Semi-quantitative indices of 2-[18F]FDG PET/CT in assessing cardiovascular and non-cardiovascular manifestations of IgG4-related disease and treatment response

IgG4-related disease (IgG4-RD) is a heterogeneous autoimmune disorder characterised by inflammatory lesions. Diagnostic imaging, such as 2-[18F]FDG PET/CT, is critical in evaluation of the disease, especially for potentially lethal cardiovascular manifestations. This retrospective study examines the usefulness of semi-quantitative parameters of 2-[18F]FDG PET/CT in monitoring IgG4-RD in patients with and without cardiovascular manifestations.Published versionWe would like to acknowledge the SingHealth Medical Students Talent Development Award for funding this publication

Role of nuclear medicine imaging in evaluation of complications following renal transplant

Evaluation of a failing renal allograft is a complex and challenging diagnostic problem. While ultrasonography with colour Doppler is usually the first approach for evaluation of graft dysfunction, radionuclide imaging is an excellent modality which provides complementary information regarding the perfusion and function of the allograft without any deleterious effect on the precious allograft. In this article, we review the imaging techniques of the nuclear medicine studies most commonly performed after renal transplant, discuss their roles and limitations in different clinical settings and illustrate with cases from our institution. Lastly, we will explore future development in the arena of nuclear imaging for renal transplant related complications

Facing a disruptive threat: how can a nuclear medicine service be prepared for the coronavirus outbreak 2020?

10.1007/s00259-020-04790-2EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING4771645-164

Radiolabeled Liposomes for Nuclear Imaging Probes

Quantitative nuclear imaging techniques are in high demand for various disease diagnostics and cancer theranostics. The non-invasive imaging modality requires radiotracing through the radioactive decay emission of the radionuclide. Current preclinical and clinical radiotracers, so-called nuclear imaging probes, are radioisotope-labeled small molecules. Liposomal radiotracers have been rapidly developing as novel nuclear imaging probes. The physicochemical properties and structural characteristics of liposomes have been elucidated to address their long circulation and stability as radiopharmaceuticals. Various radiolabeling methods for synthesizing radionuclides onto liposomes and synthesis strategies have been summarized to render them biocompatible and enable specific targeting. Through a variety of radionuclide labeling methods, radiolabeled liposomes for use as nuclear imaging probes can be obtained for in vivo biodistribution and specific targeting studies. The advantages of radiolabeled liposomes including their use as potential clinical nuclear imaging probes have been highlighted. This review is a comprehensive overview of all recently published liposomal SPECT and PET imaging probes

F-18-FDG PET/CT Manifestations of IgG4-related Disease

10.1259/bjr.20210105BRITISH JOURNAL OF RADIOLOGY94112

Current Status and Growth of Nuclear Theranostics in Singapore

10.1007/s13139-019-00580-3NUCLEAR MEDICINE AND MOLECULAR IMAGING53296-10