3 research outputs found
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection
Physical Activity and Health Outcomes Among HIV-Infected Men Who Have Sex with Men: A Longitudinal Mediational Analysis
BACKGROUND: Low physical activity is associated with depression, which may in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence. PURPOSE: To examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men. METHODS: The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care. RESULTS: Across time, depression mediated the relationship between physical inactivity and ART non-adherence, γ = .075, and the relationship between physical inactivity and viral load, γ = .05. ART non-adherence mediated the relationship between depression and viral load, γ = .002, and the relationship between physical inactivity and viral load, γ = .009. CONCLUSIONS: Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load