ORGANIZATION OF MEDICAL AID DURING ANTHRAX OUTBREAK IN YAMALO-NENETS AUTONOMOUS DISTRICT IN 2016

The efficiency and timeliness of medical care of infectious patients are largely determined by the promptness of diagnosis and the rational organization of medical sorting of patients and contact persons. In 2016 there were 36 anthrax cases in the Yamal. In the immediate area of the epidemic were 327 people, including 135 children, in the endangered area – 539 people, including 217 children. Organization of medical care for patients and contact persons was accompanied by objective difficulties associated with the vastness of the territory under threat of infection spread, the presence of atypical and rare clinical forms of anthrax. Тhe article presents the analysis of actions for rendering of medical aid to patients with anthrax in the Yamal in 2016, and the proposed algorithms in medical triage and the organization of the emergency unit

CLINICAL FEATURES OF ANTHRAX MANIFESTATIONS IN YAMALO-NENETS AUTONOMOUS DISTRICT IN 2016

36 cases of human infection with anthrax, manifested in various clinical forms, were registered in the territory of Yamalo-Nenets Autonomous District in 2016. Cutaneous anthrax was characterized by emergence of carbuncle, however objective difficulties of clinical diagnostics, associated with atypicality of clinical manifestations (erysipeloid form of the disease, crusting) were outlined. Clinical manifestations of oropharyngeal anthrax were severe febrile reaction, intoxication, edema of subcutaneous fat on face and neck, and lesions of mucous membranes. Intestinal anthrax was diagnosed in one patient and characterized by the acute onset followed by faintness, loss of appetite, vomiting, and abdominal pain. Based on the results of carried out investigations, put forward were the measures on optimization of approaches to clinical diagnostics of anthrax

Хитозан и дезоксикрахмал в качестве полимерных матриц для иммобилизации биологически активных компонентов

Introduction in structure of drugs carbohydrate components lead to increasing solubility in water, detoxication and prolongation of biological action in organism. Method of synthesis polymeric forms of isoniazid include reaction oligochitosan, N-hydroxymethylchitosan and N-chloro-2- hydroxypropylchitozan with antiphthisic substance. Hydrophilic polymeric base of streptomycin sulfate was prepared by reactions chitosan with antibiotics sulfate. Synthesized water-soluble analogues of 1,4-β-2-amino-2-desoxy-D-glucan with side chains containing amino acids with the formation of covalent linkage through methylene or hydroxypropylene spacer. As a polymer matrix for the immobilization of glycine, L-lysine and its hydrochloride, L-glutamic acid used chitosan, Nhydroxymethylchitosan, N-chloro-2-hydroxypropylchitosan and 3-hydroxymethyl-3-deoxy-starch.Химическая модификация лекарственных веществ углеводами приводит к значительному снижению вредного побочного действия на организм и увеличению биодоступности. Проведена разработка способов иммобилизации изониазида и стрептомицина в структуру гомологов хитозана с образованием соответствующих ковалентных связей. Синтезированы водорастворимые аналоги 1,4-β-2-амино-2-дезокси-D- глюкана и 1,4-α-D-глюкана с боковыми цепями, содержащими компоненты α-аминокислот с образованием ковалентных связей через метилен- или гидроксипропилен-спейсеры. В качестве полимерных матриц для иммобилизации глицина, L-лизина гидрохлорида, L- глутаминовой кислоты использовались N-гидроксиметилхитозан, N-хлор-2- гидроксипропилхитозан и гидроксиметил-3-дезоксикрахмал

Chitosan and deoxy-starch as polymeric matrixes for immobilization of bioactive components

Introduction in structure of drugs carbohydrate components lead to increasing solubility in water, detoxication and prolongation of biological action in organism. Method of synthesis polymeric forms of isoniazid include reaction oligochitosan, N-hydroxymethylchitosan and N-chloro-2- hydroxypropylchitozan with antiphthisic substance. Hydrophilic polymeric base of streptomycin sulfate was prepared by reactions chitosan with antibiotics sulfate. Synthesized water-soluble analogues of 1,4-β-2-amino-2-desoxy-D-glucan with side chains containing amino acids with the formation of covalent linkage through methylene or hydroxypropylene spacer. As a polymer matrix for the immobilization of glycine, L-lysine and its hydrochloride, L-glutamic acid used chitosan, Nhydroxymethylchitosan, N-chloro-2-hydroxypropylchitosan and 3-hydroxymethyl-3-deoxy-starch