Une approche pour l'amélioration de la qualité au CHU de Liège.

Présentation du concept de déclaration informatisée d'événement indésirable

Fasciola hepatica: An assessment of the vectorial capacity of Radix labiata and R. balthica commonly found in Belgium

A previous study in Belgium revealed that genetic material of Fasciola sp. was present in four local snail species: Galba truncatula, Radix peregra, Radix ovata and Lymnaea stagnalis. Laboratory cultures of these four species were experimentally infected with F. hepatica. The collected metacercariae were fed to rats and the infection in that vertebrate hosts was monitored through several techniques. The mortality rates in the breeding unit was less than 10 % in G. truncatula, R. peregra, and L. stagnalis colonies. Microscopy revealed the presence of larval stages in 78.3 % and 48 % of G. truncatula and R. peregra snails, respectively. These data were confirmed by a PCR that amplifies a parasite specific sequence. R. peregra shed fewer metacercariae and more irregularly than G. truncatula. In R. ovata and L. stagnalis the infection rates were low. Specific DNA was detected in both cases by PCR but no metacercariae were shed. The metacercariae shed by R. peregra were as infective to rats as those from G. truncatula. The PCR technique was more sensitive than microscopic examination. This study demonstrated that R. peregra may act as an accidental intermediate host for F. hepatica in Belgium

Thinking differently about health care after COVID-19

peer reviewed: La crise sanitaire liée à la pandémie du coronavirus (COVID-19) a obligé la société, et les hôpitaux en particulier, à s’adapter et se réformer. Le travail en équipe entre hôpitaux, même au-delà des réseaux, a permis de faire face à la crise. Le corps médical et infirmier a dû apprendre à travailler différemment et faire la distinction entre les soins urgents et non urgents. Mais le patient aussi a dû changer ses comportements. L’accès aux hôpitaux s’est vu diviser entre un trajet COVID et non-COVID, bien distincts, afin d’éviter des contaminations. La télémédecine est devenue un moyen quotidien de communiquer entre le monde médical et les patients. Des consultations téléphoniques ont été instaurées avec, à la clef, un remboursement par l’INAMI. Cependant, ces actions et innovations ne devraient pas se terminer avec la crise liée à la COVID-19, mais, au contraire, être un levier pour repenser le rôle des hôpitaux, et notre système de soins de santé plus globalementThe health crisis linked to the coronavirus pandemic (COVID-19) has forced society and hospitals in particular to adapt and reform. Teamwork between hospitals, even beyond the networks, helped them to deal with the crisis. The medical and nursing staff had to learn to work differently and differentiate urgent from non-urgent care. But the patient also had to change his/her behaviour. Access to hospitals has been divided between a separate COVID and non-COVID route in order to avoid contamination. Telemedicine has become a daily way of communicating between doctors and patients. Telephone consultations have been set up with reimbursement by social security. However, these actions and innovations should not end with the crisis but, on the contrary, be a lever to rethink the role of hospitals, and our health care system more generally

Immune response and antigen recognition in non-pregnant ewes experimentally infected with Neospora caninum tachyzoites.

The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes developed specific lymphoproliferative and humoral responses within 2 weeks post-infection (PI). The magnitude of the cellular response showed large variations between animals. A significant decrease in the proliferative response to Con A mitogen and N. caninum, Toxoplasma gondii (TG) antigens was recorded on day 21 post-infection (PI). The humoral response and the pattern of antigen recognition were similar among infected ewes. Proteins of 44, 42, 40, 39 and 28 kDa were intensively recognized by the infected animals during the experiment. The 42 and 28 kDa antigens should be considered as useful for the diagnostic of N. caninum infection, as the intensity of recognition infection of the other antigens had decreased markedly 8 weeks post-infection. For some antigens a sequential recognition was recorded. The 59, 54 and 38-37 kDa proteins were frequently recognized by infected sera during the first weeks of the infection, but recognition of these antigens was absent or rare at the end of the experiment. These antigens could be related to the acute stage of the infection