1 research outputs found
Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays
Research conducted under this RWO from July 1, 1997 through June 30, 2000 has
provided important new information about the pathogenesis, virology, and
immunology of marine turtle fibropapillomatosis. In particular, we have provided
strong evidence for the association of a herpesvirus with fibropapillomatosis of the
green turtle,Chelonia mydas, and the loggerhead turtle, Caretta caretta, in Florida. In
addition we have provided new evidence for the absence of papillomaviruses from
sea turtle fibropapillomas. Although unsuccessful, important new attempts were made
to cultivate the FP-associated herpesvirus in vitro in collaboration with the National
Wildlife Health Center. During this period of time, we completed publication of the first
comprehensive description of the comparative pathology and pathogenesis of
experimentally induced and spontaneous fibropapillomas of green turtles (Chelonia
mydas). We initiated innovative studies on the persistence of a Chelonian
herpesviruses in the marine environment demonstrating for the first time that the
environmental survivability of Chelonian herpesviruses makes them real threats to
marine turtle health. Finally, we explored development of a serological assay for FP
using synthetic herpesvirus peptides and developed methodologies for detection of
antibodies to LETV [Iung-eye-trachea virus] a disease-associated herpesvirus of the
green turtle, Chelonia mydas.. This last initiative is ongoing and will further our efforts
to develop specific immunological assays for the FP-associated herpesvirus and FP. (17 page document