Evaluation des Bereichs Forschung und Entwicklung im Bundesprogramm Ökologischer Landbau

In 2010, the BLE commissioned an evaluation of the Federal Organic Farming Scheme (BÖL), running since 2001. This paper reports on the approach taken in the evaluation of its research component, selected findings, and recommendations. An impact model of the BÖL scheme was developed to analyse how the various measures could contribute to the scheme’s overall aims and objectives. Data from the BLE research project database were analysed to assess the distribution of resources over time by topic and by research provider. At project level, a random selection of 83 projects was reviewed by external experts, including both scientists and other stakeholders to assess their quality and relevance. An online survey of 104 project leaders and interviews with 30 sector stakeholders and 12 BLE employees were carried out and the theme identification and project selection processes were analysed to evaluate whether the programme management contribute was in line with programme goals. The overall conclusions of the evaluation were then reviewed by external experts. The evaluation concludes that financed projects resulted in a compendium of easily accessible results. The research is relevant to the sector and this is one of the greatest strengths of the programme. However, the consistently high allocation of resources to crops and soil themes is noted as a weakness. A more strategic approach to the identification of research targets and to the development of impact from research outputs with appropriate measures at both programme and project level is recommended

Weed suppression and tolerance in winter oats

A crops ability to both suppress weed growth and tolerate weed competition is a key consideration when taking an agroecological approach to weed management. Amongst other cereals, oats are widely considered to have superior weed competitiveness yet studies examining competitive ability between oat varieties are rare. We investigated the ability of oats to suppress weeds and yield in the presence of competition from weeds in trials involving five husked and three naked oat varieties at an organic site in the east of England over four trial years (2009-13). We identified a number of key traits that were important for weed suppression including establishment rates, tillering ability, and early Leaf Area Index (LAI) which highlight the importance of rapid early growth rates. Furthermore, taller varieties tended to be more weed tolerant but not necessarily more suppressive. Trade-offs between competitive traits and yield were not found in this study. Crop tillering ability was highlighted as an important trait for selection due to its beneficial effects on weed suppression as well as grain yield and also its high heritability

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

GSK2126458 (GSK458) is a potent inhibitor of PI3K (α, β, γ, and δ), with preclinical studies demonstrating broad antitumor activity. We performed a first-in-human phase I study in patients with advanced solid tumors

Phase I study of GSK461364, a specific and competitive Polo-like Kinase 1 (PLK1) inhibitor in patients with advanced solid malignancies.

Purpose: GSK461364 is an ATP-competitive inhibitor of polo-like kinase 1 (Plk1). A phase I study of two schedules of intravenous GSK461364 was conducted. Experimental Design: GSK461364 was administered in escalating doses to patients with solid malignancies by two schedules, either on days 1, 8, and 15 of 28-day cycles (schedule A) or on days 1, 2, 8, 9, 15, and 16 of 28-day cycles (schedule B). Assessments included pharmacokinetic and pharmacodynamic profiles, as well as marker expression studies in pretreatment tumor biopsies. Results: Forty patients received GSK461364: 23 patients in schedule A and 17 in schedule B. Dose-limiting toxicities (DLT) in schedule A at 300 mg (2 of 7 patients) and 225 mg (1 of 8 patients) cohorts included grade 4 neutropenia and/or grade 3-4 thrombocytopenia. In schedule B, DLTs of grade 4 pulmonary emboli and grade 4 neutropenia occurred at 7 or more days at 100 mg dose level. Venous thrombotic emboli (VTE) and myelosuppression were the most common grade 3-4, drug-related events. Pharmacokinetic data indicated that AUC (area under the curve) and C-max (maximum concentration) were proportional across doses, with a half-life of 9 to 13 hours. Pharmacodynamic studies in circulating tumor cells revealed an increase in phosphorylated histone H3 (pHH3) following drug administration. A best response of prolonged stable disease of more than 16 weeks occurred in 6 (15%) patients, including 4 esophageal cancer patients. Those with prolonged stable disease had greater expression of Ki-67, pHH3, and Plk1 in archived tumor biopsies. Conclusions: The final recommended phase II dose for GSK461364 was 225 mg administered intravenously in schedule A. Because of the high incidence (20%) of VTE, for further clinical evaluation, GSK461364 should involve coadministration of prophylactic anticoagulation. Clin Cancer Res; 17(10); 3420-30. (C ) 2011 AACR

Organic farming as a rational choice: Empirical investigations in environmental decision making

Based on a postal survey of farmers conducted in 2004 in Western Germany (n = 657), a rational choice model of the adoption of organic farming is tested. Using methods of direct utility measurement, rational choice (RC) theory is applied directly in the empirical study. By that, questionable assumptions on the variability of preferences and the type of preferences to use in RC explanations can be avoided. The results indicate that the subjectively expected utility model is well suited to explain the adoption of organic farming. Expectations on the development of operational characteristics of the farm and farmers’ daily work are at the core of the decision. Farmers especially consider aspects like pest and weed control, the development of yields or the use of chemical substances. While solely economic factors like prices and marketing are also important, these are subordinate to operational aspects. In addition, a moderate impact of environmental concern regarding the adoption of organic farming is observed. (author's abstract