141 research outputs found
Simulation-based training for colonoscopy:establishing criteria for competency
The aim of this study was to create simulation-based tests with credible pass/fail standards for 2 different fidelities of colonoscopy models. Only competent practitioners should perform colonoscopy. Reliable and valid simulation-based tests could be used to establish basic competency in colonoscopy before practicing on patients. Twenty-five physicians (10 consultants with endoscopic experience and 15 fellows with very little endoscopic experience) were tested on 2 different simulator models: a virtual-reality simulator and a physical model. Tests were repeated twice on each simulator model. Metrics with discriminatory ability were identified for both modalities and reliability was determined. The contrasting-groups method was used to create pass/fail standards and the consequences of these were explored. The consultants significantly performed faster and scored higher than the fellows on both the models (Pâ<â0.001). Reliability analysis showed Cronbach Îąâ=â0.80 and 0.87 for the virtual-reality and the physical model, respectively. The established pass/fail standards failed one of the consultants (virtual-reality simulator) and allowed one fellow to pass (physical model). The 2 tested simulations-based modalities provided reliable and valid assessments of competence in colonoscopy and credible pass/fail standards were established for both the tests. We propose to use these standards in simulation-based training programs before proceeding to supervised training on patients
Automatic and unbiased assessment of competence in colonoscopy:exploring validity of the Colonoscopy Progression Score (CoPS)
Background and aims: Colonoscopy is a difficult procedure to master. Increasing demands for colonoscopy, due to screening and surveillance programs, have highlighted the need for competent performers. Valid methods for assessing technical skills are pivotal for training and assessment. This study is the first clinical descriptive report of a novel colonoscopy assessment tool based on Magnetic Endoscopic Imaging (MEI) data and the aim was to gather validity evidence based on the data collected using the âColonoscopy Progression Scoreâ (CoPS). Methods: We recorded 137 colonoscopy procedures performed by 31 endoscopists at three university hospitals. The participants performed more than two procedures each (range 2âââ12) and had an experience of 0âââ10â000 colonoscopies. The CoPS was calculated for each recording and validity was explored using a widely accepted contemporary framework. The following sources of validity evidence were explored: response process (data collection), internal structure (reliability), relationship to other variables (i.âe. operator experience), and consequences of testing (pass/fail). Results: Identical set-ups at all three locations ensured uniform data collection. The Generalizability coefficient (G-coefficient) was 0.80, and a Decision-study (D-study) revealed that four recordings were sufficient to ensure a G-coefficient above 0.80. We showed a positive correlation between CoPS and experience with Pearsonâs r of 0.61 (Pâ<â0.001). A pass/fail standard of 107 points was established using the contrasting group method to explore the consequences of testing. Conclusion: This study provides evidence supporting the validity of the CoPS for use in assessing technical colonoscopy performance in the clinical setting. Study registration: NCT01997177
Thoracic epidural analgesia reduces gastric microcirculation in the pig
BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig. METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30Â min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI). RESULTS: As assessed by LSCI 15Â min following TEA, gastric arteriolar flow decreased by 22Â % at the antrum (pâ=â0.020) and by 19Â % at the corpus (pâ=â0.029) of the stomach. In parallel, the microcirculation decreased by 19Â % at the antrum (pâ=â0.015) and by 20Â % at the corpus (pâ=â0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30Â min following induction of TEA (pâ=â0.048). These manifestations took place along with a drop in systolic blood pressure (pâ=â0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate. CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans. TRIAL REGISTRATIONS: Not applicable, non-human study
Effect of hospital-admission volume on outcomes following acute non-variceal upper gastrointestinal bleeding
Plasma pro-atrial natriuretic peptide to estimate fluid balance during open and robot-assisted esophagectomy:a prospective observational study
Abstract
Background
It remains debated how much fluid should be administered during surgery. The atrial natriuretic peptide precursor proANP is released by atrial distension and deviations in plasma proANP are reported associated with perioperative fluid balance. We hypothesized that plasma proANP would decrease when the central blood volume is compromised during the abdominal part of robot-assisted hybrid (RE) esophagectomy and that a positive fluid balance would be required to maintain plasma proANP.
Methods
Patients undergoing RE ( n \u2009=\u200925) or open (OE; n \u2009=\u200925) esophagectomy for gastroesophageal cancer were included consecutively in this prospective observational study. Plasma proANP was determined repetitively during esophagectomy to allow for distinction between the abdominal and thoracic part of the procedure. The RE group was 15\ub0 head up tilted during the abdominal procedure.
Results
The blood loss was 250 (150\u2013375) (RE) and 600\ua0ml (390\u2013855) (OE) ( p \u2009=\u20090.01), but the two groups of patients were provided with a similar positive fluid balance: 1705 (1390\u20131983) vs. 1528\ua0ml (1316\u20131834) ( p \u2009=\u20090.4). However, plasma proANP decreased by 21% ( p \u2009<\u20090.01) during the abdominal part of RE carried out during moderate head-up tilt, but only by 11% ( p \u2009=\u20090.01) during OE where the patients were supine. Plasma proANP and fluid balance were correlated in the RE-group ( r \u2009=\u20090.5 (0.073\u20130.840), p \u2009=\u20090.02) and tended to correlate in the OE group ( r \u2009=\u20090.4 (\u22120.045\u20130.833), p \u2009=\u20090.08).
Conclusion
The results support that plasma proANP decreases when the central blood volume is compromised and suggest that an about 2200\ua0ml surplus administration of crystalloid is required to maintain plasma proANP during esophagectomy.
Trial registration
Clinicaltrials.gov ( NCT02077673 ). Registered retrospectively February 12
th
2014
Plasma pro-atrial natriuretic peptide to estimate fluid balance during open and robot-assisted esophagectomy:a prospective observational study
BACKGROUND: It remains debated how much fluid should be administered during surgery. The atrial natriuretic peptide precursor proANP is released by atrial distension and deviations in plasma proANP are reported associated with perioperative fluid balance. We hypothesized that plasma proANP would decrease when the central blood volume is compromised during the abdominal part of robot-assisted hybrid (RE) esophagectomy and that a positive fluid balance would be required to maintain plasma proANP. METHODS: Patients undergoing RE (nâ=â25) or open (OE; nâ=â25) esophagectomy for gastroesophageal cancer were included consecutively in this prospective observational study. Plasma proANP was determined repetitively during esophagectomy to allow for distinction between the abdominal and thoracic part of the procedure. The RE group was 15° head up tilted during the abdominal procedure. RESULTS: The blood loss was 250 (150â375) (RE) and 600 ml (390â855) (OE) (pâ=â0.01), but the two groups of patients were provided with a similar positive fluid balance: 1705 (1390â1983) vs. 1528 ml (1316â1834) (pâ=â0.4). However, plasma proANP decreased by 21% (pâ<â0.01) during the abdominal part of RE carried out during moderate head-up tilt, but only by 11% (pâ=â0.01) during OE where the patients were supine. Plasma proANP and fluid balance were correlated in the RE-group (râ=â0.5 (0.073â0.840), pâ=â0.02) and tended to correlate in the OE group (râ=â0.4 (â0.045â0.833), pâ=â0.08). CONCLUSION: The results support that plasma proANP decreases when the central blood volume is compromised and suggest that an about 2200 ml surplus administration of crystalloid is required to maintain plasma proANP during esophagectomy. TRIAL REGISTRATION: Clinicaltrials.gov (NCT02077673). Registered retrospectively February 12(th) 2014
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
Effects of glepaglutide, a novel long-acting glucagon-like peptide-2 analogue, on markers of liver status in patients with short bowel syndrome:findings from a randomised phase 2 trial
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