Effect of habituation on the susceptibility of the rat to restraint ulcers

The frequency and gravity of restraint ulcers were found to significantly diminish in rats previously exposed to brief periods of immobilization. The rats' becoming habituated to restraint conditions probably explains this phenomenon

Freund-Rubin Revisited

We utilise the duality between M theory and Type IIA string theory to show the existence of Freund-Rubin compactifications of M theory on 7-manifolds with singularities supporting chiral fermions. This leads to a concrete way to study phenomenologically interesting quantum gravity vacua using a holographically dual three dimensional field theory.Comment: reference adde

Noncommutative Riemannian Geometry of the Alternating Group A_4

We study the noncommutative Riemannian geometry of the alternating group A_4=(Z_2 \times Z_2)\cross Z_3 using a recent formulation for finite groups. We find a unique `Levi-Civita' connection for the invariant metric, and find that it has Ricci-flat but nonzero Riemann curvature. We show that it is the unique Ricci-flat connection on $A_4$ with the standard framing (we solve the vacuum Einstein's equation). We also propose a natural Dirac operator for the associated spin connection and solve the Dirac equation. Some of our results hold for any finite group equipped with a cyclic conjugacy class of 4 elements. In this case the exterior algebra $\Omega(A_4)$ has dimensions $1:4:8:11:12:12:11:8:4:1$ with top-form 9-dimensional. We also find the noncommutative cohomology $H^1(A_4)=C$.Comment: 28 pages Latex no figure

Suppression of Giant Magnetoresistance by a superconducting contact

We predict that current perpendicular to the plane (CPP) giant magnetoresistance (GMR) in a phase-coherent magnetic multilayer is suppressed when one of the contacts is superconducting. This is a consequence of a superconductivity-induced magneto-resistive (SMR) effect, whereby the conductance of the ferromagnetically aligned state is drastically reduced by superconductivity. To demonstrate this effect, we compute the GMR ratio of clean (Cu/Co)_nCu and (Cu/Co)_nPb multilayers, described by an ab-initio spd tight binding Hamiltonian. By analyzing a simpler model with two orbitals per site, we also show that the suppression survives in the presence of elastic scattering by impurities.Comment: 5 pages, 4 figures. Submitted to PR

High Dimensional Classification with combined Adaptive Sparse PLS and Logistic Regression

Motivation: The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent over-optimistic predictions. This challenge can be tackled by compression and variable selection, which combined constitute a powerful framework for classification, as well as data visualization and interpretation. However, current proposed combinations lead to instable and non convergent methods due to inappropriate computational frameworks. We hereby propose a stable and convergent approach for classification in high dimensional based on sparse Partial Least Squares (sparse PLS). Results: We start by proposing a new solution for the sparse PLS problem that is based on proximal operators for the case of univariate responses. Then we develop an adaptive version of the sparse PLS for classification, which combines iterative optimization of logistic regression and sparse PLS to ensure convergence and stability. Our results are confirmed on synthetic and experimental data. In particular we show how crucial convergence and stability can be when cross-validation is involved for calibration purposes. Using gene expression data we explore the prediction of breast cancer relapse. We also propose a multicategorial version of our method on the prediction of cell-types based on single-cell expression data. Availability: Our approach is implemented in the plsgenomics R-package.Comment: 9 pages, 3 figures, 4 tables + Supplementary Materials 8 pages, 3 figures, 10 table

Back At Dear Old Home Sweet Home

https://digitalcommons.library.umaine.edu/mmb-vp/1066/thumbnail.jp