Rotavirus-associated seizures and reversible corpus callosum lesion

Rotavirus is a non-enveloped double-stranded RNA virus that causes severe gastroenteritis in children, but complications are rarely reported. Some reports have shown that rotavirus can induce diverse complications of the central nervous system, such as seizures, encephalopathy with a reversible splenial lesion, encephalitis, cerebral white matter abnormalities, and cerebellitis. Here, we present a 2-year-old patient with seizures, who had an isolated splenial lesion in the corpus callosum on neuroimaging, and the rotavirus antigen detected in faeces. © Lietuvos mokslu akademija, 2019. Other Abstract: ROTAVIRUSO SUKELTI TRAUKULIAI IR LAIKINAS DIDZIOSIOS SMEGENU JUNGTIES PAZEIDIMAS: SantraukaRotavirusas yra dvigrandes RNR virusas be apvalkalo, sukeliantis sunku vaiku gastroenterita, taciau apie komplikacijas pranesama retai. Kai kurie atveju aprasymai rodo, kad rotavirusas gali sukelti ivairias centrines nervu sistemos komplikacijas, tokias kaip traukuliai, encefalopatija su trumpalaikiu didziosios smegenu jungties pazeidimu, encefalitas, smegenu baltosios medziagos anomalijos ir cerebelitas. Cia pristatome dveju metu pacienta su traukuliais, kuriam laikinas didziosios smegenu jungties pazeidimas buvo nustatytas neurovaizdinimo metu, o rotaviruso antigenas aptiktas ismatose.Raktazodziai: rotavirusas, vaiku traukuliai, rotaviruso komplikacijos.publishersversionPeer reviewe

Health-related quality of life of the parents of children hospitalized due to acute rotavirus infection : A cross-sectional study in Latvia

Funding Information: Financial competing interests: Project was granted by Riga Stradins University (Grant No. RSU ZP 06/2013/2–3/155). Manuscript was drafted as part of a project. Non-financial competing interests: This manuscript is part of the doctoral Thesis of the corresponding author Gunta Laizane. Publisher Copyright: © 2018 The Author(s).Background: Rotavirus is the leading cause of severe diarrhea in young children and infants worldwide, representing a heavy public health burden. Limited information is available regarding the impact of rotavirus gastroenteritis on the quality of life of affected children and their families. The objectives of study were to estimate the impact of rotavirus infection on health-related quality of life (HRQL), to assess the social and emotional effects on the families of affected children. Methods: This study enrolled all (n=527) RotaStrip®-positive (with further PCR detection) cases (0-18 years of age) hospitalized from April 2013 to December 2015 and their caregivers. A questionnaire comprising clinical (filled-in by the medical staff) and social (filled by the caregivers) sections was completed per child. Results: Main indicators of emotional burden reported by caregivers were compassion (reported as severe/very severe by 91.1% of parents), worry (85.2%), stress/anxiety (68.0%). Regarding social burden, 79.3% of caregivers reported the need to introduce changes into their daily routine due to rotavirus infection of their child. Regarding economic burden, 55.1% of parents needed to take days off work because of their child's sickness, and 76.1% of parents reported additional expenditures in the family's budget. Objective measures of their child's health status were not associated with HRQL of the family, as were the parent's subjective evaluation of their child's health and some sociodemographic factors. Parents were significantly more worried if their child was tearful (p=0.006) or irritable (p<0.001). Parents were more stressful/anxious if their child had a fever (p=0.003), was tearful (p<0.001), or was irritable (p<0.001). Changes in parents' daily routines were more often reported if the child had a fever (p=0.02) or insufficient fluid intake (p=0.04). Conclusion: Objective health status of the child did not influence the emotional, social or economic burden, whereas the parents' subjective perception of the child's health status and sociodemographic characteristics, were influential. A better understanding of how acute episodes affect the child and family, will help to ease parental fears and advise parents on the characteristics of rotavirus infection and the optimal care of an infected child.publishersversionPeer reviewe

Clinical characterisation of rota virus infection associated with most commonly circulating genotypes in children hospitalised in children's university hospital : A cross-sectional study in Latvia

In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children's Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.publishersversionPeer reviewe

Clinical Characterisation of Rota Virus Infection Associated with Most Commonly Circulating Genotypes in Children Hospitalised in Children’s University Hospital: A Cross-Sectional Study in Latvia

In developed and developing countries, most cases of acute gastroenteritis in children are caused by viruses, and rotaviruses are known as the leading cause. The aim of our study was to estimate the main circulating serotypes of rotavirus before the introduction of routine immunisation in Latvia, and to search for their possible correlation with clinical symptoms and circulating genotypes. A cross-sectional study was carried out among children who had been hospitalised in the Children's Clinical University Hospital from April 2013 to December 2015. Genotyping was done for 462 stool samples. Among G/P combinations, the most predominant genotypes were G4P[8] (61.3%), G9P[8] (12.4%) and G2P[4] (10.0%) in children of age 5 years. There was a statistically significant correlation (p < 0.05) between clinical signs (vomiting, dehydration, chronic diseases) and G1P[8] and G8P[8] genotypes. Infants infected with genotype G4P[4] had a statistically significant negative correlation with severity of acute gastroenteritis episodes (p < 0.05). We detected nine different rotavirus G genotypes, and two different P genotypes. G4P[8], G9P[8], and G2P[8] were predominant. We observed correlation between the dominant genotypes and clinical manifestations of rotavirus infection.publishersversionPeer reviewe