The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

An Examination of the Media Portrayal of Femicide–Suicides: An Exploratory Frame Analysis

Recent research has been focused on the portrayal of intimate partner homicides in the news media with specific emphasis on the most commonly occurring type, femicides (the murder of a female intimate partner by a male intimate partner). One important finding in the analysis of intimate partner homicide is the striking number of femicides that are followed by perpetrator suicide. Whereas homicide followed by suicide is a rare occurrence in the context of crime generally, within the context of intimate partner homicide, femicide–suicide is common. The present research utilized content analysis to explore the media coverage of a near population of femicide–suicide cases in the North Carolina from 2002 to 2009 (n = 86). An examination of the article titles showed that the majority of titles (54%) assigned to the articles describe the crime as an ambiguous homicide or homicide–suicide and do not indicate the relationship between the perpetrator and victim. In comparison, results show that 78% of the articles’ text defined the homicide–suicide as domestic violence. Specifically, in cases where the news coverage defined the femicide–suicide as domestic violence, the authors identified 4 media frames used (1) femicide–suicide by a male perpetrator, (2) femicide–suicide due to loss of perpetrator control, (3) femicide–suicide as a mercy killing, and (4) femicide–suicide due to jealousy. Implications for societal perceptions of violence against women as well as corresponding victims’ policies/services are presented and discussed