COMPARATIVE STUDY OF CLINICOPATHOLOGICAL FEATURES AND PROGNOSIS IN TRIPLE NEGATIVE AND NON-TRIPLE NEGATIVE BREAST CANCER IN THE NORTH OF MOROCCO

Breast cancer is a heterogeneous disease that can be classified into diverse subtypes with distinct biology and prognosis. The purpose of this study is to compare clinicopathological features and prognostic of patients with Triple Negative Breast Cancer (TNBC) and non-TNBC. Clinicopathological features and prognosis of 266 patients from north Morocco (56 TNBC and 210 non-TNBC) were evaluated using SPSS 20 software. The incidence of TNBC was 21%. Comparedwith non-TNBC, TNBC patients tend to be younger at diagnosis and had slightly larger tumors and higher stage. Higher histological grade was strongly associated with TNBC. Lymph nodes and histological type were similar in the two groups. Bone was the most frequently metastatic site in all breast cancers, but TNBC was strongly associated with liver metastases.No significant difference was observed in 5-year Disease-Free Survival (DFS) and 5-year Overall Survival (OS) between TNBC and non-TNBC. In conclusion, TNBC is associated with particular clinicopathological features and poor prognosis compared to non-TNBC

Effets endogamiques sur la germination et la croissance de semis du cultivar autocompatible Tuono (

Introduction. Des géniteurs d'amandiers autocompatibles ont souvent été utilisés pour introduire le caractère d'autocompatibilité dans leur descendance. Cependant, lors de tels programmes de création variétale, des problèmes de germination des graines obtenues et des difficultés de survie des jeunes plants ont été mis en évidence. L'objectif des travaux réalisés a été de quantifier les effets de la consanguinité sur certaines caractéristiques du développement des semences issues de tels géniteurs. Matériel et méthodes. Les descendances de la variété autocompatible Tuono autofécondée ou croisée avec des géniteurs mâles génétiquement éloignés ont été suivies et comparées, de la germination à l'âge de 3 ans. Les taux de germination, de levée et la vitesse de levée ont été évalués. Puis la croissance des plants a été étudiée à partir de la mesure régulière du diamètre de l'axe et de la hauteur des plants. Le nombre de nœuds, d'entre-nœuds, de rameaux anticipés et le taux de mortalité des plantules ont également été notés. Résultats. Par rapport aux semences issues d'allopollinisation, les graines issues d'autofécondation ont présenté un taux de germination moyen inférieur (61 % contre 81 %) ; la vigueur de leurs plantules, leur croissance radiale et apicale et le nombre de rameaux anticipés formés ont été plus faibles ; leur taux de mortalité a été supérieur (28 % contre 0,6 %). Discussion et conclusion. Les anomalies mises en évidence au cours de ces travaux seraient dues à l'endogamie et liées à l'accumulation de gènes défavorables dans la descendance consanguine

Clinicopathologic and prognostic features of breast cancer in young women: a series from North of Morocco

Abstract Background Literature data reported a higher frequency of breast cancer in young women (BCYW) in developing countries. BCYW is associated with delayed diagnosis, aggressive biology and poor prognosis. However, our knowledge of biological profile, treatment received and outcome of young patients is still limited in Morocco. We propose to analyze clinicopathologic, therapeutic and prognostic features of BCYW among a series of patients native and/or inhabitant of North of Morocco. Methods We carried out a retro-prospective study of 331 infiltrating breast cancer cases registered between January 2010 and December 2015. Details of tumor pathology, treatment and outcome were collected. Disease-Free Survival (DFS) and Overall Survival (OS) were assessed by Kaplan-Meier analysis. Results A total of 82 patients were diagnosed with breast cancer at the age of 40 or younger (24.8%). Median age was 36 years. More than one quarter (26%) of patients had family history of breast or ovarian cancer. Advanced stages accounted for 34.2% of cases. Median tumor diameter was 2.8 cm. Intermediate and high-grade tumors represented 47.6% and 40.2%, respectively. Nodal involvement was present in 58.5% and lymphovascular invasion was found in 47.7% of the patients. About two thirds (66.2%) of tumors were hormone receptor positive, 29.2% over-expressed HER2 receptor and 23% were triple negative. Patients underwent breast conserving surgery in 38.2% of cases, 61.7% were offered adjuvant chemotherapy and 84.6% received hormone therapy. Five-year DFS and OS were respectively 88.9% and 75.6%. Locoregional recurrence occurred in 2.8% of cases and 8.3% of patients developed distant metastases. Conclusion Our findings are in accordance with previous studies that have shown a higher frequency of breast cancer among Moroccan young women. In line with literature data, clinicopathologic profile seems to be aggressive and prognosis is pejorative in our series