873 research outputs found
Data Analysis and Neuro-Fuzzy Technique for EOR Screening : Application in Angolan Oilfields
This study is sponsored by the Angolan National Oil Company (Sonangol EP) and the authors are grateful for their support and the permission to use the data and publish this manuscriptPeer reviewedPublisher PD
From the polling booths to the courtrooms : challenges of strict application of time frame in judicial contestation of election disputes in Nigeria
After her longest military interregnum spanning almost two decades since 1984, Nigeria returned to a democratic system of government in May 1999. By May 2019, five presidential and other national and sub-national elections were held in the country. Virtually all of these elections were characterized by intense political strives and electoral malpractices of varying degrees, leading to the challenging of elections in the election petition tribunals and other courts, long after the conclusion of the polls. This challenge has heightened the spate of judicialization of politics-the practice of excessive utilization of the courts for adjudication of core political matters in the country. But a significant by-product of judicialization of politics in Nigeria is the apparent relegation of substantial justice and possible miscarriage of justice arising from a resort to a technicality in the strict interpretation and enforcement of time frame for such adjudications. This paper, using a doctrinal research methodology of relying on primary and secondary sources of information, shows that the current strict interpretation of the constitutional provisions on the time limit for adjudication of electoral disputes defeats the essence of substantial justice and impacts negatively on the role of the judiciary in social engineering. For comparative constitutional purposes, the paper also juxtaposes the practice in Kenya, another country in Africa with electoral disputation experiences, with the practice in Nigeria. The paper concludes that a review of the law is imperative and then makes somerecommendations
Histomorphology of germ cell tumors at various anatomic sites: a 5 years study at a tertiary care centre
Background: Germ cell tumors (GCTs) are a heterogeneous group of neoplasms, which occur in the gonads, and at extra gonadal sites of the body. The aim of the study was to observe the different histopathological patterns of various GCTs in the body at all possible sites and to know their IHC staining patterns.Methods: The study was conducted for a period of 5 years from 2015 to 2019 and was an observational study. The recorded data was compiled and entered in a spreadsheet and then exported to data editor of SPSS Version 20.0. Continuous variables were expressed as mean SD and categorical variables were summarized as frequencies and percentages. Graphically the data was presented by bar and pie diagrams Chi-square test or Fisher’s exact test was applied for comparing categorical values. P<0.05 was considered statistically significant. All p values were 2 tailed.Results: A total of 93 cases were analyzed and the mean age of the patients was 27.8 years. Mature cystic teratoma was the most common histopathological variant and was mostly seen in the ovaries. There was a difference in age predilection of benign and malignant tumors. Most of the malignant GCTs were gonadal while EGCTs were likely to be benign. MGCTs (mixed GCTs) were mostly testicular in origin with only one MGCT being extragonadal.Conclusions: Mature cystic teratomas were the most frequent GCTs with frequent site being in ovaries. Out 0f 18 EGCTs only 2 were malignant, rest all were mature cystic teratomas.
Application of artificial intelligence for technical screening of enhanced oil recovery methods
Acknowledgment This study is sponsored by the Angolan National Oil Company (Sonangol EP) and the authors are grateful for their support and the permission to use data and publish this manuscript.Peer reviewedPublisher PD
Effect of Adding Lycopene to the Ration in some Blood Traits of Broiler Ross 308
This study was conducted at Poultry Farm of Animal Resources Dept., College of Agriculture, University of AL-Qasim Green to investigate the effect of adding Lycopene to the ration in some blood traits of broiler Ross 308 . Use the 90 broiler chicks Ross 308 day-old were randomly assigned to three treatments (by 3 replicates per treatment 10 chicks per replicate), and treatments were as follows : ( first treatment) without adding lycopene to the diet, add lycopene by 250 mg / kg feed (second treatment) and add lycopene by 500 mg / kg feed ( Third treatment) . Blood traits included in this study were red and white blood cell counts, hematocrit, hemoglobin concentration and differential leucocyte count . The results indicated that the addition of lycopene by 250 and 500 mg / kg feed to broiler diet led to a significant improvement) p<0.05( in red and white blood cell counts, hematocrit and hemoglobin concentration and significant decrease) p<0.05 (in heterophil to lymphocyte ratio .It concluded from this experience, that the addition of lycopene by 250 and 500 mg / kg feed to the ration can lead to improve in some blood traits of the broiler . Keywords : lycopene , blood traits , broile
In-silico studies of HMG-Co A reductase inhibitors present in fruits of Withania coagulans Dunal (Solanaceae)
Purpose: To evaluate the antihypercholesterolemic effect of chemical constituents of W. coagulans by determining inhibitory effect of the compounds against HMG-CoA reductase, using in-silico methods.
Method: Docking simulations of twenty-one chemical constituents, found in the fruits of W. coagulans were performed against HMGCR(PDB ID: 2Q1L) using Molegro Virtual Docker software. The best docked poses were then selected, based on the docking score and amino acids involved in the interaction within the ligand and active site of protein.
Results: Five compounds viz. Coagulin D (comp no. 11), Ergosta-5,25-diene-3β,24ε-diol (comp no. 13), Withacoagulin (comp no. 15), and Withaferin (comp no. 16), showed the highest MolDock scores. These compounds with highest docking score, also formed hydrogen bond interactions with His (752), Lys (692, 735), Asp (690), Glu (559) within the binding site of HMG-CoA reductase, thus, halting enzyme activity. Whereas, Withanolide D (comp no. 17) with high MolDock score did not show hydrogen bonding interactions.
Conclusion: The high MolDock score and maximum binding with catalytic region of the enzyme indicate that compounds selected from the fruits of W. coagulans are potential blockers of HMG-CoA reductase. Thus, the compounds may be useful for the management of hypercholesterolemia, which untreated, often leads to coronary artery disease.
Keywords: Withania coagulans, Coronary artery disease, HMG-CoA reductase, Molegro virtual docker, Hypercholesterolemia, In silico studie
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