to the Cultural Heritage (CH) processes, being adaptable to different purposes: management, diagnosis, restoration, protection, study and research, communication, formation and fruition of the Cultural Heritage. This experimentation was done with an eye to encouraging and promoting the development of principles and good practices for recording, documentation and information management of cultural heritage This research focuses on the documentation path of a cultural asset, in particular a Renaissance statue, aimed to achieve a three dimensional model useful for many digital applications and for solid reproduction. The digital copy can be used in many contexts and represents an efficient tool to preserve and promote CH. It can be included in virtual museum archives and catalogues, shared on network with cultural operators and users, and it permits the contextualization of the asset in its artistic and historical background. Moreover, the possibility to obtain a hard copy, reproduced through 3D printing, allows to reach new opportunities of interaction with CH. In this article, two techniques for the digitization of the terracotta bust of Francesco II Gonzaga, in the City Museum of Mantua, are described: the triangulation scanner and dense image matching photogrammetry. As well as the description of the acquisition and the elaborations, other aspects are taken into account: the characteristics of the object, the place for the acquisition, the ultimate goal and the economic availability. There are also highlighted the optimization pipeline to get the correct three-dimensional models and a 3D printed copy. A separate section discusses the comparison of the realized model to identify the positive and negative aspects of each adopted application

A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators

In this article we analyse the current authorised treatments and trends in early drug development for cystic fibrosis (CF) in the European Union for the time period 2000–2016. The analysis indicates a significant improvement in the innovation and development of new potential medicines for CF, shifting from products that act on the symptoms of the disease towards new therapies targeting the cause of CF. However, within these new innovative medicines, results for CF transmembrane conductance regulator (CFTR) modulators indicate that one major challenge for turning a CF concept product into an actual medicine for the benefit of patients resides in the fact that, although pre-clinical models have shown good predictability for certain mutations, a good correlation to clinical end-points or biomarkers (e.g. forced expiratory volume in 1 s and sweat chloride) for all mutations has not yet been achieved. In this respect, the use of alternative end-points and innovative nonclinical models could be helpful for the understanding of those translational discrepancies. Collaborative endeavours to promote further research and development in these areas as well as early dialogue with the regulatory bodies available at the European competent authorities are recommended

European Respiratory Society International Congress 2017:highlights from the Clinical Assembly

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its six respective groups) that were presented at the 2017 European Respiratory Society International Congress in Milan, Italy. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, the newest research and actual data as well as award-winning abstracts and highlight sessions will be discusse

Clinical highlights from the 2016 European Respiratory Society International Congress

This article contains highlights and a selection of the scientific advances from the European Respiratory Society (ERS) Clinical Assembly (Assembly 1) and its six respective groups (Groups 1.1–1.6) that were presented at the 2016 ERS International Congress in London, UK. The most relevant topics for clinicians will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, diffuse and parenchymal lung diseases, and general practice and primary care. In this comprehensive review, the newest research and actual data will be discussed and put into perspective

Hereditary alpha-1-antitrypsin deficiency and its clinical consequences

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum. The prevalence in Western Europe and in the USA is estimated at approximately 1 in 2,500 and 1 : 5,000 newborns, and is highly dependent on the Scandinavian descent within the population. The most common deficiency alleles in North Europe are PI Z and PI S, and the majority of individuals with severe AATD are PI type ZZ. The clinical manifestations may widely vary between patients, ranging from asymptomatic in some to fatal liver or lung disease in others. Type ZZ and SZ AATD are risk factors for the development of respiratory symptoms (dyspnoea, coughing), early onset emphysema, and airflow obstruction early in adult life. Environmental factors such as cigarette smoking, and dust exposure are additional risk factors and have been linked to an accelerated progression of this condition. Type ZZ AATD may also lead to the development of acute or chronic liver disease in childhood or adulthood: prolonged jaundice after birth with conjugated hyperbilirubinemia and abnormal liver enzymes are characteristic clinical signs. Cirrhotic liver failure may occur around age 50. In very rare cases, necrotizing panniculitis and secondary vasculitis may occur. AATD is caused by mutations in the SERPINA1 gene encoding AAT, and is inherited as an autosomal recessive trait. The diagnosis can be established by detection of low serum levels of AAT and isoelectric focusing. Differential diagnoses should exclude bleeding disorders or jaundice, viral infection, hemochromatosis, Wilson's disease and autoimmune hepatitis. For treatment of lung disease, intravenous alpha-1-antitrypsin augmentation therapy, annual flu vaccination and a pneumococcal vaccine every 5 years are recommended. Relief of breathlessness may be obtained with long-acting bronchodilators and inhaled corticosteroids. The end-stage liver and lung disease can be treated by organ transplantation. In AATD patients with cirrhosis, prognosis is generally grave