Research on the Management of Student Entrepreneurship Development in Higher Education

Entrepreneurial opportunity identification has attracted much attention in the field of entrepreneurial development as an important factor in the future success of university students in entrepreneurship. Based on experiential learning theory, this study proposes a moderated mediation model to investigate the relationship between entrepreneurial learning (EL) and entrepreneurial opportunity identification, the mediating role of entrepreneurial alertness (EA) and the moderating role of the entrepreneurial environment (EE). A snowball sampling method was used to collect 1263 questionnaires, of which 1164 were valid. The findings revealed that (1) entrepreneurial learning has a positive and significant effect on entrepreneurial opportunity identification among university students; (2) entrepreneurial alertness plays a partially mediating role between entrepreneurial learning and entrepreneurial opportunity identification; (3) entrepreneurial environment plays a moderating role between entrepreneurial learning and entrepreneurial opportunity identification, Compared with a low-level entrepreneurial environment, a high-level entrepreneurial environment can promote the impact

Pre-Treatment with Melatonin Enhances Therapeutic Efficacy of Cardiac Progenitor Cells for Myocardial Infarction

Background/Aims: Melatonin possesses many biological activities such as antioxidant and anti-aging. Cardiac progenitor cells (CPCs) have emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the low survival of transplanted CPCs in infarcted myocardium limits the successful use in treating MI. In the present study, we aimed to investigate if melatonin protects against oxidative stress-induced CPCs damage and enhances its therapeutic efficacy for MI. Methods: TUNEL assay and EdU assay were used to detect the effects of melatonin and miR-98 on H2O2-induced apoptosis and proliferation. MI model was used to evaluate the potential cardioprotective effects of melatonin and miR-98. Results: Melatonin attenuated H2O2-induced the proliferation reduction and apoptosis of c-kit+ CPCs in vitro, and CPCs which pretreated with melatonin significantly improved the functions of post-infarct hearts compared with CPCs alone in vivo. Melatonin was capable to inhibit the increase of miR-98 level by H2O2 in CPCs. The proliferation reduction and apoptosis of CPCs induced by H2O2 was aggravated by miR-98. In vivo, transplantation of CPCs with miR-98 silencing caused the more significant improvement of cardiac functions in MI than CPCs. MiR-98 targets at the signal transducer and activator of the transcription 3 (STAT3), and thus aggravated H2O2-induced the reduction of Bcl-2 protein. Conclusions: Pre-treatment with melatonin protects c-kit+ CPCs against oxidative stress-induced damage via downregulation of miR-98 and thereby increasing STAT3, representing a potentially new strategy to improve CPC-based therapy for MI

Impacts of Sand Mining Activities on the Wetland Ecosystem of Poyang Lake (China)

Increasing anthropogenic activities are threatening freshwater ecosystems worldwide. Sand mining in Poyang Lake has significantly impacted the wetland ecosystem over the past 20 years, yet a quantitative analysis of these impacts remains insufficient. Here, we used 63 Landsat images taken from 2000 to 2020 along with the support vector machine (SVM) method and a retrieval model of suspended sediment concentration (SSC) to identify sand mining vessels and areas affected by sand mining. Then, we analyzed the changes in landscape patterns in the areas affected by sand mining. The potential impact of underwater noise generated by sand mining vessels on Yangtze finless porpoises was analyzed by a sound propagation model. The number of sand mining vessels in Poyang Lake during the flood, normal, and dry seasons increased from 2000 to 2016 but rapidly decreased from 2017 to 2020. Sand mining vessels were mainly distributed in the northern channel from 2000 to 2006, moved toward the center of the lake from 2007 to 2010, then moved northward in 2017. Within the areas affected by sand mining, water and mudflats declined, grassland and sandbars increased, and the landscape discontinuity increased. The habitat of the Yangtze finless porpoise affected by underwater noise from sand mining vessels in all seasons has significantly increased overtime. The mean area of the affected habitats was 70.65% (dry), 64.48% (normal), and 63.30% (flood) of the total habitat areas. The porpoise habitats in the northern channel and the west branch of the Ganjiang River are more seriously affected by the underwater noise of sand mining vessels than the southern lake. The impact of sand mining activities on wetland landscape and aquatic species demands systematic investigation in the future

Stem Cell-Derived Exosome in Cardiovascular Diseases: Macro Roles of Micro Particles

The stem cell-based therapy has emerged as the promising therapeutic strategies for cardiovascular diseases (CVDs). Recently, increasing evidence suggest stem cell-derived active exosomes are important communicators among cells in the heart via delivering specific substances to the adjacent/distant target cells. These exosomes and their contents such as certain proteins, miRNAs and lncRNAs exhibit huge beneficial effects on preventing heart damage and promoting cardiac repair. More importantly, stem cell-derived exosomes are more effective and safer than stem cell transplantation. Therefore, administration of stem cell-derived exosomes will expectantly be an alternative stem cell-based therapy for the treatment of CVDs. Furthermore, modification of stem cell-derived exosomes or artificial synthesis of exosomes will be the new therapeutic tools for CVDs in the future. In addition, stem cell-derived exosomes also have been implicated in the diagnosis and prognosis of CVDs. In this review, we summarize the current advances of stem cell-derived exosome-based treatment and prognosis for CVDs, including their potential benefits, underlying mechanisms and limitations, which will provide novel insights of exosomes as a new tool in clinical therapeutic translation in the future

Retracted Article: A Study on the Impact of Anxiety on the Perception of Communication Engineering Teachers about Self-Efficacy

This article has been retracted by the iJET editorial team: The article on this page has been associated with fraudulent publication practices after its publication in iJET. The work could be linked to a criminal paper mill selling authorships and articles for publication in several online journals to paying customers. The iJET editorial team was initially informed about the paper mill’s fraudulent activities by Dr. Perron (University of Michigan) and his team on 08/03/2021. The investigation results were published on RetractionWatch under https://retractionwatch.com/author/perronetal/ on 12/20/2021. Based on the evidence provided by Dr. Perron and his team, the iJET editorial team considerably questions the paper’s scientific integrity and legitimacy as part of the scientific body. Finally, iJET decided to retract the paper. Neither iJET, Online-Journals.org, nor IAOE stands in any contact with the paper mill’s fraudulent activities. We condemn such procedures and dissociate ourselves from any person or entity, which is knowingly or unknowingly part of it

Identifying High Stranding Risk Areas of the Yangtze Finless Porpoise via Remote Sensing and Hydrodynamic Modeling

Freshwater cetaceans that inhabit river basins with seasonally changing hydrological regimes have a higher risk of stranding, leading to increased mortality and population decline. In Poyang Lake, the stranding risk of the critically endangered Yangtze finless porpoise are high, due to the significant differences in hydrological and landscape conditions between the flood and dry seasons. However, this stranding information is not well recorded, resulting in poorly guided investigation and rescue efforts. We here employ remote sensing and hydrodynamic modeling to obtain four evaluation indicators in dry, normal, and flood scenarios in Poyang Lake. Results show that nearly 50% of the largest habitat range of the porpoises in the flood season will be land areas during the dry season, and that landscape fragmentation between land and water has increased over the past three decades. In all scenarios, the mean water depth of the habitat varied from 1.77 to 4.89 m from September–February. In the dry scenario, about 59% of the habitat experiences a water depth of 2 in the dry scenario, >251.04 km2 in the normal scenario, and >90.12 km2 in the flood scenario. High-stranding risk areas are located within city boundaries, where porpoise stranding cases have been recorded, especially in Duchang, which has the most high-risk areas in all scenarios. In all scenarios, the high stranding risk area has an average bathymetry of 7.81 m and an average water depth between 1.75 and 5.54 m. Our results can guide future investigations to establish sound stranding networks, and the methods proposed here are also applicable to studies of other freshwater cetaceans facing severe stranding risk

Identifying High Stranding Risk Areas of the Yangtze Finless Porpoise via Remote Sensing and Hydrodynamic Modeling

Freshwater cetaceans that inhabit river basins with seasonally changing hydrological regimes have a higher risk of stranding, leading to increased mortality and population decline. In Poyang Lake, the stranding risk of the critically endangered Yangtze finless porpoise are high, due to the significant differences in hydrological and landscape conditions between the flood and dry seasons. However, this stranding information is not well recorded, resulting in poorly guided investigation and rescue efforts. We here employ remote sensing and hydrodynamic modeling to obtain four evaluation indicators in dry, normal, and flood scenarios in Poyang Lake. Results show that nearly 50% of the largest habitat range of the porpoises in the flood season will be land areas during the dry season, and that landscape fragmentation between land and water has increased over the past three decades. In all scenarios, the mean water depth of the habitat varied from 1.77 to 4.89 m from September–February. In the dry scenario, about 59% of the habitat experiences a water depth of <1 m within 15 days. The high stranding risk area is 284.54 km2 in the dry scenario, >251.04 km2 in the normal scenario, and >90.12 km2 in the flood scenario. High-stranding risk areas are located within city boundaries, where porpoise stranding cases have been recorded, especially in Duchang, which has the most high-risk areas in all scenarios. In all scenarios, the high stranding risk area has an average bathymetry of 7.81 m and an average water depth between 1.75 and 5.54 m. Our results can guide future investigations to establish sound stranding networks, and the methods proposed here are also applicable to studies of other freshwater cetaceans facing severe stranding risk

Residual Stress, Microstructure and Mechanical Properties in Thick 6005A-T6 Aluminium Alloy Friction Stir Welds

Plates (37 mm thick) of 6005A-T6 aluminum alloy were butt joined by a single-sided and double-sided friction stir welding (FSW). The 3D residual stresses in the joints were determined using neutron diffraction. The microstructures were characterized by a transmission electron microscope (TEM) and electron backscatter diffraction (EBSD). In the single-sided FSW specimen, there were acceptable mechanical properties with a tensile strength of 74.4% of base metal (BM) and low residual stresses with peak magnitudes of approximately 37.5% yield strength of BM were achieved. The hardness is related to the grain size of the nugget zone (NZ), and in this study, precipitations were dissolved due to the high heat input. In the double-sided FSW specimen, there were good mechanical properties with a tensile strength of 80.8% of BM, but high residual stresses with peak magnitudes of approximately 70% yield strength of BM were obtained. The heat input by the second pass provided an aging environment for the first-pass weld zone where the dissolved phases were precipitated and residual stresses were relaxed