Morphologic and systemic alterations in obese and overweight subjects after a physical activity intervention program

There are some evidences that exercise training reduces total and abdominal fat and some systemic variables with improve health benefits. The sim of this study was to ana1yse the variation of some morphologic and systemic variables in 16 (age-64.5±7.2) obese and overweight (BM!=31.4o±5.7) type 2 diabetic patieots, of hoth gender, dutiog a regular physical exercisc program, which consists of 3 5 minutes of fast walking every days of the week, during 8 months, and no diet intervention

A Hand Full of Numbers: A Role for Offloading in Arithmetics Learning?

Finger counting has been associated to arithmetic learning in children. We examined children with (n = 14) and without (n = 84) mathematics learning difficulties with ages between 8 and 11 years. Deficits in finger gnosia were found in association to mathematical difficulties. Finger gnosia was particularly relevant for the performance in word problems requiring active manipulation of small magnitudes in the range between 1 and 10. Moreover, the deficits in finger gnosia could not be attributed to a shortage in working memory capacity but rather to a specific inability to use fingers to transiently represent magnitudes, tagging to be counted objects, and reducing the cognitive load necessary to solve arithmetic problems. Since finger gnosia was more related to symbolic than to non-symbolic magnitude processing, finger-related representation of magnitude seems to be an important link for learning the mapping of analog onto discrete symbolic magnitudes

SAÚDE MENTAL DOS PROFISSIONAIS DE ENFERMAGEM QUE ATUAM NA LINHA DE FRENTE DA COVID-19: REVISÃO LITERÁRIA

Covid-19 had a great impact on the daily life of nursing professionals, being a major public health problem, professionals are essential in the application of the care provided to the patient using the know-how with excellence; Objective: to analyze the impact on the mental health of nursing professionals who work at the front line of Covid-19. Methods: this is an integrative literature review, prepared with articles from the Latin American Caribbean Literature in Health Sciences and Medical Literature Analysis and Retrieval System Online databases, and from the Scientific Electronic Library Online library; Results: seven articles published between 2020 and 2021 were selected. These presented the impacts on the mental health of nursing professionals in coping with Covid-19; Conclusion: when it comes to the spread of Covid-19, the nursing professional exercises his profession in the care of excellence provided to the patient in the context of work, requiring resolution in the midst of the problems presented.A Covid-19 teve um grande impacto no cotidiano dos profissionais de enfermagem, sendo um grande problema de saúde pública, os profissionais são essenciais na aplicação dos cuidados prestados ao paciente utilizando o saber-fazer com excelência; Objetivo: analisar o impacto na saúde mental dos profissionais de enfermagem que atuam na linha de frente da Covid-19. Métodos: trata-se de revisão integrativa da literatura, elaborada com artigos oriundos das bases de dados Literatura Latino-americana do Caribe em Ciências da Saúde e Medical Literature Analysis and Retrieval System Online, e da biblioteca Scientific Eletronic Library Online; Resultados: sete artigos publicados  entre 2020 e 2021 foram selecionados. Esses apresentaram os impactos na saúde mental dos profissionais de enfermagem no enfrentamento da Covid-19; Conclusão: tratando-se da propagação da Covid-19, o profissional de enfermagem exerce sua profissão no cuidado de excelência prestada ao paciente no âmbito do trabalho, sendo necessário resolutividade em meio às problemáticas apresentadas

Contributions from specific and general factors to unique deficits: two cases of mathematics learning difficulties

Mathematics learning difficulties are a highly comorbid and heterogeneous set of disorders linked to several dissociable mechanisms and endophenotypes. Two of these endophenotypes consist of primary deficits in number sense and verbal numerical representations. However, currently acknowledged endophenotypes are underspecified regarding the role of automatic vs. controlled information processing, and their description should be complemented. Two children with specific deficits in number sense and verbal numerical representations and normal or above-normal intelligence and preserved visuospatial cognition illustrate this point. Child H.V. exhibited deficits in number sense and fact retrieval. Child G.A. presented severe deficits in orally presented problems and transcoding tasks. A partial confirmation of the two endophenotypes that relate to the number sense and verbal processing was obtained, but a much more clear differentiation between the deficits presented by H.V. and G.A. can be reached by looking at differential impairments in modes of processing. H.V. is notably competent in the use of controlled processing but has problems with more automatic processes, such as nonsymbolic magnitude processing, speeded counting and fact retrieval. In contrast, G.A. can retrieve facts and process nonsymbolic magnitudes but exhibits severe impairment in recruiting executive functions and the concentration that is necessary to accomplish transcoding tasks and word problem solving. These results indicate that typical endophenotypes might be insufficient to describe accurately the deficits that are observed in children with mathematics learning abilities. However, by incorporating domain-specificity and modes of processing into the assessment of the endophenotypes, individual deficit profiles can be much more accurately described. This process calls for further specification of the endophenotypes in mathematics learning difficulties

Offshore 1755 CE Lisbon Tsunami deposit in the southern portuguese continental shelf

The importance of tsunami hazard assessment is only possible if a complete dataset of events is available, allowing the determination of the recurrence intervals of the tsunamis adapted to local and regional conditions. One possible way to know these intervals is to study the offshore sedimentary record, looking for sediment remobilised and transported by the incoming tsunami waves and generated backwash currents. Even if these deposits are not of easy access (and not so well studied), the tsunami depositional signature has potential to be better preserved than those located onshore.info:eu-repo/semantics/publishedVersio

Effects of anastrozole on Ki-67 antigen expression in the vaginal epithelium of female rats in persistent estrus

OBJECTIVES: Aromatase inhibitors are the first-choice drugs for the treatment of hormone sensitive breast cancer. However, in addition to the scarcity of studies, there are controversies about their effects on vaginal epithelial cell proliferation in rats, especially those in persistent estrus. METHODS: To investigate vaginal epithelial cell proliferation by Ki-67 antigen expression, persistent estrus was induced in 42 randomly selected rats. These rats were randomly divided into 2 groups: group I (control, n=21), which received 0.1 mL of propylene glycol (vehicle) daily, and group II (experimental, n=21), which received 0.5 mg/kg or 0.125 mg/day of anastrozole diluted with 0.1 mL of propylene glycol. RESULTS: Light microscopy showed a higher concentration of cells with brown Ki-67 stained nuclei in the control compared to the experimental group. The mean percentage of Ki-67 stained nuclei per 500 cells in the vaginal epithelium was 68.64±2.64 and 30.46±2.00 [mean±standard error of the mean (SEM)] in the control and experimental groups, respectively (po0.003). CONCLUSION: This study showed that anastrozole, at the dose and treatment duration selected, significantly decreased cell proliferation in the vaginal mucosa of the rats in persistent estrus

OMICs approaches in diarrhetic shellfish toxins research

ReviewDiarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis. This group of toxins, constituted by okadaic acid (OA) and analogous molecules (dinophysistoxins, DTXs), are highly harmful to humans, causing severe poisoning symptoms caused by the ingestion of contaminated seafood. Knowledge on the mode of action and toxicology of OA and the chemical characterization and accumulation of DSTs in seafood species (bivalves, gastropods and crustaceans) has significantly contributed to understand the impacts of these toxins in humans. Considerable information is however missing, particularly at the molecular and metabolic levels involving toxin uptake, distribution, compartmentalization and biotransformation and the interaction of DSTs with aquatic organisms. Recent contributions to the knowledge of DSTs arise from transcriptomics and proteomics research. Indeed, OMICs constitute a research field dedicated to the systematic analysis on the organisms’ metabolisms. The methodologies used in OMICs are also highly e ective to identify critical metabolic pathways a ecting the physiology of the organisms. In this review, we analyze the main contributions provided so far by OMICs to DSTs research and discuss the prospects of OMICs with regard to the DSTs toxicology and the significance of these toxins to public health, food safety and aquacultureinfo:eu-repo/semantics/publishedVersio

Analysis of the Ki-67 index in the vaginal epithelium of castrated rats treated with tamoxifen

OBJECTIVES: Vaginal atrophy and breast cancer are common conditions in postmenopausal women and tamoxifen is the standard endocrine treatment for hormone-sensitive tumors. The present study aimed to assess the effect of tamoxifen on Ki-67 protein expression in the vaginal epithelium of castrated rats. MATERIAL AND METHODS: Forty Wistar-Hannover adult, virgin, castrated rats were randomly divided into two groups, group I (control, n=20) and group II (tamoxifen, n=20), receiving 0.5 ml of propylene glycol and 250 µg of tamoxifen diluted in 0.5 ml of propylene glycol, respectively, daily by gavage for 30 days. On the 31st day, the rats were euthanized and their vaginas were removed and fixed in 10% buffered formalin for the immunohistochemical study of Ki-67 protein expression. Data were analyzed by the Levene and Student’s t tests (

A abordagem inicial do Trauma Cranioencefálico em crianças e idosos para o cirurgião geral no cenário do trauma: uma revisão de literatura: The initial approach to Head Trauma in children and the elderly for the general surgeon in the trauma setting: a literature review

O Traumatismo Cranioencefálico (TCE) é uma lesão cerebral estrutural resultante de uma força física externa transmitida à cabeça, o objetivo principal do tratamento dos doentes com suspeita de TCE grave é prevenir a lesão cerebral secundária. Como foco do estudo da revisão proposta, objetiva-se compreender o TCE como uma das principais causas de incapacidade a longo prazo entre crianças e pacientes geriátricos. A idade do paciente e o estado geral de saúde influenciam no prognóstico, com maior risco de morbidade e mortalidade associado ao trauma cranioencefálico em pacientes idosos. A presença de TCE em pacientes pediátricos merece grande atenção e importância, principalmente por suas peculiaridades, desafios e dificuldades no manejo

Internações por neoplasia maligna do colo do útero em Goiás no período de 2008 a 201

Introdução: O câncer do colo do útero é o segundo tumor mais frequente entre as mulheres, segundo o Instituto Nacional de Câncer (INCA). É um câncer que evolui lentamente, dessa forma, é necessário analisar de forma crítica como o fator faixa etária (FE) influencia nas taxas de internações pela neoplasia, a fim de evidenciar, por exemplo, em qual idade a prevalência da doença é maior. Isso porque afeta a incidência e a prevalência das internações. Assim, é imprescindível conhecer de forma objetiva os dados e análises sobre a influência desse fator nas taxas de internações. Objetivo: Avaliar a relação entre a faixa etária e o número de internações por neoplasia maligna do colo do útero em Goiás (GO) no período de jan/2008 a dez/2018, sob uma perspectiva crítica. Material e método: Trata-se de um estudo epidemiológico das séries temporais das taxas de internações por neoplasia maligna do colo do útero entre mulheres em Goiás (GO), no período de jan/2008 a dez/2018. O estudo estratificou as taxas de internações em cinco faixas-etárias: 20 a 29 anos, 30 a 39 anos, 40 a 49 anos, 50 a 59 anos e 60 ou mais anos. Os dados da pesquisa foram obtidos através do Sistema de Internações Hospitalares (SIH) e pela Rede Interagencial de Informações para a Saúde (RIPSA), para estimativas de população. Para a análise de conteúdo dos dados obtidos foi utilizado o método de Prais-Winsten. Resultados: Foram analisadas 6440 internações entre jan/2008 e dez/2018. A FE com maior número de internações foi a de 40 a 49 anos com 2502 (38,8%) e a com menor número foi entre 20 a 29 anos com 262 (4%) internações. A prevalência de mulheres internadas foi de 0,3% e a taxa de óbito foi de 8,63. As taxas de internações a cada 100.000 mulheres, em ordem crescente dos anos analisados, começando em 2008 e terminando em 2018, foram as seguintes: 37,8; 49; 42; 32; 26,6; 19; 18,4; 17,2; 15,8; 19 e 24. Dessa forma, o ano com maior taxa foi 2009 com 49/100.000 mil mulheres e apesar de 2008 ter 37/100.000 e 2018 ter 24/100.000, a tendência temporal da taxa é estacionária (bvalor = - 0,15; p-valor = 0.144). Conclusão: O estudo mostrou que, no estado de Goiás, a FE com o maior índice de internação por CA do colo uterino foi entre 40 e 49 anos e a com menor incidência foi entre 20 e 29 anos. O resultado corrobora com a literatura, pois o câncer do colo de útero é raro em mulheres até 30 anos e o pico de incidência é entre 45 a 50 anos. A diminuição do número de internações ao longo do tempo, com um leve aumento em 2017 e 2018, mas substancialmente menor do que em 2008, pode significar melhoria no rastreio e no manejo dessa doença na atenção básica. Porém, mesmo com uma possível melhora na prevenção, as taxas de internações mostram-se estacionárias, o que nos remete a necessidade de políticas públicas mais eficazes para prevenção e promoção de saúde, principalmente na FE mais acometida