An evaluation of orthodox and emerging alternative approaches to the industrial policy in the context of economic development

In a broad sense, an industrial policy is aimed at influencing the structure of an economy. Justin Lin (2010), argues that the best way to upgrade a country’s endowment structure is to develop its industries according to the comparative advantages determined by its given endowment structure at that time. Then he assumes that the economy would be most competitive, the economic surplus predominant, and the capital accumulation and the upgrading of factor endowment structure will be the fastest possible. He further proposes that the private enterprises should enter industries according to the country’s comparative advantages, relative factor prices must fully reflect the relative abundance of those factors as prices can only be determined through competition in a ―well-functioning‖ market. Therefore, the market should be the basic institution of the economy. The proposed essay will conduct a critical analysis of structuralism and industrial policy as propagated within the ―New Structural Economics‖ realm as proposed by Justin Lin, a former World Bank chief economist. The proposed inquiry would attempt to underline that the Newly Industrialised Countries showed that specific institutions have performed a critical role in guiding market forces towards industrial development. Notably is the state as an institution in its developmental role in guiding economic strategy and industrial policies. Therefore, the basic argument is that despite the eminence of the orthodox economic approach and its responses to the recent economic crises there are numerous contradictions, including weaknesses as advocated by Lin’s approach to developmental issues and the role of industrial policy, expressly with regard to the developing world

The poverty of a theology of the poor: an althusserian exposure of the philosophical basis of Latin American theology of liberation

The emergence of Latin American theology of liberation was inspired by vistas exposed by a Marxian analysis of society and international power relations. This fact is attested to not only by critical analysts of liberation theology but by liberation theologians themselves. For the latter, the attestati on of this fact is backed by deliberate attempts at applying a sele ct io n of fundamental aspects of Marxist theory to theological discourse. The resultant methodological orientation this imposes on liberation theology, namely, a practicalmaterialist accent, is highlig ht ed as a feature which distinguishes liberation theology from its antecedent traditional Christian theology, and which expressly establishes its so cio-political utility as a theology for the liberation of the poor from historical forms of oppression.This study is a critical historico-philosophical evaluation of this relationship between Latin American theology of liberation and Marxist Theory. Drawing from Louis Althusser’s per spective on Marxism, it reveals that the former is formulated upon a systematic failure to recognise the method ological-epistemological implications of Karl Marx’s rejection of the humanist materialism of the philosophy of Ludwig Feuerbach during and after 1845.In this way, liberation theology is exposed as being trapped into a pre-Marxian Feuerbachian epistemological framework, which in some major respects, incorporates precritical elements of the philosophy of G.W.F. Hegel as expressed in the pre-1845 writings of Karl Marx. In corroboration of this, similarities between the fundamental Feuerbachian epistemological presuppositions and liberation theology are identified. The conclusion defended is that, instead of being Marxist in its underlying philosophical orientation, as its proponents claim it to be, liberation theology is essentially Feuerbachian. As such, its usefulness in the struggle for the liberation of the poor and oppressed from capitalist domination is found as being extremely limited

Dentinogenic Ghost Cell Tumour, a rare case of an African young female patient: Review of literature and report of a case

Dentinogenic ghost cell tumour (DGCT) is a very rare aggressive benign odontogenic tumour with high recurrence rate and a potential to transform into malignancy. It can render facial disfigurement. The tumour is most frequently encountered in males than females with a ratio of 2:1. The peak incidence is in patients aged 40 - 60 years and the posterior mandible is slightly more affected than the maxilla. Segmental resection is a recommended surgical treatment and long-term postsurgical follow up is essential. This paper discusses a case of a 20-year-old African female patient who was diagnosed with a DGCT

Variable gap device and method of manufacture

A variable gap device which comprises a suitable material with a cavity formed therein mounted over a body. Elements are formed on the surface of the body and on the top surface of the cavity. In one embodiment, the elements are electrodes of a variable capacitance device, and in another embodiment the elements are partial or total reflectors of incident light from an optical fiber. The surface of the cavity opposite the body is preferably flat and of the order of microns from the body. The device is fabricated by forming a removable layer over a temporary substrate. An appropriate element pattern is formed over the removable layer and the layer is etched in a configuration which will define the cavity. The deformable material is encapsulated over this structure and then removed from the substrate with the element remaining in the cavity. Any removable material remaining in the cavity can then be etched away.Published versio

Variable gap device and method of manufacture

A variable gap device which comprises a suitable material with a cavity formed therein mounted over a body. Elements are formed on the surface of the body and on the top surface of the cavity. In one embodiment, the elements are electrodes of a variable capacitance device, and in another embodiment the elements are partial or total reflectors of incident light from an optical fiber. The surface of the cavity opposite the body is preferably flat and of the order of microns from the body. The device is fabricated by forming a removable layer over a temporary substrate. An appropriate element pattern is formed over the removable layer and the layer is etched in a configuration which will define the cavity. The deformable material is encapsulated over this structure and then removed from the substrate with the element remaining in the cavity. Any removable material remaining in the cavity can then be etched away.Published versio

Genomics of Lynch syndrome and Constitutional mismatch repair deficiency syndrome

Introduction: The mismatch repair system plays an important role in maintaining the genome integrity as it functions to correct mismatches during DNA replication. Heterozygous mutations in one of the mismatch repair (MMR) genes e.g. MLH1, MSH2, MSH6 and PMS2 cause the dominant adult cancer syndrome termed Lynch syndrome (or hereditary non-polyposis colorectal cancer). In our South African cohort, the MLH1 exon 13 c.1528C>T mutation is the most common Lynch syndrome-causing variant in the Mixed Ancestry population. Recently, a patient homozygous for this mutation, diagnosed with Constitutional mismatch repair deficiency (CMMR-D) syndrome was described within this extended cohort. CMMRD syndrome results in an increased predisposition to a range of cancers, most commonly brain and hematological tumours in early childhood. The aims of this thesis were: (i) to determine the rate of extra-colonic cancers in the cohort of Lynch syndrome families in our colorectal cancer registry, (ii) to determine if MLH1 c.1528C>T is a founder mutation, and (iii) to focus on the CMMR-D syndrome as a branch of Lynch syndrome and to potentially use the hypermutability-status in CMMR-D to understand the diverse carcinogenesis in Lynch syndrome. Methods: The registry consisting of Lynch syndrome families was interrogated and analysed to address the aim (i). Haplotype analysis was performed using microsatellite markers around the MHL1 c.1528C>T mutation to determine founder effect for aim (ii). For aim (iii) whole exome sequencing was also performed in a Lynch/ CMMR-D syndrome family in order to investigate the extent of hypermutability in CMMR-D syndrome, and to develop a working hypothesis for carcinogenesis in CMMR-D and Lynch syndromes. Results: From the analysis of the registry it was noted that 396 individuals carried a disease-causing mutation in either MLH1 or MSH2; females have a relatively later age of onset (for cancer) than males and MLH1 mutation carriers develop cancers relatively earlier in life than in individuals with MSH2 mutations. The most common extra-colonic cancers were endometrial and breast in females; in males small bowel cancer was most common, after CRC. The cohort study revealed a large founder effect with the MLH1 c.1528C>T mutation, with the most common inferred (disease-associated) haplotype found in 25 of the 30 subjects tested; the disease-associated haplotype was not present in controls. The mutation aging analysis traced the mutation to be ~225 years old. The WES investigation of the nuclear family within which the CMMR-D patient, including acquired and germline mutations in tissues from the child with CMMR-D, revealed a range of pathways including the extracellular matrix, WNT signaling, TGFβ and p53 as acquiring significant numbers of variants as a result of the MMR deficiency. Discussion and Conclusion: The results which are indicative of the need to improve the Lynch syndrome mutation testing and management for all patients, also suggests the need to develop surveillance programs for extra-colonic cancers, which will improve compliance and disease-free survival. WES investigation of the nuclear family containing a child with CMMR-D point to the potential involvement of a range of pathways associated with cancer development which may be indirectly invoked in the process of tumorigenesis by the wide range of variants acquired as a result of mismatch repair deficiency. It is likely that some of these processes are also involved in the emergence of extracolonic cancers in individuals affected with Lynch syndrome (i.e. heterozygous for mutations in MMR genes)

The lived experiences of burn survivors' adaptation post hospital discharge

With the decrease in burn mortality following improved burn care facilities and methods, burn survivors are often left with residual physical and psychosocial consequences that they have to cope with requiring adaptation and modification of lifestyle. Burn survivors habitually receive excellent treatment for their wounds while in hospital but may experience challenges due to disruption of care and rehabilitation after discharge. This aim of the study was to explore and describe the lived experiences of burn survivors’ adaptation post hospital discharge. A qualitative, hermeneutic, phenomenological design using an interpretive framework was used. A purposeful sampling was used in the selection of nine participants who were above 18 years and had been admitted to the Limpopo Burn Unit while still undergoing reviews at the Plastic and Reconstructive Surgery Clinic. Data were collected through face-to-face interviews using unstructured open-ended questions. Data were analysed using the Colaizzi’s strategy. Three main themes emerged from the data, along with sub-themes. (a)The burn survival experience involved the person in totality with reference to their internal and external environment. (b)The process of recovery was lengthy and started in hospital and continued post discharge at home. (c) Reclaiming their life and finding new meaning was a process of adaptation. The core of the participants’ needs included the need for the care and rehabilitation of the whole person in terms of their physical and psychosocial aspects, the importance of the survivor’s involvement in his/her care, and the rehabilitation. Health care personnel and family support during this difficult time should be available in order to enable the survivors to cope and adapt effectively and reclaim their lives.Health StudiesM.A. (Nursing Science

Blackhood as a category in contemporary discourses on Black Studies: An existentialist philosophical defence

Background: An era and academic milieu that clamour at post-racialist and globalist theoretical frameworks juxtaposed with evidence of growing anti-black dehumanizing racism, and the persistence of psycho-social alienation of black learners in multi-racial educational institutions. Aim: To engage in a critical philosophical–phenomenological and political review of the experience of being-black-in-the-world as a factor that justifies the establishment and maintenance of Black Studies programmes. The article seeks to contribute to the debate on the vagaries accompanying the institutionalisation of culturo-epistemic exclusive spaces for socially suppressed selfhoods in a postmodern academy. Setting: Racialised social environments as affecting Higher Education, with post-apartheid South Africa as a case. Methods: Existential Philosophy, Black Consciousness and Paulo Freire’s philosophy of education. Results: The category of blackness as derived from a Fanonian existential phenomenology and Steve Biko’s perspective, contrasted against Achille Mbembe’s semiological–hermeneutic and cosmopolitan treatment of blackness, is an existential–ontological reality that should function as a cardinal category in educational planning, justifying specialised learning and knowledge-exchange spaces for the re-humanisation of black existence. Conclusion: The experience of black existential reality, conceived from blackhood as an external recognition and an internally self-negotiated consciousness within the social immanence of whiteness, justifies the institutionalisation of learning spaces and programmes that are aimed at nurturing antiracist black self-realisation, namely Black Studies

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation

Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration