Sinteza, antibakterijsko i potencijalno anti-HIV djelovanje nekoliko novih analoga imidazola

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylamino-propan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H- imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.Sintetizirana je serija 1-(2-metil-4-nitro-imidazol-1-il)-3-arilamino-propan-2-ona (2a-e), 2-metil-5-nitro-1-{2-[arilmetoksi]etil}-1H- imidazola (5a-d) i N-(3-hidroksifenil)-2-(supstituiranih imidazol-1-il)alkanamida (8a-e) s ciljem dobivanja novih derivata imidazola sa širokim kemoterapijskim svojstvima. Navedeni spojevi ispitani su na anti-HIV i antibakterijsko djelovanje