157 research outputs found
Expansion of Vortex Cores by Strong Electronic Correlation in LaSrCuO at Low Magnetic Induction
The vortex core radius \rv, defined as the peak position of the supercurrent
around the vortex, has been determined by muon spin rotation measurements in
the mixed state of \lscox for , 0.15, and 0.19. At lower doping (x=0.13
and 0.15), \rv(T) increases with decreasing temperature T, which is opposite to
the behavior predicted by the conventional theory. Moreover, \rv(T\to0) is
significantly larger than the Ginsburg-Landau coherence length determined by
the upper critical field, and shows a clear tendency to decrease with
increasing the doping x. These features can be qualitatively reproduced in a
microscopic model involving antiferromagnetic electronic correlations.Comment: 6 pages, 4 figures, to be published in Phys. Rev.
Gravitational Collapse: Expanding and Collapsing Regions
We investigate the expanding and collapsing regions by taking two well-known
spherically symmetric spacetimes. For this purpose, the general formalism is
developed by using Israel junction conditions for arbitrary spacetimes. This
has been used to obtain the surface energy density and the tangential pressure.
The minimal pressure provides the gateway to explore the expanding and
collapsing regions. We take Minkowski and Kantowski-Sachs spacetimes and use
the general formulation to investigate the expanding and collapsing regions of
the shell.Comment: 12 pages, 4 figures, accepted for publication in Gen. Relativ. Gra
Gravitational Charged Perfect Fluid Collapse in Friedmann Universe Models
This paper is devoted to study the gravitational charged perfect fluid
collapse in the Friedmann universe models with cosmological constant. For this
purpose, we assume that the electromagnetic field is so weak that it does not
introduce any distortion into the geometry of the spacetime. The results
obtained from the junction conditions between the Friedmann and the
Reissner-Nordstrm de-Sitter spacetimes are used to solve the field
equations. Further, the singularity structure and mass effects of the
collapsing system on time difference between the formation of apparent horizons
and singularity have been studied. This analysis provides the validity of
Cosmic Censorship Hypothesis. It is found that the electric field affects the
area of apparent horizons and their time of formation.Comment: 17 pages, accepted for publication in Astrophys. Space Sc
Junction Conditions and Consequences of Quasi-Spherical Space-Time with Electro-Magnetic Field and Vaidya Matric
In this work the junction conditions between the exterior
Reissner-Nordstrom-Vaidya space-time with the interior quasi-spherical Szekeres
space-time have been studied for analyzing gravitational collapse in the
presence of a magneto-hydrodynamic fluid undergoing dissipation in the form of
heat flow. We have discussed about the apparent horizon and have evaluated the
time difference between the formation of apparent horizon and central
singularity.Comment: 8 latex pages, RevTex style, no figure
Fluorescent carbon dioxide indicators
Over the last decade, fluorescence has become the dominant tool in biotechnology and medical imaging. These exciting advances have been underpinned by the advances in time-resolved techniques and instrumentation, probe design, chemical / biochemical sensing, coupled with our furthered knowledge in biology. Complementary volumes 9 and 10, Advanced Concepts of Fluorescence Sensing: Small Molecule Sensing and Advanced Concepts of Fluorescence Sensing: Macromolecular Sensing, aim to summarize the current state of the art in fluorescent sensing. For this reason, Drs. Geddes and Lakowicz have invited chapters, encompassing a broad range of fluorescence sensing techniques. Some chapters deal with small molecule sensors, such as for anions, cations, and CO2, while others summarize recent advances in protein-based and macromolecular sensors. The Editors have, however, not included DNA or RNA based sensing in this volume, as this were reviewed in Volume 7 and is to be the subject of a more detailed volume in the near future
Identification of the bulk pairing symmetry in high-temperature superconductors: Evidence for an extended s-wave with eight line nodes
we identify the intrinsic bulk pairing symmetry for both electron and
hole-doped cuprates from the existing bulk- and nearly bulk-sensitive
experimental results such as magnetic penetration depth, Raman scattering,
single-particle tunneling, Andreev reflection, nonlinear Meissner effect,
neutron scattering, thermal conductivity, specific heat, and angle-resolved
photoemission spectroscopy. These experiments consistently show that the
dominant bulk pairing symmetry in hole-doped cuprates is of extended s-wave
with eight line nodes, and of anisotropic s-wave in electron-doped cuprates.
The proposed pairing symmetries do not contradict some surface- and
phase-sensitive experiments which show a predominant d-wave pairing symmetry at
the degraded surfaces. We also quantitatively explain the phase-sensitive
experiments along the c-axis for both Bi_{2}Sr_{2}CaCu_{2}O_{8+y} and
YBa_{2}Cu_{3}O_{7-y}.Comment: 11 pages, 9 figure
Dispersion of Ordered Stripe Phases in the Cuprates
A phase separation model is presented for the stripe phase of the cuprates,
which allows the doping dependence of the photoemission spectra to be
calculated. The idealized limit of a well-ordered array of magnetic and charged
stripes is analyzed, including effects of long-range Coulomb repulsion.
Remarkably, down to the limit of two-cell wide stripes, the dispersion can be
interpreted as essentially a superposition of the two end-phase dispersions,
with superposed minigaps associated with the lattice periodicity. The largest
minigap falls near the Fermi level; it can be enhanced by proximity to a (bulk)
Van Hove singularity. The calculated spectra are dominated by two features --
this charge stripe minigap plus the magnetic stripe Hubbard gap. There is a
strong correlation between these two features and the experimental
photoemission results of a two-peak dispersion in LaSrCuO, and
the peak-dip-hump spectra in BiSrCaCuO. The
differences are suggestive of the role of increasing stripe fluctuations. The
1/8 anomaly is associated with a quantum critical point, here expressed as a
percolation-like crossover. A model is proposed for the limiting minority
magnetic phase as an isolated two-leg ladder.Comment: 24 pages, 26 PS figure
Low-frequency dilatational wave propagation through unsaturated porous media containing two immiscible fluids
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Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: reanalysis of a randomized controlled trial
Background
Clear recognition of the damaging effects of poverty on early childhood development has fueled an interest in interventions aimed at mitigating these harmful consequences. Psychosocial interventions aimed at alleviating the negative impacts of poverty on children are frequently shown to be of benefit, but effect sizes are typically small to moderate. However, averaging outcomes over an entire sample, as is typically done, could underestimate efficacy because weaker effects on less susceptible individuals would dilute estimation of effects on those more disposed to respond. This study investigates whether a genetic polymorphism of the serotonin transporter gene moderates susceptibility to a psychosocial intervention.
Methods and findings
We reanalyzed data from a randomized controlled trial of a home-visiting program delivered by community health workers in a black, isiXhosa-speaking population in Khayelitsha, South Africa. The intervention, designed to enhance maternal-infant attachment, began in the third trimester and continued until 6 mo postpartum. Implemented between April 1999 and February 2003, the intervention comprised 16 home visits delivered to 220 mother–infant dyads by specially trained community health workers. A control group of 229 mother–infant dyads did not receive the intervention. Security of maternal-infant attachment was the main outcome measured at infant age 18 mo. Compared to controls, infants in the intervention group were significantly more likely to be securely attached to their primary caregiver (odds ratio [OR] = 1.7, p = 0.029, 95% CI [1.06, 2.76], d = 0.29). After the trial, 162 intervention and 172 control group children were reenrolled in a follow-up study at 13 y of age (December 2012–June 2014). At this time, DNA collected from 279 children (134 intervention and 145 control) was genotyped for a common serotonin transporter polymorphism. There were both genetic data and attachment security data for 220 children (110 intervention and 110 control), of whom 40% (44 intervention and 45 control) carried at least one short allele of the serotonin transporter gene. For these 220 individuals, carrying at least one short allele of the serotonin transporter gene was associated with a 26% higher rate of attachment security relative to controls (OR = 3.86, p = 0.008, 95% CI [1.42, 10.51], d = 0.75), whereas there was a negligible (1%) difference in security between intervention and control group individuals carrying only the long allele (OR = 0.95, p = 0.89, 95% CI [0.45, 2.01], d = 0.03). Expressed in terms of absolute risk, for those with the short allele, the probability of secure attachment being observed in the intervention group was 84% (95% CI [73%, 95%]), compared to 58% (95% CI [43%, 72%]) in the control group. For those with two copies of the long allele, 70% (95% CI [59%, 81%]) were secure in the intervention group, compared to 71% (95% CI [60%, 82%]) of infants in the control group. Controlling for sex, maternal genotype, and indices of socioeconomic adversity (housing, employment, education, electricity, water) did not change these results. A limitation of this study is that we were only able to reenroll 49% of the original sample randomized to the intervention and control conditions. Attribution of the primary outcome to causal effects of intervention in the present subsample should therefore be treated with caution.
Conclusions
When infant genotype for serotonin transporter polymorphism was taken into account, the effect size of a maternal-infant attachment intervention targeting impoverished pregnant women increased more than 2.5-fold when only short allele carriers were considered (from d = 0.29 for all individuals irrespective of genotype to d = 0.75) and decreased 10-fold when only those carrying two copies of the long allele were considered (from d = 0.29 for all individuals to d = 0.03). Genetic differential susceptibility means that averaging across all participants is a misleading index of efficacy. The study raises questions about how policy-makers deal with the challenge of balancing equity (equal treatment for all) and efficacy (treating only those whose genes render them likely to benefit) when implementing psychosocial interventions
Investigation of autosomal genetic sex differences in Parkinson's disease
Objective: Parkinson's disease (PD) is a complex neurodegenerative disorder. Men are on average similar to 1.5 times more likely to develop PD compared to women with European ancestry. Over the years, genomewide association studies (GWAS) have identified numerous genetic risk factors for PD, however, it is unclear whether genetics contribute to disease etiology in a sex-specific manner.Methods: In an effort to study sex-specific genetic factors associated with PD, we explored 2 large genetic datasets from the International Parkinson's Disease Genomics Consortium and the UK Biobank consisting of 13,020 male PD cases, 7,936 paternal proxy cases, 89,660 male controls, 7,947 female PD cases, 5,473 maternal proxy cases, and 90,662 female controls. We performed GWAS meta-analyses to identify distinct patterns of genetic risk contributing to disease in male versus female PD cases.Results: In total, 19 genomewide significant regions were identified and no sex-specific effects were observed. A high genetic correlation between the male and female PD GWAS were identified (rg = 0.877) and heritability estimates were identical between male and female PD cases (similar to 20%).Interpretation: We did not detect any significant genetic differences between male or female PD cases. Our study does not support the notion that common genetic variation on the autosomes could explain the difference in prevalence of PD between males and females cases at least when considering the current sample size under study. Further studies are warranted to investigate the genetic architecture of PD explained by X and Y chromosomes and further evaluate environmental effects that could potentially contribute to PD etiology in male versus female patients.Neurological Motor Disorder
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