18 research outputs found
Clinical practice: The bleeding child. Part II: Disorders of secondary hemostasis and fibrinolysis
Bleeding complications in children may be caused by disorders of secondary hemostasis or fibrinolysis. Characteristic features in medical history and physical examination, especially of hemophilia, are palpable deep hematomas, bleeding in joints and muscles, and recurrent bleedings. A detailed medical and family history combined with a thorough physical examination is essential to distinguish abnormal from normal bleeding and to decide whether it is necessary to perform diagnostic laboratory evaluation. Initial laboratory tests include prothrombin time and activated partial thromboplastin time. Knowledge of the classical coagulation cascade with its intrinsic, extrinsic, and common pathways, is useful to identify potential defects in the coagulation in order to decide which additional coagulation tests should be performed
Evaluation of activated partial thromboplastin time coagulation waveform analysis for identification of patients with acquired factor VIII inhibitors
Novel missense mutation in the coagulation factor IX catalytic domain associated with severe haemophilia B - Factor IXDelhi
Clinical utility and impact of the use of the chromogenic vs one‐stage factor activity assays in haemophilia A and B
Hemextin AB complex - A snake venom anticoagulant protein complex that inhibits factor VIIa activity
10.1159/000092420Pathophysiology of Haemostasis and Thrombosis344-5184-187PHTA