2 research outputs found
Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation.
The aim of the study was to assess lung function longitudinally after neonatal
extracorporeal membrane oxygenation (ECMO), and to identify any effects of
diagnosis and perinatal characteristics. 121 neonatal ECMO-treated children (70
with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with
other diagnoses) performed a total of 191 lung function measurements at 5, 8
and/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of
airway obstruction and diffusion capacity. Mean SDS forced expiratory volume in 1
s (FEV(1)) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was
significantly higher than at 8 (-0.79 and -0.4; p<0.04) and 12 yrs (-1.10 and
-0.52; p<0.003). Mean SDS for all spirometric parameters before and after
bronchodilation were significantly lower in the congenital diaphragmatic hernia
group compared with the other diagnostic groups (all p</=0.025). A significant
volume of trapped air was observed in 86% patients with congenital diaphragmatic
hernia, 50% with meconium aspiration syndrome and 58% with other diagnoses. After
bronchodilation, mean SDS FEV(1) and forced vital capacity were negatively
influenced by duration of ventilation (both p<0.001) and duration of ECMO
(p=0.003 and p=0.02, respectively). Long-term pulmonary sequelae after neonatal
ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend
to deteriorate over time