8 research outputs found
Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP
Get PDFCannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical evaluation of a new CB1R specific radiotracer, [18F]FPATPP. [18F]FPATPP was produced with 16.7 ± 5.7% decay-corrected radiochemical yield and >95 GBq/μmol molar activity. The tracer showed high stability, low defluorination, and high specific binding to CB1Rs in mouse brain.</p
Oxidants and Tyrosine Phosphorylation: Role of Acute and Chronic Oxidative Stress in T-and B-Lymphocyte Signaling
No full textTranscriptional Activation and Redox Regulation of the Tumor Necrosis Factor-α Promoter in Human T Cells: Role of the CRE/κ3 Promoter Region
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