3 research outputs found
In vivo Study of the Layered Structure on the Abdomen by Broadband Time-Domain Diffuse Optical Spectroscopy
We investigate the effect of depth heterogeneity in the abdomen by multidistance time-domain diffuse optical spectroscopy on 4 volunteers finding a higher water content in shallower regions, possibly due to fat heterogeneity and/or dermis contributions
Multidistance time domain diffuse optical spectroscopy in the assessment of abdominal fat heterogeneity
A periodic monitoring of the adipose tissue functions due to interventions, such as calorie restriction and bariatric surgery, or pathophysiological processes, has an increasing relevance in clinical diagnostics. Diffuse Optical Spectroscopy (DOS) is a valuable non-invasive tool that can be used in that direction. In this work, we present a pilot study based on Time Domain Broadband Diffuse Optical Spectroscopy (TD DOS) to characterize in vivo the subcutaneous fat tissue in the abdominal region. A first of its kind, portable TD DOS instrumentation, already enrolled in clinical studies, was used. Three healthy male volunteers were considered. Three source-detector separation distances (1, 2, and 3 cm) were used over the broad wavelength range of 600-1100 nm. The analysis was performed using a method based on a heterogeneous model to account for the multi-layered nature of the subcutaneous adipose tissue, and to obtain the optical properties specific to this fat localization. Inter-subject variation of tissue composition data was observed
A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise
Performance assessment and standardization are indispensable for instruments of clinical relevance in general and clinical
instrumentation based on photon migration/diffuse optics in particular. In this direction, a multi-laboratory exercise was
initiated with the aim of assessing and comparing their performances. 29 diffuse optical instruments belonging to 11 partner
institutions of a European level Marie Curie Consortium BitMap were considered for this exercise. The enrolled
instruments covered different approaches (continuous wave, CW; frequency domain, FD; time domain, TD and spatial
frequency domain imaging, SFDI) and applications (e.g. mammography, oximetry, functional imaging, tissue
spectroscopy). 10 different tests from 3 well-accepted protocols, namely, the MEDPHOT, the BIP, and the nEUROPt
protocols were chosen for the exercise and the necessary phantoms kits were circulated across labs and institutions enrolled
in the study. A brief outline of the methodology of the exercise is presented here. Mainly, the design of some of the
synthetic descriptors, (single numeric values used to summarize the result of a test and facilitate comparison between
instruments) for some of the tests will be discussed.. Future actions of the exercise aim at deploying these measurements
onto an open data repository and investigating common analysis tools for the whole datase