3 research outputs found
Učinak levamisol hidroklorida na titrove protutijela za slinavku i šap u krvnom serumu i kolostrumu u cijepljenih bivolica (Bubalus bubalis).
A study was conducted to ascertain whether post-vaccination antibody titres in serum and colostrum against foot and mouth disease virus in pregnant buffaloes (Bubalus bubalis) could be enhanced by simultaneous administration of levamisole hydrochloride. Twenty-four pregnant buffaloes were divided into three groups of equal size: unvaccinated, vaccinated control, and levamisole-treated vaccinated. The vaccination was given 10 weeks prior to expected parturition. Weekly serum samples were collected until parturition, while colostrum samples were obtained within 1h after parturition. Passive haemagglutination test was applied to determine antibody titres. Levamisole-treated animals showed a progressive rise in antibody titre until week 6, reaching a peak value of 70.0 ± 4.3 (SD) during that same week. Levamisole hydrochloride significantly (P<0.05) increased antibody titres in serum, although results of statistical analysis of colostral antibody titres were not significantly different between experimental groups.Istraživanje je provedeno da se utvrdi da li se može post-vakcinalni titar protutijela za slinavku i šap u serumu i u kolostrumu gravidnih bivolica povečati istovremenim davanjem levamisol hidroklorida. Dvadeset i četiri gravidne bivolice (Bubalus bubalis) su podijeljene u 3 jednake skupine: necijepljene, cijepljene kontrolne i cijepljene uz tretman levamisolom. Cijepivo je davano 10 tjedana prije očekivanog telenja. Tjedni uzorci seruma su uzimani do telenja, a kolostruma 1 sat nakon telenja. Za utvr|ivanje titra protutijela rabljen je test pasivne hemaglutinacije. Životinje tretirane levamisolom pokazale su progresivan rast titra protutijela do šestog tjedna kada su dosegle najvišu vrijednost od 70,0±4,3 (SD). Levamisol hidroklorid je značajno (P<0,05) povisio titar protutijela u serumu ali se rezultati statističke analize titra kolostralnih protutijela nisu značajno razlikovali među skupinama pokusnih životinja