A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity.

Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this study, we address the regulatory function of this extension or 'strap' and demonstrate its responsibility for an unusual temperature dependence in ATPase rates. This dependence is a consequence of a thermally sensitive kinetic barrier between the apo 'open' and ATP-bound 'closed' conformations. The strap stabilizes the closed state through trans-protomer interactions. Displacement of cis-protomer contacts from the apo state is rate-limiting for closure and ATP hydrolysis. Strap release is coupled to rotation of the N-terminal domain and dynamics of the nucleotide binding pocket lid. The strap is conserved in higher eukaryotes but absent from yeast and prokaryotes suggesting its role as a thermal and kinetic regulator, adapting Hsp90s to the demands of unique cellular and organismal environments

Sensing bodies:Transdisciplinary enactments of ‘thing-power’ and ‘making-with’ for educational future-making.

Dominant conceptions of education are strongly framed by narratives of ‘power-over’ materials, context, and processes, especially where digital and technological applications reduce complexities between humans, materials, and environments. The separation of knowledge, tools, and bodies in ‘disciplinary bounded’, ‘copyrighted’, and ‘patented’ spaces create a disconnect from our need for sustainable relationships, whereby the future is not given but ‘in-the-making’ (Haraway 2016). Drawing on music and science – as examples of distinct disciplines, often siloed and separated in education – this paper advances nuanced understandings of how post human conceptions of ‘thing-power’1(the power of all bodies including materials) and ‘making-with’ (whereby everything makes each other capable) contribute to the affective encounters of materialities within the classroom. By foregrounding the sensing body as a means to touch and be ‘touched’ by the world, we uniquely contribute to methodologies that illuminate the relational intensity of material sensation as part of coming to ‘know’. In doing so, we engage with the performative work of these materialities and re-define the ‘digital’ beyond the delivery of preplanned learning pathways

Extreme wave events in Ireland: 14 680 BP–2012

The island of Ireland is battered by waves from all sides, most ferociously on the west coast as the first port of call for waves travelling across the Atlantic Ocean. However, when discussing ocean events relevant to the nation of Ire- land, one must actually consider its significantly larger designated continental shelf, which is one of the largest seabed territories in Europe. With this expanded definition, it is not surprising that Ireland has been subject to many oceanic events which could be designated as “extreme”; in this paper we present what we believe to be the first catalogue of such events, dating as far back as the turn of the last ice age

Exploration of a Novel Approach to Measure Brain Smudging in Dancers

Objective Obtain baseline accuracy measurements of right/left discrimination in actively performing dancers without performance-inhibiting injuries. Purpose Gather data that can be used in future studies to expand understanding of brain smudging in dancers. Methods This study is a prognostic cohort study. This study will involve participant use of a simple iPad application to do the left and right discrimination test that is suggested to give information on brain reorganization, or brain smudging Research Problem The specific physical, mental, and emotional demands of dancers’ careers put constant strain on their bodies to perform at the level required and can lead to injury or a higher risk for reinjury. 1,2,3,4Traditional interventions often do not address central consequences of injury on the body, such as motor cortex reorganization, or brain smudging. 5,6The degree of brain smudging that occurs in injured dancers is currently unknown. Ability to discriminate between right and left sides of the body has been proposed as a means of measuring this smudging.7,8,9,1 Results Mean accuracies out of 100 were as follows: right hand was 62.73 (n=22, SD=23.53), left hand was 61.36 (n=22, SD=16.99), right foot was 94.09 (n=22,SD=11.41), and left foot was 91.82 (n=22, SD=14.02). Conclusions The heavier workload that is typically placed on the lower extremities relative to the upper extremities may explain some of the lower accuracy in the hands in this population. 1,2 Further research is needed to establish scores in those with current injuries and determine whether those scores are predictive of future injury

Transdisciplinarity:Re-visioning how science and arts together can enact democratizing creative educational experiences

The movement from STEM to STEAM, with its emphasis on real-world applications, promises to meet the changing needs of a globally connected world. However, the potential of transdisciplinarity to inspire and deepen our understanding of who we are and how we make sense of a world in turmoil remains undertheorized. This article makes a case for repositioning STEAM education as democratized enactments of transdisciplinary education, where arts and sciences are not separate or even separable endeavors. Drawing upon posthumanist theorizing, three projects will exemplify transdisciplinarity across music, mathematics, and science education. Transgressing and transcending disciplinary boundaries, and attending to both human and nonhuman perspectives, we invite a rethink of the work of schools, going beyond democratizing creativity to fully enact posthumanist transdisciplinarity

Will oscillating wave surge converters survive tsunamis?

With an increasing emphasis on renewable energy resources, wave power technology is becoming one of the realistic solutions. However, the 2011 tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed, creating large destructive waves. The question posed here is whether an oscillating wave surge converter (OWSC) could withstand the force of an incoming tsunami. Several tools are used to provide an answer: an analytical 3D model developed within the framework of linear theory, a numerical model based on the non-linear shallow water equations and empirical formulas. Numerical results show that run-up and draw-down can be amplified under some circumstances, leading to an OWSC lying on dry ground

On the modelling of tsunami generation and tsunami inundation

While the propagation of tsunamis is well understood and well simulated by numerical models, there are still a number of unanswered questions related to the generation of tsunamis or the subsequent inundation. We review some of the basic generation mechanisms as well as their simulation. In particular, we present a simple and computationally inexpensive model that describes the seabed displacement during an underwater earthquake. This model is based on the finite fault solution for the slip distribution under some assumptions on the kinematics of the rupturing process. We also consider an unusual source for tsunami generation: the sinking of a cruise ship. Then we review some aspects of tsunami run-up. In particular, we explain why the first wave of a tsunami is sometimes less devastating than the subsequent waves. A resonance effect can boost the waves that come later. We also look at a particular feature of the 11 March 2011 tsunami in Japan—the formation of macro-scale vortices—and show that these macro-scale vortices can be captured by the nonlinear shallow water equations

Me and My VE, Part 4

Virtual environments, augmented reality, serious games, simulations, and other digitally mediated experiences are revolutionizing the way that we work, learn, and interact with people and systems. The employment of these technologies is driving innovation in research, training, education, evaluation, and various business endeavors. This session will provide a brief overview of some of the diverse uses of virtual environments (VEs) in an alternate demonstration format that leaves just over half of the session time for hands on, interactive demonstrations. Unlike most demonstration sessions, where possible, we encourage session attendees to personally interact with the demonstrations. The session will begin with demonstrators providing a brief description of their VE and how they’ve used it to address a unique need. At the conclusion of the description portion of the session, each VE will be set up at a demonstration station in the room, and session attendees are encouraged to engage with both the demonstrations for a hands on interaction with the VE and with the demonstrators to get more information about the development and use of the VE, and stimulate discussion on how the concepts, methods, and tools can be used to solve additional problems or business needs

Large Scale Structure traced by Molecular Gas at High Redshift

We present observations of redshifted CO(1-0) and CO(2-1) in a field containing an overdensity of Lyman break galaxies (LBGs) at z=5.12. Our Australia Telescope Compact Array observations were centered between two spectroscopically-confirmed z=5.12 galaxies. We place upper limits on the molecular gas masses in these two galaxies of M(H_2) <1.7 x 10^10 M_sun and <2.9 x 10^9 M_sun (2 sigma), comparable to their stellar masses. We detect an optically-faint line emitter situated between the two LBGs which we identify as warm molecular gas at z=5.1245 +/- 0.0001. This source, detected in the CO(2-1) transition but undetected in CO(1-0), has an integrated line flux of 0.106 +/- 0.012 Jy km/s, yielding an inferred gas mass M(H_2)=(1.9 +/- 0.2) x 10^10 M_sun. Molecular line emitters without detectable counterparts at optical and infrared wavelengths may be crucial tracers of structure and mass at high redshift.Comment: 4 pages, accepted for publication in ApJ Letter