102 research outputs found
Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
- Author
- A Bailey
- A Pickles
- A Slopien
- Ann L. Collins
- C Lord
- CD Elliott
- CM Wolpert
- D Dhossche
- D Wechsler
- D Zaykin
- Deqiong Ma
- DQ Ma
- E Fombonne
- E Fombonne
- E Fombonne
- E Fombonne
- E Maestrini
- Eden R. Martin
- EL Nurmi
- EM Mullen
- ER Martin
- ER Martin
- ER Ritvo
- GH Roid
- GJ Blatt
- GR Abecasis
- Harry H. Wright
- JD Buxbaum
- JG Williams
- JM Vance
- John P. Hussman
- John R. Gilbert
- Jonathan L. Haines
- JP Hussman
- LH Rolf
- LW Hahn
- M Rutter
- M Yeargin-Allsopp
- Margaret A. Pericak-Vance
- MD Ritchie
- Michael L. Cuccaro
- ML Bauman
- N Risch
- Patrice L. Whitehead
- RL Macdonald
- Ruth K. Abramson
- S Bundey
- S Horvath
- SH Fatemi
- SL Smalley
- SS Sparrow
- Y Shao
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2006
- Field of study
Autism is a neurodevelopmental disorder of complex genetics, characterized by impairment in social interaction and communication, as well as repetitive behavior. Multiple lines of evidence, including alterations in levels of GABA and GABA receptors in autistic patients, indicate that the GABAergic system, which is responsible for synaptic inhibition in the adult brain, may be involved in autism. Previous studies in our lab indicated association of noncoding single nucleotide polymorphisms (SNPs) within a GABA receptor subunit gene on chromosome 4, GABRA4, and interaction between SNPs in GABRA4 and GABRB1 (also on chromosome 4), within Caucasian autism patients. Studies of genetic variation in African-American autism families are rare. Analysis of 557 Caucasian and an independent population of 54 African-American families with 35 SNPs within GABRB1 and GABRA4 strengthened the evidence for involvement of GABRA4 in autism risk in Caucasians (rs17599165, p=0.0015; rs1912960, p=0.0073; and rs17599416, p=0.0040) and gave evidence of significant association in African-Americans (rs2280073, p=0.0287 and rs16859788, p=0.0253). The GABRA4 and GABRB1 interaction was also confirmed in the Caucasian dataset (most significant pair, rs1912960 and rs2351299; p=0.004). Analysis of the subset of families with a positive history of seizure activity in at least one autism patient revealed no association to GABRA4; however, three SNPs within GABRB1 showed significant allelic association; rs2351299 (p=0.0163), rs4482737 (p=0.0339), and rs3832300 (p=0.0253). These results confirmed our earlier findings, indicating GABRA4 and GABRB1 as genes contributing to autism susceptibility, extending the effect to multiple ethnic groups and suggesting seizures as a stratifying phenotype
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
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- A Matsuzawa
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- A Murakami
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- A Murakami
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- A Nijnik
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- A Nunomura
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- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
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- A Wagner
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- A Wong
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Performance evaluation of a discovery and scheduling protocol for multihop ad hoc mobile grids
- Author
- A Erramilli
- A Litke
- A Varshavsky
- Antônio Tadeu Azevedo Gomes
- Artur Ziviani
- ATA Gomes
- ATA Gomes
- C Dabrowski
- C Lee
- C Weng
- CE Perkins
- CN Ververidis
- CQ Huang
- D Abramson
- D Chakraborty
- D Hughes
- D Johnson
- D Johnson
- Defense Advanced Research Projects Agency — DARPA
- F Berman
- Information Sciences Institute — ISI
- J Frey
- J Huang
- J Hwang
- K Czajkowski
- K Kagawa
- K Katsaros
- KA Hummel
- L Wolf
- Luciana dos Santos Lima
- LW McKnight
- M Gaynor
- M Waldburger
- Markus Endler
- N Rouphail
- PA Dinda
- PJ Denning
- SB Priva
- SY Ni
- SY Wang
- T Camp
- V Lenders
- V Sacramento
- W Smith
- WJ Bolosky
- Z Zong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
- Author
- A Andersson
- A Berghella
- A Ceccarelli
- A Chaudhuri
- A Damasceno
- A Fiorini
- A Gardner
- A Kuchinad
- A Massara
- A Nagano-Saito
- A Nancy
- A Penn
- A Perl
- A Perl
- A Sabry
- A Sivro
- A Yamamoto
- AD Kohl
- AG Beiske
- AH Miller
- AH Rahman
- AH Schapira
- AH Tsang
- AJ Hartz
- AJ Wearden
- AJ Wysenbeek
- AL Lopresti
- AM Al Dhanhani
- AR Light
- AT White
- B Campillo
- B Chandran
- B Cillero-Pastor
- B Cillero-Pastor
- B Leonard
- B Segal
- B Segal
- BK Puri
- BK Puri
- C Blake
- C Brosnan
- C Dalton
- C Guevara
- C Heesen
- C Heesen
- C Holmes
- C Huang
- C Huang
- C Kim
- C Kowal
- C Lafitte
- C Pellicano
- C Perricone
- C Ramos-Remus
- C Schmidt
- C Song
- C Stavropoulou
- C Wang
- CC Ferrari
- CC Mok
- CH Polman
- CM Greco
- CP Mavragani
- CW Shults
- D Arnone
- D Blum-Degen
- D Brooks
- D Centonze
- D Chen
- D Costa Da
- D Horakova
- D Krige
- D Lindqvist
- D Londoño
- D Mahad
- D Maimone
- D Reif
- D Zdrenghea
- DB Cook
- DC Shungu
- DE Jones
- DJ Mahad
- DL Arnold
- DM Keeling
- E Bora
- E Esposito
- E Hagiwara
- E Harboe
- E Miller
- E Muscal
- E Patrick
- EA Ko
- EH Tobe
- EK Lindersson
- EK Tensing
- EL Alexander
- EM Duffy
- EW Brenu
- EW Brenu
- F Brentano
- F Goh
- F Lu
- F Veerdonk van de
- FC Soliotis
- FP Lange de
- FP Lange de
- G Alves
- G Anderson
- G Broderick
- G Castellino
- G Katsifis
- G Kennedy
- G Lazzarino
- G Morris
- G Morris
- G Morris
- G Morris
- G Morris
- G Morris
- G Morris
- G Morris
- G Nagy
- G Pagano
- G Schifitto
- G Tedeschi
- G Tobón
- G Wang
- GE Ahn
- Gerwyn Morris
- GG Ortiz
- GN Pandey
- GP Holmes
- GR Morrow
- H Arai
- H Chen
- H Cui
- H Genova
- H Kuper
- H Lee
- H Manji
- H Marin
- H Marin
- H Repping-Wuts
- H Repping-Wuts
- H Repping-Wuts
- H Westerlind
- HI Bax
- HM Gao
- HM Lee
- HM Markusse
- HZ Low
- I Bakken
- I Giles
- I Gárate
- I Jialal
- I Ku
- I Rektorova
- J Angst
- J Anrather
- J Bas
- J Beck
- J Birnbaum
- J DeLuca
- J Iriarte
- J Martinot
- J Peng
- J Romme Christensen
- J Steiner
- J Steiner
- J Stobart
- J Xia
- JB Koprich
- JH Friedman
- JJ Hilten van
- JM Kremer
- JM Kremer
- JP Hamilton
- JW Gow
- JW Murrough
- K Filler
- K Fukuda
- K Haldorsen
- K Hisanaga
- K Kamagata
- K Liepe
- K Lucas
- K Miwa
- K Mori
- K Norheim
- K Norheim
- K Wartolowska
- K Yoshiuchi
- Ken Walder
- KG Hollingsworth
- KJ Maher
- KK McCully
- KK McCully
- KR Chaudhuri
- L Bindoff
- L Borish
- L Debernard
- L Fellner
- L Haider
- L Harel
- L Lorusso
- L Munoz
- L Pierot
- L Schiebinger
- L Tzarouchi
- LA DeGiorgio
- LB Krupp
- LB Krupp
- LB Krupp
- LC Pollard
- LR Barnden
- LW Moreland
- M Aringer
- M Aringer
- M Benkler
- M Berk
- M Blinkenberg
- M Bombardieri
- M Bsibsi
- M Calabrese
- M Calabrese
- M Du
- M Dufek
- M Fava
- M Feldmann
- M Fernández-Seara
- M Filippi
- M Fukuda
- M Fukuda
- M Gironi
- M Ichise
- M Inglese
- M Inglese
- M Kool
- M Lauvsnes
- M Lubomski
- M Maes
- M Maes
- M Maes
- M Maes
- M Maes
- M Maes
- M Maes
- M Maes
- M Maes
- M Moreno
- M Nakamura
- M Niethammer
- M Ota
- M Pfreundschuh
- M Piccinelli
- M Rana
- M Rango
- M Reale
- M Sariyildiz
- M Sisto
- M Sofroniew
- M Sultani
- M Sárvári
- M Tsuda
- M Valcárcel-Ares
- M Voulgarelis
- ME Weinblatt
- MG Tansey
- Michael Berk
- Michael Maes
- MJ Kempton
- MJ Mentis
- MJ Morgan
- N Akhyani
- N Hirono
- N Jacob
- N Khansari
- N Oberheim
- N Sattar
- N Shao
- N Tellez
- N Tellez
- N Tiffin
- NE Booth
- NG Klimas
- NW Lutz
- NW Lutz
- O Blin
- O Vera-Lastra
- P Alex
- P Barone
- P Borghammer
- P Flachenecker
- P Flachenecker
- P Hagell
- P Nagyoszi
- P Panopalis
- P Pittman
- P Scalzo
- P Szodoray
- P Tak
- P Youinou
- PJ Barendregt
- PM Keeney
- PR Fortin
- Q Huang
- R Acín-Pérez
- R Alvarez-Lafuente
- R Bakshi
- R Bakshi
- R Dutta
- R Fernandez-Gonzalo
- R Haas
- R Henry
- R Jung
- R Manthorpe
- R Patarca
- R Ramsey-Goldman
- R Stasi
- R Wong
- RB Moss
- RC Vermeulen
- RC Vermeulen
- RE Gonsette
- RE Keyser
- RF Peppard
- RJ Dobbs
- RJ Lane
- RL Mosley
- S Appenzeller
- S Appenzeller
- S Fulle
- S Goldman
- S Grieve
- S Hassan
- S Hewlett
- S Hewlett
- S Hostenbach
- S Kundu
- S Lisi
- S Ljubisavljevic
- S Machale
- S Messina
- S Miranda-Hernandez
- S Munoz-Cruz
- S Myhill
- S Myhill
- S Nakata
- S Oertelt-Prigione
- S Pal
- S Reinke
- S Rose
- S Schutzer
- S Shinde
- S Terada
- S Tukaj
- S Walther
- SB Abramson
- SI Bekkelund
- SJ Mathew
- SL Hauser
- SM Gold
- SP Tabruyn
- SR Oliveira
- ST Sonis
- ST Sonis
- SW Yong
- T Dhaouadi
- T Farooqui
- T Gono
- T Gono
- T Ho
- T Hosokawa
- T Kreisel
- T Okada
- T Siessmeier
- T Sylva Da
- TB Sherer
- TC Frank-Cannon
- TH Wakamatsu
- U Ellfolk
- U Roelcke
- U Tirelli
- V Marian
- V Navikas
- VH Perry
- VH Perry
- VH Perry
- VH Perry
- WD Parker Jr
- WF Ng
- WM Behan
- WM Behan
- WU Kim
- X Caseras
- Y Baba
- Y Hosokai
- Y Imaizumi
- Y Lapierre
- Y Mizuno
- Y Turan
- YC Chung
- YT Konttinen
- Z Meszaros
- Z Yan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Moiré Patterns and Hologram Interferometry
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global method for stability analysis of anchored slopes
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Slope inclinometers for landslides
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Back analysis of an excavated slope failure in highly fractured rock mass: the case study of Kargar slope failure (Iran)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Geotechnical and hydrochemical properties of sewage sludge
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Congenital supraglottic cyst: A rare cause of stridor
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …