Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa

Division of Translational and Clinical Oncolog

Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype

Division of Translational and Clinical Oncolog

Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm

Objective:\ud To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).\ud \ud Methods:\ud Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (1360C > T, and þ649C > T) in men with AAA (nZ678) and in\ud controls (nZ659) was examined using multivariate analyses. The association with AAA expansion (nZ638) was also assessed.\ud \ud Results:\ud In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.\ud \ud Conclusion:\ud MMP2 1360C > T and þ649C > T variants are not risk factors for AAA. ª 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved