Mechanisms of stretch-mediated skin expansion at single-cell resolution.

The ability of the skin to grow in response to stretching has been exploited in reconstructive surgery1. Although the response of epidermal cells to stretching has been studied in vitro2,3, it remains unclear how mechanical forces affect their behaviour in vivo. Here we develop a mouse model in which the consequences of stretching on skin epidermis can be studied at single-cell resolution. Using a multidisciplinary approach that combines clonal analysis with quantitative modelling and single-cell RNA sequencing, we show that stretching induces skin expansion by creating a transient bias in the renewal activity of epidermal stem cells, while a second subpopulation of basal progenitors remains committed to differentiation. Transcriptional and chromatin profiling identifies how cell states and gene-regulatory networks are modulated by stretching. Using pharmacological inhibitors and mouse mutants, we define the step-by-step mechanisms that control stretch-mediated tissue expansion at single-cell resolution in vivo.Wellcome Trust Royal Societ

Physiopathology of the androgen receptor in prostate cancer.

info:eu-repo/semantics/nonPublishe

Androgen receptor mutations in prostate cancer

info:eu-repo/semantics/nonPublishe

Therapeutic applications of skin stem cells

info:eu-repo/semantics/publishe

Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.

info:eu-repo/semantics/publishe

Hair follicle stem cells and interfollicular epidermis are competent to initiate squamous skin tumors

info:eu-repo/semantics/nonPublishe

Transcriptional activities of a carboxy-terminal end truncated mutant androgen receptor :Impact on prostate cancer progression.

info:eu-repo/semantics/nonPublishe