Inertial waves and modes excited by the libration of a rotating cube

We report experimental measurements of the flow in a cubic container submitted to a longitudinal libration, i.e. a rotation modulated in time. Velocity fields in a vertical and a horizontal plane are measured in the librating frame using a corotating particle image velocimetry system. When the libration frequency $\sigma_0$ is smaller than twice the mean rotation rate $\Omega_0$, inertial waves can propagate in the interior of the fluid. At arbitrary excitation frequencies $\sigma_0<2\Omega_0$, the oscillating flow shows two contributions: (i) a basic flow induced by the libration motion, and (ii) inertial wave beams propagating obliquely upward and downward from the horizontal edges of the cube. In addition to these two contributions, inertial modes may also be excited at some specific resonant frequencies. We characterize in particular the resonance of the mode of lowest order compatible with the symmetries of the forcing, noted [2,1,+]. By comparing the measured flow fields to the expected inviscid inertial modes computed numerically [L.R.M. Maas, Fluid Dyn. Res. \textbf{33}, 373 (2003)], we show that only a subset of inertial modes, matching the symmetries of the forcing, can be excited by the libration.Comment: Phys. Fluids (in press

Damping inertial modes excitation in a closed grid turbulence experiment under rotation

We report an experimental study of the decay of grid-generated turbulence in a confined geometry submitted to a global rotation. Turbulence is generated by rapidly towing a grid in a parallelepipedic water tank. The velocity fields of a large number of independent decays are measured in a vertical plane parallel to the rotation axis using a corotating Particle Image Velocimetry system. We first show that, when a “simple” grid is used, a significant amount of the kinetic energy (typically 50%) is stored in a reproducible flow composed of resonant inertial modes. The possible coupling between these modes and turbulence suggests that turbulence cannot be considered as freely decaying in this configuration. We demonstrate however that these inertial modes may be significantly reduced (down to 15% of the total energy) by adding a set of inner tanks attached to the grid. These results suggest that it is possible to produce an effectively freely decaying rotating turbulence in a confined geometry

Alterations in Ca2+ Signalling via ER-mitochondria contact site remodelling in cancer

Inter-organellar contact sites establish microdomains for localised Ca2+-signalling events. One of these microdomains is established between the ER and the mitochondria. Importantly, the so-called mitochondria-associated ER membranes (MAMs) contain, besides structural proteins and proteins involved in lipid exchange, several Ca2+-transport systems, mediating efficient Ca2+ transfer from the ER to the mitochondria. These Ca2+ signals critically control several mitochondrial functions, thereby impacting cell metabolism, cell death and survival, proliferation and migration. Hence, the MAMs have emerged as critical signalling hubs in physiology, while their dysregulation is an important factor that drives or at least contributes to oncogenesis and tumour progression. In this book chapter, we will provide an overview of the role of the MAMs in cell function and how alterations in the MAM composition contribute to oncogenic features and behaviours