The Use of Phage-Displayed Peptide Libraries to Develop Tumor-Targeting Drugs

Monoclonal antibodies have been successfully utilized as cancer-targeting therapeutics and diagnostics, but the efficacies of these treatments are limited in part by the size of the molecules and non-specific uptake by the reticuloendothelial system. Peptides are much smaller molecules that can specifically target cancer cells and as such may alleviate complications with antibody therapy. Although many endogenous and exogenous peptides have been developed into clinical therapeutics, only a subset of these consists of cancer-targeting peptides. Combinatorial biological libraries such as bacteriophage-displayed peptide libraries are a resource of potential ligands for various cancer-related molecular targets. Target-binding peptides can be affinity selected from complex mixtures of billions of displayed peptides on phage and further enriched through the biopanning process. Various cancer-specific ligands have been isolated by in vitro, in vivo, and ex vivo screening methods. As several peptides derived from phage-displayed peptide library screenings have been developed into therapeutics in current clinical trials, which validates peptide-targeting potential, the use of phage display to identify cancer-targeting therapeutics should be further exploited

The New Urban Leaders

By Joyce A. Ladner Brookings Institution Press (Hardcover, $22.95, ISBN: 0815751087, 10/2001) In The New Urban Leaders, Joyce Ladner, a Senior Fellow at the Brookings Institution, profiles some 25 appointed heads of nonprofit community-based urban organizations. Aimed at community activists and leaders, the book includes close studies of a few including Robert Moses, a civil rights era activist who now heads The Algebra Project and the Rev. Eugene Rivers, who fights gang violence in Boston and a broader analysis of how to build such leadership nationally. ―Copyright 2001 Cahners Business Information, Inc.https://egrove.olemiss.edu/mwp_books/1380/thumbnail.jp

The Ties That Bind: Timeless Values for African American Families

Nonfiction by Joyce A. Ladner John Wiley & Sons (Hardcover, $22.95, ISBN: 0471199532, 1/1999; Paperback,$14.95, ISBN: 0471199532, 12/2000) How do we strengthen our children\u27s souls? How do we fortify them with a sense of obligation, hope, faith, trust, and a burning desire to achieve? In this wise and important book, you will discover unlimited answers that are yours for the taking―the keys to raising children with strong values and a positive sense of purpose and identity. Today\u27s children―many of them blessed with more material wealth and education than any generation before―greet the world with a sense of uneasiness at best, and, at worst, a sense of despair. In The Ties That Bind, Dr. Joyce Ladner, an eminent sociologist, shows how we can empower more children with the self-confidence that will sustain them throughout their lives. Keeping the promise of her own tradition-rich Mississippi upbringing, Dr. Ladner passes on the timeless treasure of African American values. A leading scholar and activist, she reveals how each generation taught the next a vital set of lessons in values. Drawing insight from everyday heroes, family stories, and personal experiences as a mother of a growing son, she brings those lessons to life and shapes them for our times. Step by step, she teaches the authentic principles of the historic black value system. Finally, she demonstrates how you can pass on this legacy in a way that children will absorb through dozens of simple, everyday activities for home, church, school, and community life. The Ties That Bind will help you give your children the foundation they need through their growing years and beyond. Let this enriching book with its healing lessons guide and nourish your family.https://egrove.olemiss.edu/mwp_books/1408/thumbnail.jp

Launching Our Black Children for Success: A Guide for Parents of Kids from Three to Eighteen

By Joyce A. Ladner and Theresa Foy DiGeronimo John Wiley & Sons (Paperback, $17.95, ISBN: 0787964883, 6/2003) “Launching Our Black Children for Success is right on target in emphasizing that parenting black youth requires supporting them at home to develop a strong sense of self-worth while working on their behalf outside of the home to bring about social change to ensure equal opportunity for every African American child. Absorbing the lessons outlined in this important book will greatly contribute to the strengths of black children and their families.”—From the Foreword by Alvin F. Poussaint, M.D. Launching Our Black Children for Success is a groundbreaking book that goes beyond the typical “how to get your kid into the best school or college” advice. This extraordinary book takes black parents step-by-step through the stages of child development so they can build a solid foundation for success in their children. It shows how to best instill pride, self-discipline, social skills, a work ethic, and a way to deal with the inevitable racism and prejudice their children will face. Authors Joyce Ladner and Theresa Foy DiGeronimo also offer a practical guide for overcoming the many injustices and obstacles African American families face and show how to shepherd their kids through the process that is required to help children keep their “eyes on the prize.” Launching Our Black Children for Success helps parents to provide the strength and the strategies their children need to seek out whatever career they dream of and deserve.https://egrove.olemiss.edu/mwp_books/1177/thumbnail.jp