A <i>Saccharomyces cerevisiae</i> model and screen to define the functional consequences of oncogenic histone missense mutations

AbstractSomatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations predominantly occur in the histone H3.