28 research outputs found
Índice de Massa Corporal, Idade, Maturação Sexual e a Incidência de Hiperlordose Lombar em crianças e adolescentes
Introduction: Hyperlordosis can cause several degenerative spinal pathologies in children and adolescents.
Objective: Determine whether body mass index, age and sexual maturation predict the occurrence of hyperlordosis in children and adolescents. Method: The study analyzed 380 students aged between 10 and 18 years. Body mass index was evaluated using the reference values suggested by the Fitnessgram test battery, and sexual maturation through Tanner’s scale of self-assessed pubic hair growth. Postural assessment was conducted using the DIPA photogrammetry method, version 3.1. (Digital Image Based Postural Assessment) The SPSS 24.0 program was used to analyze the data, and the following statistical tests were applied: chi squared, Mann-Whitney, Fisher’s exact and binary logistic regression. Results: There was statistical significance between hyperlordosis, girls’ age and puberty in boys (p 0.05). Conclusion: The girls’ age and boys’ stage of puberty were associated with the occurrence of hyperlordosis.Introdução: A Hiperlordose lombar pode ocasionar diversas patologias degenerativas na coluna vertebral de crianças e adolescentes. Objetivo: Identificar se o ĂŤndice de Massa Corporal, a Idade e a Maturação Sexual sĂŁo previsores da ocorrĂŞncia da hiperlordose lombar em crianças e adolescentes. MĂ©todo: O estudo analisou 380 estudantes entre 10 e 18 anos. O ĂŤndice de Massa Corporal foi avaliado por meio dos valores de referĂŞncia sugeridos pela bateria de testes Fitnessgram e a maturação sexual por meio da auto-avaliação da pilosidade pubiana de Tanner. A avaliação postural foi realizada pelo mĂ©todo de fotogrametria DIPA versĂŁo 3.1. (Avaliação Postural Baseada em Imagem Digital). Para análise dos dados foi utilizado o programa SPSS 24.0, tendo sido aplicados os testes estatĂsticos: Qui-Quadrado, Mann Whitney, Exato de Fisher e RegressĂŁo LogĂstica Binária. Resultados: Observou-se que houve significância estatĂstica entre a Hiperlordose lombar e a idade das meninas e a puberdade dos meninos (p0,05). ConclusĂŁo: A idade das meninas e a puberdade dos meninos foi associada Ă ocorrĂŞncia da hiperlordose lombar.This study was funded by CIEC (Center for
Investigations in Childhood Studies), Strategic Project
UID/CED/00317/2013, via National FCT (Science and
Technology Foundation) funds and co-funded by the
European Regional Development Fund (FEDER), via
COMPETE 2020 – Competitivity and Internalization
Operational Program (POCI) under reference number
POCI-01-0145-FEDER-007562
Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
Multiple Signals Converge on a Differentiation MAPK Pathway
An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions. To identify new aspects of filamentous growth regulation, we used a novel screening approach (called secretion profiling) that measures release of the extracellular domain of Msb2p, the signaling mucin which functions at the head of the filamentous growth (FG) MAPK pathway. Secretion profiling of complementary genomic collections showed that many of the pathways that regulate filamentous growth (RAS, RIM101, OPI1, and RTG) were also required for FG pathway activation. This regulation sensitized the FG pathway to multiple stimuli and synchronized it to the global signaling network. Several of the regulators were required for MSB2 expression, which identifies the MSB2 promoter as a target “hub” where multiple signals converge. Accessibility to the MSB2 promoter was further regulated by the histone deacetylase (HDAC) Rpd3p(L), which positively regulated FG pathway activity and filamentous growth. Our findings provide the first glimpse of a global regulatory hierarchy among the pathways that control filamentous growth. Systems-level integration of signaling circuitry is likely to coordinate other regulatory networks that control complex behaviors