Efficient learning of tt-doped stabilizer states with single-copy measurements

One of the primary objectives in the field of quantum state learning is to develop algorithms that are time-efficient for learning states generated from quantum circuits. Earlier investigations have demonstrated time-efficient algorithms for states generated from Clifford circuits with at most $\log(n)$ non-Clifford gates. However, these algorithms necessitate multi-copy measurements, posing implementation challenges in the near term due to the requisite quantum memory. On the contrary, using solely single-qubit measurements in the computational basis is insufficient in learning even the output distribution of a Clifford circuit with one additional $T$ gate under reasonable post-quantum cryptographic assumptions. In this work, we introduce an efficient quantum algorithm that employs only nonadaptive single-copy measurement to learn states produced by Clifford circuits with a maximum of $O(\log n)$ non-Clifford gates, filling a gap between the previous positive and negative results.Comment: 6 page

Physician Acceptance Behavior of the Electronic Medical Records Exchange: An Extended Decomposed Theory of Planned Behavior

In this study, we examined physician acceptance behavior of the electronic medical record (EMR) exchange. Although several prior studies have focused on factors that affect the adoption or use of EMRs, empirical study that captures the success factors that encourage physicians to adopt the EMR exchange is limited. Therefore, drawing on institutional trust integrated with the decomposed theory of planned behavior (TPB) model, we propose a theoretical model to examine physician intentions of using the EMR exchange. A field survey was conducted in Taiwan to collect data from physicians. Structural equation modeling (SEM) using the partial least squares (PLS) method was employed to test the research model. The results showed that the usage intention of physicians is significantly influenced by 4 factors (i.e., attitude, subjective norm, perceived behavior control, and institutional trust). These 4 factors were assessed by their perceived usefulness and compatibility, facilitating conditions and self-efficacy, situational normality, and structural assurance, respectively. The results also indicated that institutional trust integrated with the decomposed TPB model provides an improved method for predicting physician intentions to use the EMR exchange. Finally, the implications of this study are discussed

PATIENTS’ ACCEPTANCE AND RESISTANCE TOWARD THE HEALTH CLOUD: AN INTEGRATION OF TECHNOLOGY ACCEPTANCE AND STATUS QUO BIAS PERSPECTIVES

The latest technological trends such as health cloud provide a strong infrastructure and offer a true enabler for healthcare services over the Internet. Despite its great potential, there are gaps in our understanding of how users evaluate change related to the health cloud and decide to resist it. According to the technology acceptance and status quo bias perspectives, this study develops an integrated model to explain patients’ intention to use and resistance to health cloud services. A field survey was conducted in Taiwan to collect data from patients. The structural equation model was used to examine the data. The results showed that patient resistance to use was caused by inertia, perceived value, and transition costs. Perceived usefulness (PU) and perceived ease of use (PEOU) have positive and direct effects on behavioral intention to use, and PEOU appears to have a positive direct effect on PU. The results also indicated that the relationship between intention to use and resistance to use had a significant negative effect. Our study illustrates the importance of incorporating user resistance in technology acceptance studies in general and health technology usage studies in particular, grounds for a resistance model of resistance that can serve as the starting point for future research in this relatively unexplored yet potentially fertile area of research

Poly[[aqua­(μ2-oxalato)(μ2-2-oxido­pyridinium-3-carboxylato)holmium(III)] monohydrate]

In the title complex, {[Ho(C2O4)(C6H4NO3)(H2O)]·(H2O)}n, the HoIII ion is coordinated by three O atoms from two 2-oxidopyridinium-3-carboxylate ligands, four O atoms from two oxalate ligands and one water mol­ecule in a distorted bicapped trigonal-prismatic geometry. The 2-oxidopyridin­ium-3-carboxylate and oxalate ligands link the HoIII ions into a layer in (100). These layers are further connected by inter­molecular O—H⋯O hydrogen bonds involving the coordinated water mol­ecules to assemble a three-dimensional supra­molecular network. The uncoordin­ated water mol­ecule is involved in N—H⋯O and O—H⋯O hydrogen bonds within the layer

Poly[bis­(4,4′-bipyridine)(μ3-4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ato)iron(II)]

In the polymeric title complex, [Fe(C16H8O8)(C10H8N2)2]n, the iron(II) cation is coordinated by four O atoms from three different 4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ate ligands and two N atoms from two 4,4′-bipyridine ligands in a distorted octa­hedral geometry. The 4,4′-dicarboxybiphenyl-3,3′-di­carboxyl­ate ligands bridge adjacent cations, forming chains parallel to the c axis. The chains are further connected by inter­molecular O—H⋯N hydrogen bonds, forming two-dimensional supra­molecular layers parallel to (010)

Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli

Achieving cellular uptake is a central challenge for novel antibiotics targeting Gram-negative bacterial pathogens. One strategy is to hijack the bacterial iron transport system by siderophore-antibiotic conjugates that are actively imported into the cell. This was realized with the MECAM-ampicillin conjugate LP-600 we recently reported that was highly active against E. coli. In the present study, we investigate a paradoxical regrowth of E. coli upon treatment of LP-600 at concentrations 16-32 times above the minimum inhibitory concentration (MIC). The phenomenon, coined “Eagle-effect” in other systems, was not due to resistance formation, and it occurred for the siderophore conjugate but not for free ampicillin. To investigate the molecular imprint of the Eagle effect, a combined transcriptome and untargeted metabolome analysis was conducted. LP-600 induced the expression of genes involved in iron acquisition, SOS response, and the e14 prophage upon regrowth conditions. The Eagle effect was diminished in the presence of sulbactam, which we ascribe to a putative synergistic antibiotic action but not to β-lactamase inhibition. The study highlights the relevance of the Eagle effect for siderophore conjugates. Through the first systematic -omics investigations, it also demonstrates that the Eagle effect manifests not only in a paradoxical growth but also in unique gene expression and metabolite profiles

MicroRNAs in Bone Diseases: Progress and Prospects

With 19–25 nucleotides long, microRNAs (miRNAs) are small noncoding RNA molecules which play crucial roles in major cellular functions such as cell cycle control, apoptosis, metabolism, cell proliferation, and cell differentiation. Changes in the expression of miRNAs can cause significant effects to normal and aberrant cells. The dysregulation of miRNAs has been implicated in various human diseases such as brain tumor, osteoarthritis, schizophrenia, and breast cancer. Generally, miRNAs negatively regulate gene expression by binding to their specific mRNAs, thereby blocking their translation of the mRNAs. However, a few studies have reported that miRNAs could also upregulate the translation of certain proteins. This shows the important roles of miRNAs in various cell functions. This chapter will focus on the role of miRNAs in normal osteoblast and osteosarcoma cells. In addition, the great potential of miRNA as a new therapeutic approach to treat human bone diseases will also be discussed

Effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals

peer-reviewedFoods are good sources of vitamins, minerals and dietary fibers as well as phytochemicals, which are beneficial for the human body as nutritional supplements. The nutritional value (crude fibers, crude proteins, crude fats, flavonols, carotenoids, polyphenols, glucosinolate, chlorophyll, and ascorbic acid) and biological or functional properties (antioxidant activity, anticancer activity, or anti-mutagenic activity) of foods can be well retained and protected with the appropriate cooking methods. The chemical, physical and enzyme modifications that occur during cooking will alter the dietary phytochemical antioxidant capacity and digestibility. This paper reviewed the recent advances on the effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals. Furthermore, the possible mechanisms underlying these changes were discussed, and additional implications and future research goals were suggested. The domestic cooking process for improving the palatability of foods and increasing the bioavailability of nutrients and bioactive phytochemicals has been well supported