Prediction of Mechanical Response of Nickel based Superalloy Subjected to Creep Fatigue Interaction Loading using Unified Mechanics Theory

In order to simulate and predict material's real-time responses for a component under complex mechanical and thermal loads, continuum damage mechanics (CDM) is employed. However, majority of the models found in the literature are phenomenological and primarily based on curve fitting, which offer limited understanding of the underlying physics of the problem. A few physics-based models have been developed that provide greater insights. Unified mechanics theory (UMT) is one such approach that captures entropy generation due to various dissipative mechanism which aims to explain the physics of the problem. During hold time in strain-controlled creep-fatigue interaction loading, stress relaxation is observed. This study attempts to capture stress relaxation response due to creep-fatigue interaction of nickel-based superalloys using UMT, which is regarded as a more scientific method than simply fitting curves. The evolution of creep strain energy with hold time is used to understand how material ages over time due to stress relaxation during creep-fatigue interaction loading

A Unified Mechanics Theory based Damage Model for Creep in Nickel based Superalloys

Unified Mechanics Theory’s (UMT) entropy-based damage parameter, also known as the “Thermodynamic State Index” has been proven to be consistent and useful in predicting the fatigue life of different metal alloys. In recent times, studies have also demonstrated its applicability towards creep damage in nickel-based superalloys under a limited set of conditions. However, the usefulness of the “Thermodynamic State Index” in estimating damage at different temperatures, and creep loads for different metal alloys has not been evaluated yet. In this paper, creep in INCONEL 600 alloy is modeled using Norton’s creep law modified with entropy-based damage (Thermodynamic State Index). The model is calibrated to predict both damage and creep strains for any given input of stress, temperature, and time. The available database on INCONEL 600 is used in parts to both calibrate and validate the prescribed model. The damage evolution for different cases is compared and imminent conclusions are drawn

A prospective, open label, randomized-controlled study to evaluate the efficacy and safety of MyVir tablets in mildly symptomatic COVID-19 patients

Background: Coronavirus can cause pneumonia, respiratory failure and death. The emergence of novel coronavirus has posed a challenging situation that warrants urgent global attention. Currently there was no effective therapy available for COVID-19 and hence antiviral and immune modulators are most sought after medicines to manage complications of COVID-19.Methods: In this study involving mild COVID-19 we randomized 42 patients to receive a MyVir tablets twice daily along with standard of care (SOC) or SOC alone in 1:1 ratio for 14 days. We evaluated the benefits of MyVir tablets by assessing clinical outcomes and improvement in immune markers (LDH, CRP, D-dimer, TLC).Results: At the end of the study the immune markers in MyVir group improved significantly compared to control group. In patients who received MyVir, CRP decreased from 3.3 mg/l to 1.7 mg/l (p=0.0171). D-dimer decreased from 0.589 on day 0 to 0.368 on day 14 (p=0.03) and LDH decreased from 224 U/l on day 0 to 158 U/l on day 14 in test group (p=0.05). TLC showed favorable improvement in study group compared to control group. Early recovery from COVID-19 symptoms was observed in patients on MyVir treated group. Patients treated with MyVir tablets reduced the duration of hospitalization when given along with standard of care.Conclusions: MyVir accelerated recovery of COVID-19 patients by early improvement in clinical symptoms and immune markers in this study and results clearly indicates that MyVir tablets has antiviral, immune booster activity. Hence this study provides evidence that MyVir has definitive role in the management of mild COVID-19 patients along with standard of care (funded by Mi Lab Life Sciences(P) Ltd. CTRI no. CTRI/2020/05/024967)

4-Hydr­oxy-3-[(2E)-3-(3,4,5-trimethoxy­phen­yl)prop-2-eno­yl]-2H-chromen-2-one

A new chalcone of the coumarin, C21H18O7, containing an annulated α-pyrone ring, was obtained by condensation of the borate complex of ac­yl(hydr­oxy)coumarin with trimethoxy­benzaldehyde. The structure exhibits intra­molecular hydrogen bonding between the hydroxyl oxygen and the ketonic oxygen in the coumarin group. The bicyclic coumarin fragment and the benzene ring form a dihedral angle of 17.1 (4)°. The crystal packing involves dimers inter­connected by C—H⋯O hydrogen bonding

Resourcefulness of cone beam computed sialography in detection of multiple radiolucent sialoliths: A case report

Obstructive conditions of the salivary glands are common and may necessitate imaging of the gland for the purpose of diagnosis and management. Sialography is considered the gold standard for examining obstructive conditions of the parotid and submandibular glands but is largely influenced by the imaging technique to which it is coupled. The aim of this paper is to discuss the importance of cone beam computed sialography imaging which is a relatively new and very promising imaging modality in the detection of radiolucent sialoliths and to report a case of detection of radiolucent parotid sialoliths using cone beam computed sialography