Organic field-testing of compounds to control apple scab (Venturia inaequalis) in combination with alleyway cover crops

To find new potential fungicides acceptable to organic production preventing apple scab (Venturia inaequalis) infections on leaf and fruits during primary apple scab infection period. The trials were carried out in combination with different cover crop treatments in single-tree plots. The formerly resistant variety ‘Delorina’ on rootstock M9, planted 1995 at a planting distance of 3.3 m x 1.6 m, unfertilized and with mechanical weed cleaning in the tree row, were used. The experimental orchard is located at Research Centre Aarslev (100 27´ E, 550 18´N)

Differential Effects of Falcarinol and Related Aliphatic C17-Polyacetylenes on Intestinal Cell Proliferation

Quantitative major polyacetylenes of carrots (falcarinol and falcarindiol) and American ginseng roots (falcarinol and panaxydol) were isolated and tested in human intestinal epithelial cells of normal (FHs 74 Int.) and cancer (Caco-2) origin. A hormesis effect was seen for all isolated polyacetylenes when added to Caco-2 cells in concentrations ranging from 1 ng/mL to 20 μg/mL. The relative inhibitory potency was falcarinol > panaxydol > falcarindiol. No hormesis effect was observed when adding the polyacetylenes to FHs 74 Int. cells. Instead, an inhibitory growth response was observed above 1 μg/mL. The relative inhibitory potency was panaxydol > falcarinol > falcarindiol. Maximal inhibition at 20 μg/mL corresponded to approximately 95% and 80% inhibition of cell proliferation in normal and cancer cells, respectively. Combinations of falcarinol and falcarindiol added to normal and cancer cells showed a synergistic response for the inhibition of cell growth. Furthermore, the oxidized form of falcarinol, falcarinon, showed a significantly less growth inhibitory effect in intestinal cells of both normal and cancer origin; hence, a hydroxyl group at C-3 may be important for activity of falcarinol-type polyacetylenes. Extracts of carrots, containing different amounts of falcarinol, falcarindiol, and falcarindiol 3-acetate had significant inhibitory effects on both normal and cancer cell proliferation. In cancer cells, the extract containing the highest concentration of falcarinol tended to have the highest growth inhibitory effect, in accordance with a higher potency of falcarinol than falcarindiol. The present study demonstrates that aliphatic C17-polyacetylenes are potential anticancer principles of carrots and related vegetables and that synergistic interaction between bioactive polyacetylenes may be important for their bioactivity

Receiver Architectures for MIMO-OFDM Based on a Combined VMP-SP Algorithm

Iterative information processing, either based on heuristics or analytical frameworks, has been shown to be a very powerful tool for the design of efficient, yet feasible, wireless receiver architectures. Within this context, algorithms performing message-passing on a probabilistic graph, such as the sum-product (SP) and variational message passing (VMP) algorithms, have become increasingly popular. In this contribution, we apply a combined VMP-SP message-passing technique to the design of receivers for MIMO-ODFM systems. The message-passing equations of the combined scheme can be obtained from the equations of the stationary points of a constrained region-based free energy approximation. When applied to a MIMO-OFDM probabilistic model, we obtain a generic receiver architecture performing iterative channel weight and noise precision estimation, equalization and data decoding. We show that this generic scheme can be particularized to a variety of different receiver structures, ranging from high-performance iterative structures to low complexity receivers. This allows for a flexible design of the signal processing specially tailored for the requirements of each specific application. The numerical assessment of our solutions, based on Monte Carlo simulations, corroborates the high performance of the proposed algorithms and their superiority to heuristic approaches