9 research outputs found
Role of deamidated gliadin peptide antibodies in celiac children less than two years with only conventional AGA positive
Sensitivity and specificity for IgA and IgG antibodies to deamidated gliadin peptides in celiac disease children less than two years
Cytomegalovirus infection in immunocompetent children with gastrointestinal (GI) involvement
Gastrointestinal (GI) involvement by cytomegalovirus infection in immunocompetent children
A Prospective, Open-label, Single-centre Trial to Evaluate Efficacy and Safety of Adalimumab in Children With Active Crohn Disease
Sicurezza dell\u2019Infliximab in bambini con malattia infiammatoria cronica intestinale (IBD): Registro pediatrico italiano di terapia biologica per le IBD. Studio multicentrico della societ\ue0 italiana di gastroenterologia, epatologia e nutrizione pediatrica (SIGENP).
Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy
Antiretroviral use in Italian children with perinatal HIV infection over a 14-year period.
BACKGROUND: Information on the use of new antiretroviral drugs in children in the real setting of clinical fields is largely unknown.
METHODS: Data from 2554 combined antiretroviral therapy (cART) regimens administered to 911 children enrolled in the Italian Register for HIV infection in children, between 1996 and 2009, were analysed. Factors potentially associated with undetectable viral load and immunological response to cART were explored by Cox regression analysis.
RESULTS: Proportion of protease inhibitor (PI)-based regimens significantly decreased from 88.0% to 51.2% and 54.9%, while proportion on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens increased from 4.5% to 38.8% and 40.2% in 1996-1999, 2000-2004 and 2005-2009, respectively (p < 0.0001). Significant change in the use of each antiretroviral drug occurred over the time periods (p < 0.0001). Factors independently associated with virological and immunological success were as follows: later calendar periods, younger age at regimen (only for virological success) and higher CD4(+) T-lymphocyte percentage at baseline. Use of unboosted PI was associated with lower adjusted hazard ratio (aHR) of virological or immunological success with respect to NNRTI- and boosted PI-based regimens, with no difference among these two latter types.
CONCLUSION: Use of new generation antiretroviral drugs in Italian HIV-infected children is increasing. No different viro-immunological outcomes between NNRTI- and boosted PI-based cART were observe