4 research outputs found
Daily oral pamidronate in women and men with osteoporosis: a 3-year randomized placebo-controlled clinical trial with a 2-year open extension
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2002
- Field of study
The efficacy and safety of oral pamidronate was examined in a double-blind, placebo-controlled trial in women and men with established osteoporosis. Seventy-eight postmenopausal women and 23 men with at least one prevalent vertebral fracture were randomized separately to 150 mg/day of pamidronate or placebo for 3 years followed by 150 mg/day of pamidronate for an additional 2 years. In addition, all patients received 400 U/day of cholecalciferol and 500 mg/day of elemental calcium. Pamidronate increased significantly bone mineral density of the lumbar spine (LS-BMD) and of the femoral neck (FN-BMD). The total increase in BMD of the spine after 5 years of treatment was 14.3%. Lateral spine radiographs were obtained at baseline and after 3 years of treatment. Fractures of previously normal vertebrae occurred in 15 of 45 patients treated with placebo (33.3%) and in 5 of 46 patients treated with pamidronate (11%). The relative risk was 0.33 (95% CI, 0.14-0.77). Treatment was well tolerated and there was no difference in gastrointestinal toxicity between pamidronate and placebo-treated patients. One hundred fifty milligrams daily of pamidronate is an effective and safe treatment of women and men with established osteoporosi
Daily Oral Pamidronate in Women and Men With Osteoporosis: A 3-Year Randomized Placebo-Controlled Clinical Trial With a 2-Year Open Extension
- Author
- Adachi
- Aeilko H. Zwinderman
- Bijvoet
- Black
- Black
- Boivin
- Boutsen
- Bravenboer
- Caroline Brumsen
- Cummings
- Delmas
- Eastell
- Eggelmeijer
- Ernest K. J. Pauwels
- Eugene V. Mccloskey
- Frijlink
- Fromm
- Guyatt
- Harinck
- Harris
- Hoekman
- J. Coen Netelenbos
- Jan C. Roos
- Jan Otto Landman
- Karpf
- Lees
- Lufkin
- McCloskey
- McCloskey
- McClung
- Meunier
- Neveen A. T. Hamdy
- Orwoll
- Papapoulos
- Papapoulos
- Paul Lips
- Petronella H. L. M. Geelhoed-Duijvestijn
- Pols
- Reginster
- Reginster
- Reid
- Reid
- Reid
- Rob M. Valentijn
- Ryan
- Saag
- Socrates E. Papapoulos
- Storm
- Thiebaud
- Tonino
- Valkema
- van Beek
- Van Breukelen
- Van Holten-Verzantvoort
- Watts
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Towards a common semantics for english count and mass nouns
- Author
- Adrian Akmajian
- Alice Meulen ter
- Anna Maria Sciullo Di
- Arnold Lobel
- Bertrand Russell
- Brendan S. Gillen
- Brendan S. Gillon
- Carl Lee Baker
- Cornelis Hendrik Bunt
- D. Terence Langendoen
- Dietmar Zaefferer
- Elisabeth O. Selkirk
- Francis J. Pelletier
- Francis J. Pelletier
- Fred Landman
- Fred Landman
- Gareth Evans
- Gareth Evans
- Greg Carlson
- Greg Carlson
- H. Clark
- Helen Cartwright
- Helen Cartwright
- Irene Heim
- Irving Copi
- James C. Abbott
- James D. McCawley
- James Higginbotham
- James Higginbotham
- Jan Tore Lønning
- Janet Dean Fodor
- Lauri Carlson
- Otto Jesperson
- Peter Lasersohn
- Peter Roeper
- Peter Simons
- Randolph Quirk
- Ray Jackendoff
- Robin J. Wilson
- Rochelle Lieber
- Terence Parsons
- Willard V. Quine
- Wilson Follett
- Zeno Vendler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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