Preparation and characterization of hydralazine mouth dissolving tablet by using super-disintegrates

Tablet dosage form is the most popular among all existing conventional dosage forms because of its convenience of self-administration, compactness and easy manufacturing. Many patients find it difficult to swallow tablets and capsules. The difficulty is experienced in particular by pediatric and geriatric patients, but it also applies to people who are ill on bed and to those active working patients who are busy or traveling, especially those who have no access to water. Mouth dissolving tablet was prepared by addition of superdisintegrants (Ac-Di-Sol, Sodium starch glycolate and Crospovidone). The tablets were evaluated for their organoleptic (Color, Odor, Taste), physical (Size, Shape and Texture) and quality control parameters (Diameter, Thickness, Hardness, Friability, Disintegration Time and Wetting Time). Hence, mouth dissolving tablets of resinate can be successfully prepared by superdisintegrants, maintaining their disintegration time less than 1 minute, which provide faster effect and better patient compliance. These tablets may be helpful for geriatric and pediatric patients experience difficulty in swallowing conventional tablets, which leads to poor patient compliance. Thus, it was concluded that the method designed for drug resinate complexation and tablet formulation is simple, rapid, cost effective and highly efficient

Formulation and evaluation of fast dissolving oral wafers of linagliptin

Wafers are modern oral dosage forms which are commonly used by patients worldwide. Also, in acute pain, these dosage types can be used to get immediate relief.  These oral sublingual wafers are nothing more than a thin oral stripe which dissolves immediately due to the presence of saliva in the mouth when placed in the sublingual cavity by releasing medication within a short span of time. The faster dissolution can be achieved by using different superdisintegrants in different concentrations and a comparative study of different superdisintegrants has been carried out. Present investigation aims to formulate fast dissolving wafer of linagliptin using different film forming agents. From the latest research it can be inferred that fast-dissolving oral films of drug release are preferable. The films prepared by HPMC K4 and K15 and CCS and CP had shown strong mechanical power, release of narcotics, period for disintegration and analysis of dissolution. F7 formulation is considered the better with less disintegrating time and release in 10 min according to the results obtained. Percent drug release and disintegration time was taken as responses for study which were found within the accepted ranges