Nonignorable data in IRT models: Polytomous responses and response propensity models with covariates

Missing data usually present special problems for statistical analyses, especially when the data are not missing at random, that is, when the ignorability principle defined by Rubin (1976) does not hold. Recently, a substantial number of articles have been published on model-based procedures to handle nonignorable missing data due to item nonresponse (Holman & Glas, 2005; Glas & Pimentel, 2008; Rose, von Davier & Xu, 2010; Pohl, Grӓfe & Rose, 2014). In this approach, an item response theory (IRT) model for the observed data is estimated concurrently with an IRT model for the propensity of the missing data. The present article elaborates on this approach in two directions. Firstly, the preceding articles only consider dichotomously scored items; in the present article it is shown that the approach equally works for polytomously scored items. Secondly, it is shown that the methods can be generalized to allow for covariates in the model for the missing data. Simulation studies are presented to illustrate the efficiency of the proposed methods

Applying prosodic speech features in mental health care: An exploratory study in a life-review intervention for depression

The present study aims to investigate the application of prosodic speech features in a psychological intervention based on lifereview. Several studies have shown that speech features can be used as indicators of depression severity, but these studies are mainly based on controlled speech recording tasks instead of natural conversations. The present exploratory study investigated speech features as indicators of depression in conversations of a therapeutic intervention. The changes in the prosodic speech features pitch, duration of pauses, and total duration of the participant's speaking time were studied over four sessions of a life-review intervention for three older participants. The ecological validity of the dynamics observed for prosodic speech features could not be established in the present study. The changes in speech features differed from what can be expected in an intervention that is effective in decreasing depression and were inconsistent with each other for each of the participants. We suggest future research to investigate changes within the intervention sessions, to relate the changes in feature values to the topical content of the speech, and to relate the speech features directly to depression scores

Conceptualizations of Mental Health Across Europe: Comparing Psychology with Science and Engineering Students

There is a lack of consensus on the conceptualization of mental health, with models emphasizing negative aspects, positive aspects, or both. The models are mainly theory-based and may not fit in with the population’s opinions. The aim of this ongoing study is to investigate the conceptualizations of mental health in Europe from psychology, science, and engineering students’ perspectives in an explorative way through semi-structured interviews. Their conceptualizations of mental health are investigated qualitatively by thematic analysis to compare seven European countries. Results can be used to improve mental health questionnaires and interventions across Europe by enhancing the fit with students’ conceptualization

Maternal diabetes causes developmental delay and death in early-somite mouse embryos

Maternal diabetes causes congenital malformations and delays embryonic growth in the offspring. We investigated effects of maternal diabetes on mouse embryos during gastrulation and early organogenesis (ED7.5-11.5). Female mice were made diabetic with streptozotocin, treated with controlled-release insulin implants, and mated. Maternal blood glucose concentrations increased up to embryonic day (ED) 8.5. Maternal hyperglycemia induced severe growth retardation (approx.1 day) in 53% of the embryos on ED8.5, death in most of these embryos on ED9.5, and the termination of pregnancy on ED10.5 in litters with >20% dead embryos. Due to this selection, developmental delays and reduction in litter size were no longer observed thereafter in diabetic pregnancies. Male and female embryos were equally sensitive. High-throughput mRNA sequencing and pathway analysis of differentially expressed genes showed that retarded embryos failed to mount the adaptive suppression of gene expression that characterized non-retarded embryos (cell proliferation, cytoskeletal remodeling, oxidative phosphorylation). We conclude that failure of perigastrulation embryos of diabetic mothers to grow and survive is associated with their failure to shut down pathways that are strongly down-regulated in otherwise similar non-retarded embryos. Embryos that survive the early and generalized adverse effect of maternal diabetes, therefore, appear the subset in which malformations become manifest

Flourishing in people with depressive symptomatology increases with Acceptance and Commitment Therapy. Post-hoc analyses of a randomized controlled trial

Mental health is more than the absence of mental illness. Rather, both well-being (positive mental health) and mental illness are actually two related continua, with higher levels of well-being defined as “flourishing.” This two-continua model and existing studies about the impact of flourishing on psychopathology underscore the need for interventions that enhance flourishing and well-being. Acceptance and Commitment Therapy (ACT) is a model of cognitive behavioral therapy that aims not only to reduce psychopathology but also to promote flourishing as well. This is the first study to evaluate the impact of ACT on flourishing. A post-analysis was conducted on an earlier randomized controlled trial of a sample of adults with depressive symptomatology who participated in a guided self-help ACT intervention. This post-analysis showed a 5%–28% increase of flourishing by the participants. In addition, the effects on flourishing were maintained at the three-month follow-up. When compared to participants in a control group, the flourishing of the ACT-trained participants increased from 5% to about 14% after nine weeks. In addition to levels of positive mental health at baseline, an increase of psychological flexibility during the intervention was a significant predictor of flourishing at the three-month follow-up

POSITIVE CLINICAL INTERVENTIONS: WHY ARE THEY IMPORTANT AND HOW DO THEY WORK?

In this paper we discuss positive clinical psychology as an emerging field within clinical psychology. Positive clinical psychology is based on research demonstrating that mental health is more than the absence of mental illness, on research showing that wellbeing has buffering effects on the incidence of psychopathology and mental illnesses and on studies demonstrating that positive characteristics, such as positive emotions and gratitude, can predict pathology beyond the predictive power of negative characteristics. In this paper we present three distinct forms of well-being: emotional, psychological and social. In addition we review three types of positive clinical interventions: well-being therapy, positive psychotherapy and acceptance and commitment therapy. The paper ends with a call for a transformation of mental health care in which illness oriented treatments are complemented with well-being oriented treatments