11 research outputs found
Allosteric effects in cyclophilin mutants may be explained by changes in nano-microsecond time scale motions
Get PDFThe relationship between molecular motion and catalysis in enzymes is debated. Here, simulations of cyclophilin A and three catalytically-impaired mutants reveal a nanosecond-scale interconversion between active and inactive conformations, orders of magnitude faster than previously suggested
A Convenient One-Pot Synthesis of Some New 3-(2-Phenyl-6-(2-thienyl)-4-pyridyl)hydroquinolin-2-ones Under Microwave Irradiation and Their Antimicrobial Activities
No full textSynthesis of novel thiopyrimidines: an investigation of anti-tubercular and antimicrobial activity
No full textTetrazoloquinoline-1,2,3-Triazole Derivatives as Antimicrobial Agents: Synthesis, Biological Evaluation and Molecular Docking Study
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Conformation-Directed Catalysis and Coupled Enzyme–Substrate Dynamics in Pin1 Phosphorylation-Dependent Cis–Trans Isomerase
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