17 research outputs found
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2
Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity
A common protein fold and similar active site in two distinct families of β-glycanases
International audienceThe structure of Clostridium thermocellum endoglucanase CelC, a member of the largest cellulase family (family A), has been determined at 2.15 A resolution. The protein folds into an (alpha/beta)8 barrel, with a deep active-site cleft generated by the insertion of a helical subdomain. The structure of the catalytic core of xylanase XynZ, which belongs to xylanase family F, has been determined at 1.4 A resolution. In spite of significant differences in substrate specificity and structure (including the absence of the helical subdomain), the general polypeptide folding pattern, architecture of the active site and catalytic mechanism of XynZ and CelC are similar, suggesting a common evolutionary origin