Impact of Oral Meloxicam on Circulating Physiological Biomarkers of Stress and Inflammation in Beef Steers After Long Distance Transportation

We hypothesized that meloxicam administration to beef steers before shipping may be effective at reducing the impact of transportation on stress biomarkers. Circulating physiological biomarkers of stress were analyzed in a transportation trial between a meloxicam treatment group and a placebo treatment group. There were significant differences in stress biomarkers between treatment groups following transport. This suggests that there may be practical benefits for the use of long-acting non-steroidal anti-inflammatory drugs (NSAIDs), specifically meloxicam, to mitigate the negative effect of transport on cattle physiology

Associations of various physical and blood analysis variables with experimentally induced Mycoplasma bovis pneumonia in calves

Objective-To determine associations of blood analysis variables and orbit and nasal planum surface temperatures with the onset and severity of Mycoplasma bovis pneumonia in calve

Assessment of a commercially available point-of-care assay for the measurement of bovine cardiac troponin I concentration

Objective-To assess a commercially available point-of-care assay for measurement of bovine cardiac troponin I (cTnI) concentration in blood and plasma sample

Serum Concentrations of Haptoglobin and Haptoglobin-Matrix Metalloproteinase 9 (Hp-MMP 9) Complexes of Bovine Calves in a Bacterial Respiratory Challenge Model

Serum haptoglobin (Hp) and haptoglobin matrix metalloproteinase 9 complexes (Hp-MMP 9) have been identified as biomarkers with diagnostic potential in cattle with conditions resulting in an acute inflammatory response. The purpose of this study was to evaluate potential diagnostic applications of serum Hp and Hp-MMP 9 concentrations in calves with BRD and establish a timeline for their detection in calves experimentally challenged with Bibersteinia trehalosi and Mannheimia haemolytica. Thirty-five cross bred dairy calves were inoculated via tracheal catheterization with either a PCR confirmed leukotoxin negative B. trehalosi isolate, a PCR confirmed leukotoxin positive B. trehalosi isolate, a Mannheimia haemolyticaisolate, a combination of leukotoxin negative B. trehalosi and M. haemolytica, or a negative control. Serum samples were collected throughout the study. Calves were euthanized and necropsy performed on day 10 post inoculation. M. haemolytica inoculated calves had increased lung involvement. Serum Hp and Hp- MMP 9 concentrations were elevated compared to the other treatment groups. Increases in serum Hp and Hp-MMP 9 concentrations for the M. haemolyticagroup were significantly different from other study groups on day 7 of the study. B. trehalosi inoculated calves did not have increased lung involvement compared to control calves, but the leukotoxin positive B. trehalosi group demonstrated increased serum Hp-MMP 9 concentrations from day 3 to the end of the study compared to the pre-inoculation concentrations. Serum Hp-MMP 9 concentration is a useful diagnostic tool for detecting early pulmonary inflammation in calves challenged with B. trehalosi and M. haemolytica. Serum Hp-MMP 9 may also be a useful tool in detecting subclinical pulmonary inflammation in challenged calves.This article is from BMC Veterinary Research 10 (2014): 285, doi:10.1186/s12917-014-0285-5. Posted with permission.</p

Serum concentrations of haptoglobin and haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complexes of bovine calves in a bacterial respiratory challenge model

Serum haptoglobin (Hp) and haptoglobin matrix metalloproteinase 9 complexes (Hp-MMP 9) have been identified as biomarkers with diagnostic potential in cattle with conditions resulting in an acute inflammatory response. The purpose of this study was to evaluate potential diagnostic applications of serum Hp and Hp-MMP 9 concentrations in calves with BRD and establish a timeline for their detection in calves experimentally challenged with Bibersteinia trehalosi and Mannheimia haemolytica. Thirty-five cross bred dairy calves were inoculated via tracheal catheterization with either a PCR confirmed leukotoxin negative B. trehalosi isolate, a PCR confirmed leukotoxin positive B. trehalosi isolate, a Mannheimia haemolyticaisolate, a combination of leukotoxin negative B. trehalosi and M. haemolytica, or a negative control. Serum samples were collected throughout the study. Calves were euthanized and necropsy performed on day 10 post inoculation. M. haemolytica inoculated calves had increased lung involvement. Serum Hp and Hp- MMP 9 concentrations were elevated compared to the other treatment groups. Increases in serum Hp and Hp-MMP 9 concentrations for the M. haemolyticagroup were significantly different from other study groups on day 7 of the study. B. trehalosi inoculated calves did not have increased lung involvement compared to control calves, but the leukotoxin positive B. trehalosi group demonstrated increased serum Hp-MMP 9 concentrations from day 3 to the end of the study compared to the pre-inoculation concentrations. Serum Hp-MMP 9 concentration is a useful diagnostic tool for detecting early pulmonary inflammation in calves challenged with B. trehalosi and M. haemolytica. Serum Hp-MMP 9 may also be a useful tool in detecting subclinical pulmonary inflammation in challenged calves

Impact of Oral Meloxicam on Circulating Physiological Biomarkers of Stress and Inflammation in Beef Steers After Long Distance Transportation

We hypothesized that meloxicam administration to beef steers before shipping may be effective at reducing the impact of transportation on stress biomarkers. Circulating physiological biomarkers of stress were analyzed in a transportation trial between a meloxicam treatment group and a placebo treatment group. There were significant differences in stress biomarkers between treatment groups following transport. This suggests that there may be practical benefits for the use of long-acting non-steroidal anti-inflammatory drugs (NSAIDs), specifically meloxicam, to mitigate the negative effect of transport on cattle physiology.</p