A perspective on the widening gap between Covishield vaccine doses in India

The Oxford University-AstraZeneca’s vector-based vaccine called Covishield (ChAdOx1 nCoV- 19 Vaccine) is being manufactured and distributed by Serum Institute of India (SII).  National roll out of this vaccine was in a phased manner starting from 16th January 2021. At present, many states are facing shortage of vaccines. Government of India kept changing its policy on dosing gap of Covishield vaccine based on researches. The latest recommendation citing “real-life evidence” from the UK is to extend the two doses of Covishield to 12-16 weeks. This reasonable approach will not only a breathing space for the government but also aids in free up doses for a larger number of people to get their first dose of the vaccine

COSMECEUTICALSâ€: AN OPINION IN THE DIRECTION OF PHARMACEUTICALS

 Cosmeceuticals are the latest addition to the health industry and are described as cosmetic products with drug-like activities. Cosmetics are productsthat are used to cleanse and beautify the skin (Millikan, 2001). Pharmaceuticals are essentially drug products and are defined as products that prevent,mitigate, treat or cure disease and/or affect the structure or function of the body (Vermeer and Gilchrest, 1996). Cosmeceuticals is a deliberateportmanteau of these two terms and is intended to connote drug-like benefits from an otherwise cosmetic product. While the food, drug, and cosmeticact does not recognize the term cosmeceutical,†the cosmetic industry has begun to use this word to refer to cosmetic products that have drug-likebenefits. The term cosmeceutical was coined by Kilgman, but these lines of product became popular in 1996 and have an expanding market that hasrapidly reached Africa. Many scientists and health consumers in Africa may not be conversant with this line of products. They may, therefore, be underresearchedor over-utilized. In the cosmetic arena, many materials are used commercially. Cosmetic ingredients previously considered inert†havethe potential to provide a biologic effect to the skin. In a cosmeceutical formulation, the boundary between an active†and inert†ingredient may beobscured. There is most common names of the different ingredients used in cosmeceutical products such as antioxidants, the binding agent, emollients,emulsions, humectants, lubricants, preservatives, solvents, surfactants, vehicle, etc. Potential for cosmeceutical ingredients in the United States aloneis SI00 million and includes such products as skin peelers, wrinkle creams, emollients, hair growth stimulants, skin lighteners and darkeners, andbotanicals. The 75 million baby boomers are the major market for cosmeceuticals. Cosmeceuticals claims are largely unsubstantiated and the term,though misleading, has probably come to stay. The term and the target consumers appear flamboyant enough to with stand Government regulations.In a free trade world, the benefits and adverse effects of cosmeceuticals are probably optimized by frequent review to inform the clinical and publicstake-holders of their uses and limitations. This comprehensive review attempts to briefly, expand the recent knowledge about cosmeceuticals.Keywords: Cosmetics, Formulation/stability, Safety testing, Claim substantiation

Ball proximinality of equable spaces

The notion of ball proximinality and the strong ball proximinality were recently introduced in [2]. We prove that an equable subspace $Y$ of a Banach space $X$ is strongly ball proximinal and the metric projection from $X$, onto the closed unit ball of $Y$, is Hausdorff metric continuous

Ball Proximinality of Closed * Subalgebras in C(Q)

The notion of ball proximinality and the strong ball proximinality were recently introduced in [2]. We prove that a closed * subalgebra of () is strongly ball proximinal in () and the metric projection from (), onto the closed unit ball of , is Hausdorff® metric continuous and hence has continuous selection.The authors is partially supported by DST/INT/US(NSF-RPO-0141)2003 and by NSF-0ISE-0352523.peerReviewe

Chebyshev centers and some geometric properties of Banach spaces

In this paper, we study two properties (P1)(P1) and (P2)(P2) introduced in the literature for studying the existence and stability of relative Chebyshev centers. We reformulate these properties in a way that leads naturally to our results. We mainly relate these properties with some geometric properties of Banach spaces. In particular, reflexive spaces having the Kadec-Klee property are characterized in terms of property (P1)(P1) and uniform convexity is characterized in terms of property (P2)(P2). Some continuity results for the center map are also presented