The effect of outlines, headings and summaries on the recall of informational text

The purpose of this study was to investigate various text-based ways of assisting Year Seven readers to enhance their recall of informational texts. The theory that was tested in this investigation is that text-based reading aids which secure the activation and rehearsal of relevant form and/or content schemata for written texts will enhance the recall of the content and structure of those texts. To investigate the comparative impact of the text conditions, 105 Year Seven students from a large primary school in a northern suburb of the Perth Metropolitan Area were ranked on the basis of their reading comprehension scores. They were systematically assigned to each of the five groups to create five approximately heterogeneous groups thus creating a stratified sample. Two separate experiments were conducted. The dependent variable for the first was the recall of content, while for the second, it was the ability to show a knowledge of the text’s structure. It was concluded that, for this sample of Year Seven students, the quantity of content recalled was enhanced to about the same significant degree by the use of in-text headings or the use of a pre-text outline when compared with the no text-based aids condition. Further, it was concluded that the use of in-text headings and a pre-text outline enhanced the recall of text content about as well as the use of in-text headings, a pre-text outline and a post-text summary. Both produced significantly enhanced recall when compared with the no text-based aids condition the in-text headings condition and the pre-text outline condition. As a result of experiment two, it was concluded that the recall of text structure was not enhanced by the use of in-text headings. It was further concluded that the use of a pre-text outline, the use of a pre-text outline with in-text headings, and the use of a pre-text outline with in-text headings and a post-text summary produced equal scores on the recall of text structure. All three of these conditions produced significantly enhanced recall of text structure when compared with the no text-based aids condition and the in-text headings condition. Since the pre-text outline was the variable common to all of these conditions, it was concluded that the use of a pre-text outline had a significant, beneficial effect upon the recall of text structure. It is clear from the findings of this study that the recall of the content and structure of informational texts by Year Seven students, like those in the sample used in this study could be significantly enhanced if texts were produced with carefully formulated pre-text outlines and in-text headings

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia

Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown. In vitro studies suggest hydroxyurea could increase malaria severity, and hydroxyurea-associated neutropenia could worsen infections. NOHARM (Novel use Of Hydroxyurea in an African Region with Malaria) was a randomized, double-blinded, placebo-controlled trial conducted in malaria-endemic Uganda, comparing hydroxyurea to placebo at 20 ± 2.5 mg/kg per day for 12 months. The primary outcome was incidence of clinical malaria. Secondary outcomes included SCA-related adverse events (AEs), clinical and laboratory effects, and hematological toxicities. Children received either hydroxyurea (N = 104) or placebo (N = 103). Malaria incidence did not differ between children on hydroxyurea (0.05 episodes per child per year; 95% confidence interval [0.02, 0.13]) vs placebo (0.07 episodes per child per year [0.03, 0.16]); the hydroxyurea/placebo malaria incidence rate ratio was 0.7 ([0.2, 2.7]; P = .61). Time to infection also did not differ significantly between treatment arms. A composite SCA-related clinical outcome (vaso-occlusive painful crisis, dactylitis, acute chest syndrome, splenic sequestration, or blood transfusion) was less frequent with hydroxyurea (45%) than placebo (69%; P = .001). Children receiving hydroxyurea had significantly increased hemoglobin concentration and fetal hemoglobin, with decreased leukocytes and reticulocytes. Serious AEs, sepsis episodes, and dose-limiting toxicities were similar between treatment arms. Three deaths occurred (2 hydroxyurea, 1 placebo, and none from malaria). Hydroxyurea treatment appears safe for children with SCA living in malaria-endemic sub-Saharan Africa, without increased severe malaria, infections, or AEs. Hydroxyurea provides SCA-related laboratory and clinical efficacy, but optimal dosing and monitoring regimens for Africa remain undefined. This trial was registered at www.clinicaltrials.gov as #NCT01976416

Multiwavelength transit observations of the candidate disintegrating planetesimals orbiting WD 1145+017

We present multiwavelength, ground-based follow-up photometry of the white dwarf WD 1145+017, which has recently been suggested to be orbited by up to six or more short-period, low-mass, disintegrating planetesimals. We detect nine significant dips in flux of between 10% and 30% of the stellar flux in our ~32 hr of photometry, suggesting that WD 1145+017 is indeed being orbited by multiple, short-period objects. Through fits to the asymmetric transits that we observe, we confirm that the transit egress is usually longer than the ingress, and that the transit duration is longer than expected for a solid body at these short periods, all suggesting that these objects have cometary tails streaming behind them. The precise orbital periods of the planetesimals are unclear, but at least one object, and likely more, have orbital periods of ~4.5 hr. We are otherwise unable to confirm the specific periods that have been reported, bringing into question the long-term stability of these periods. Our high-precision photometry also displays low-amplitude variations, suggesting that dusty material is consistently passing in front of the white dwarf, either from discarded material from these disintegrating planetesimals or from the detected dusty debris disk. We compare the transit depths in the V- and R-bands of our multiwavelength photometry, and find no significant difference; therefore, for likely compositions, the radius of single-size particles in the cometary tails streaming behind the planetesimals must be ~0.15 μm or larger, or ~0.06 μm or smaller, with 2σ confidence

Line Broadening in Field Metal-poor Red Giant and Red Horizontal Branch Stars

We report 349 radial velocities for 45 metal-poor field red giant and red horizontal branch stars. We have have identified one new spectroscopic binary, HD 4306, and one possible such system, HD 184711. We also report 57 radial velocities for 11 of the 91 stars reported on previously by Carney et al. (2003). As was found in the previous study, radial velocity "jitter" is present in many of the most luminous stars. Excluding stars showing spectroscopic binary orbital motion, all 7 of the red giants with M(V) <= -2.0 display jitter, as well as 3 of the 14 stars with -2.0 <= M(V) <= -1.4. We have also measured line broadening in all of the new spectra, using synthetic spectra as templates. The most luminous red giants show significant line broadening, as do many of the red horizontal branch stars, and we discuss briefly possible causes.Comment: To appear in the Astronomical Journa

Multiwavelength Transit Observations of the Candidate Disintegrating Planetesimals Orbiting WD 1145+017

We present multiwavelength, multi-telescope, ground-based follow-up photometry of the white dwarf WD 1145+017, that has recently been suggested to be orbited by up to six or more, short-period, low-mass, disintegrating planetesimals. We detect 9 significant dips in flux of between 10% and 30% of the stellar flux from our ground-based photometry. We observe transits deeper than 10% on average every ~3.6 hr in our photometry. This suggests that WD 1145+017 is indeed being orbited by multiple, short-period objects. Through fits to the multiple asymmetric transits that we observe, we confirm that the transit egress timescale is usually longer than the ingress timescale, and that the transit duration is longer than expected for a solid body at these short periods, all suggesting that these objects have cometary tails streaming behind them. The precise orbital periods of the planetesimals in this system are unclear from the transit-times, but at least one object, and likely more, have orbital periods of ~4.5 hours. We are otherwise unable to confirm the specific periods that have been reported, bringing into question the long-term stability of these periods. Our high precision photometry also displays low amplitude variations suggesting that dusty material is consistently passing in front of the white dwarf, either from discarded material from these disintegrating planetesimals or from the detected dusty debris disk. For the significant transits we observe, we compare the transit depths in the V- and R-bands of our multiwavelength photometry, and find no significant difference; therefore, for likely compositions the radius of single-size particles in the cometary tails streaming behind the planetesimals in this system must be ~0.15 microns or larger, or ~0.06 microns or smaller, with 2-sigma confidence.Comment: 16 pages, 12 figures, submitted to ApJ on October 8th, 201

Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content

© 2016 The Author(s). Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection responsible for thousands of deaths in children in sub-Saharan Africa. CM pathogenesis remains incompletely understood but a number of effectors have been proposed, including plasma microparticles (MP). MP numbers are increased in CM patients' circulation and, in the mouse model, they can be localised within inflamed vessels, suggesting their involvement in vascular damage. In the present work we define, for the first time, the protein cargo of MP during experimental cerebral malaria (ECM) with the overarching hypothesis that this characterisation could help understand CM pathogenesis. Using qualitative and quantitative high-throughput proteomics we compared MP proteins from non-infected and P. berghei ANKA-infected mice. More than 360 proteins were identified, 60 of which were differentially abundant, as determined by quantitative comparison using TMT TM isobaric labelling. Network analyses showed that ECM MP carry proteins implicated in molecular mechanisms relevant to CM pathogenesis, including endothelial activation. Among these proteins, the strict association of carbonic anhydrase I and S100A8 with ECM was verified by western blot on MP from DBA/1 and C57BL/6 mice. These results demonstrate that MP protein cargo represents a novel ECM pathogenic trait to consider in the understanding of CM pathogenesis

A Survey of Proper Motion Stars. XVII. A Deficiency of Binary Stars on Retrograde Galactic Orbits and the Possibility that omega Centauri is Related to the Effect

We find a deficiency of binary stars moving on strongly retrograde Galactic orbits. No binary deficiencies are seen for U or W velocities, however. From theoretical analyses, we rule out preferential disruption of pre-existing binary stars due to encounters with massive perturbers. We also rule out globular clusters as the source of the effect since prograde motions are more likely to create such an effect. We search for star streams and find one possible candidate, but it is not on a retrograde orbit and probably represents the remains of a cluster that has passed too near the Galactic center. Based on a very small number of stars, we find that about the right fraction of stars on retrograde Galactic orbits share some chemical similarities to the cluster omega Cen, suggesting that its parent galaxy could be the explanation.Comment: To appear in the Astronomical Journal (March 2005 issue

Multiwavelength Transit Observations of the Candidate Disintegrating Planetesimals Orbiting WD 1145+017

We present multiwavelength, ground-based follow-up photometry of the white dwarf WD 1145+017, which has recently been suggested to be orbited by up to six or more short-period, low-mass, disintegrating planetesimals. We detect nine significant dips in flux of between 10% and 30% of the stellar flux in our ~32 hr of photometry, suggesting that WD 1145+017 is indeed being orbited by multiple, short-period objects. Through fits to the asymmetric transits that we observe, we confirm that the transit egress is usually longer than the ingress, and that the transit duration is longer than expected for a solid body at these short periods, all suggesting that these objects have cometary tails streaming behind them. The precise orbital periods of the planetesimals are unclear, but at least one object, and likely more, have orbital periods of ~4.5 hr. We are otherwise unable to confirm the specific periods that have been reported, bringing into question the long-term stability of these periods. Our high-precision photometry also displays low-amplitude variations, suggesting that dusty material is consistently passing in front of the white dwarf, either from discarded material from these disintegrating planetesimals or from the detected dusty debris disk. We compare the transit depths in the V- and R-bands of our multiwavelength photometry, and find no significant difference; therefore, for likely compositions, the radius of single-size particles in the cometary tails streaming behind the planetesimals must be ~0.15 μm or larger, or ~0.06 μm or smaller, with 2σ confidence