13 research outputs found
Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation.
Get PDFApolipoprotein E (APOE) genotype determines Alzheimer\u27s disease (AD) susceptibility, with the APOE ε4 allele being an established risk factor for late-onset AD. The ApoE lipidation status has been reported to impact amyloid-beta (Aβ) peptide metabolism. The details of how lipidation affects ApoE behavior remain to be elucidated. In this study, we prepared lipid-free and lipid-bound ApoE particles, mimicking the high-density lipoprotein particles found in vivo, for all three isoforms (ApoE2, ApoE3, and ApoE4) and biophysically characterized them. We find that lipid-free ApoE in solution has the tendency to aggregate in vitro in an isoform-dependent manner under near-physiological conditions and that aggregation is impeded by lipidation of ApoE
Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue.
No full textApolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation
No full textRole of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review
No full textThe Use of Freeze-Fracture and Freeze-Etching Electron Microscopy for Phase Analysis and Structure Determination of Lipid Systems
No full textAlterations in lipoprotein density classes in infantile visceral Leishmaniasis: presence of apolipoprotein SAA
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