113 research outputs found
Comparison between harvesting and preserving the spinous process for adolescent idiopathic scoliosis
Assessing mechanical integrity of spinal fusion by in situ endochondral osteoinduction in the murine model
<p>Abstract</p> <p>Background</p> <p>Historically, radiographs, micro-computed tomography (micro-CT) exams, palpation and histology have been used to assess fusions in a mouse spine. The objective of this study was to develop a faster, cheaper, reproducible test to directly quantify the mechanical integrity of spinal fusions in mice.</p> <p>Methods</p> <p>Fusions were induced in ten mice spine using a previously described technique of in situ endochondral ossification, harvested with soft tissue, and cast in radiolucent alginate material for handling. Using a validated software package and a customized mechanical apparatus that flexed and extended the spinal column, the amount of intervertebral motion between adjacent vertebral discs was determined with static flexed and extended lateral spine radiographs. Micro-CT images of the same were also blindly reviewed for fusion.</p> <p>Results</p> <p>Mean intervertebral motion between control, non-fused, spinal vertebral discs was 6.1 ± 0.2° during spine flexion/extension. In fusion samples, adjacent vertebrae with less than 3.5° intervertebral motion had fusions documented by micro-CT inspection.</p> <p>Conclusions</p> <p>Measuring the amount of intervertebral rotation between vertebrae during spine flexion/extension is a relatively simple, cheap (<$100), clinically relevant, and fast test for assessing the mechanical success of spinal fusion in mice that compared favorably to the standard, micro-CT.</p
Anterior surgical management of the cervicothoracic junction lesions at T1 and T2 vertebral bodies
Patient engagement with surgical site infection prevention: an expert panel perspective
A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes
Visualização radiológica intraoperatória em cirurgias da região cervicotorácica: Nota técnica
The “open book” technique for preparation of the lumbar transverse process for posterolateral fusion
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