759 research outputs found

    IKS Is Activated By Both Ca2+ Dependent And Independent Isoforms Of PKC

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    The world-sheet corrections to dyons in the Heterotic theory

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    All the linear alpha-prime corrections, however excluding the gravitational Chern-Simons correction, are studied in the toroidally compactified critical Heterotic string theory. These corrections are computed to the entropy for a BPS static spherical four dimensional dyonic black hole which represents a wrapped fundamental string carrying arbitrary winding and momentum charges along one cycle in the presence of KK-monopole and H-monopole charges associated to another cycle. It is verified that after the inclusion of the gravitational Chern-Simons corrections [hep-th/0608182], all the linear alpha-prime corrections to the entropy for the supersymmetric dyon can be reproduced by the inclusion of only the Gauss-Bonnet Lagrangian to the supergravity approximation of the induced Lagrangian.Comment: JHEP style, 17 Pages; v2: a typo corrected ; v3: The coupling of the gravitational Chern-Simons terms to the three form field strength taken into account. The conclusion correcte

    Higher Derivative Corrections to Eleven Dimensional Supergravity via Local Supersymmetry

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    In this paper we derive higher derivative corrections to the eleven dimensional supergravity by applying the Noether method with respect to the N=1 local supersymmetry. An ansatz for the higher derivative effective action, which includes quartic terms of the Riemann tensor, is parametrized by 132 parameters. Then we show that by the requirement of the local supersymmetry, the higher derivative effective action is essentially described by two parameters. The bosonic parts of these two superinvariants completely match with the known results obtained by the perturbative calculations in the type IIA superstring theory. Since the calculations are long and systematic, we build the computer programming to check the cancellation of the variations under the local supersymmetry. This is an extended version of our previous paper hep-th/0508204.Comment: 67 pages, no figure, references added, typos correcte

    Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.

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    Protein kinase C (PKC) plays key roles in the regulation of signal transduction and cellular function in various cell types. At least ten PKC isoforms have been identified and intracellular localization and trafficking of these individual isoforms are important for regulation of enzyme activity and substrate specificity. PKC can be activated downstream of Gq-protein coupled receptor (GqPCR) signaling and translocate to various cellular compartments including plasma membrane (PM). Recent reports suggested that different types of GqPCRs would activate different PKC isoforms (classic, novel and atypical PKCs) with different trafficking patterns. However, the knowledge of isoform-specific activation of PKC by each GqPCR is limited. α1-Adrenoceptor (α1-AR) is one of the GqPCRs highly expressed in the cardiovascular system. In this study, we examined the isoform-specific dynamic translocation of PKC in living HEK293T cells by α1-AR stimulation (α1-ARS). Rat PKCα, βI, βII, δ, ε and ζ fused with GFP at C-term were co-transfected with human α1A-AR into HEK293T cells. The isoform-specific dynamic translocation of PKC in living HEK293T cells by α1-ARS using phenylephrine was measured by confocal microscopy. Before stimulation, GFP-PKCs were localized at cytosolic region. α1-ARS strongly and rapidly translocated a classical PKC (cPKC), PKCα, (\u3c30 \u3es) to PM, with PKCα returning diffusively into the cytosol within 5 min. α1-ARS rapidly translocated other cPKCs, PKCβI and PKCβII, to the PM (\u3c30 \u3es), with sustained membrane localization. One novel PKC (nPKC), PKCε, but not another nPKC, PKCδ, was translocated by α1-AR stimulation to the PM (\u3c30 \u3es) and its membrane localization was also sustained. Finally, α1-AR stimulation did not cause a diacylglycerol-insensitive atypical PKC, PKCζ translocation. Our data suggest that PKCα, β and ε activation may underlie physiological and pathophysiological responses of α1-AR signaling for the phosphorylation of membrane-associated substrates including ion-channel and transporter proteins in the cardiovascular system

    Heterotic String Compactifications on Half-flat Manifolds II

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    In this paper, we continue the analysis of heterotic string compactifications on half-flat mirror manifolds by including the 10-dimensional gauge fields. It is argued, that the heterotic Bianchi identity is solved by a variant of the standard embedding. Then, the resulting gauge group in four dimensions is still E6 despite the fact that the Levi-Civita connection has SO(6) holonomy. We derive the associated four-dimensional effective theories including matter field terms for such compactifications. The results are also extended to more general manifolds with SU(3) structure.Comment: 31 page

    Fermion Zero Modes in the Presence of Fluxes and a Non-perturbative Superpotential

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    We study the effect of background fluxes of general Hodge type on the supersymmetry conditions and on the fermionic zero modes on the world-volume of a Euclidean M5/D3-brane in M-theory/type IIB string theory. Using the naive susy variation of the modulino fields to determine the number of zero modes in the presence of a flux of general Hodge type, an inconsistency appears. This inconsistency is resolved by a modification of the supersymmetry variation of the modulinos, which captures the back-reaction of the non-perturbative effects on the background flux and the geometry.Comment: 21 pages, revised version contains a new appendix on dimensional reduction of spinors and some changes in the spinor equation

    Two-charge small black hole entropy: String-loops and multi-strings

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    We investigate the inclusion of 10-dimensional string loop corrections to the entropy function of two-charge extremal small black holes of the heterotic string theory compactified on S^1 x T^5 and show that the entropy is given by \pi\sqrt{a q_1 q_2+b q_1} where q_1 and q_2 are the charges with q_1 >> q_2 >> 1 and a and b are constants. Incorporating certain multi-string states into the microstate counting, we show that the new statistical entropy is consistent with the macroscopic scaling for one and two units of momentum (winding) and large winding (momentum). We discuss our scaling from the point of view of related AdS_3 central charge and counting of chiral primaries in superconformal quantum mechanics as well.Comment: 18 page

    One-loop Correction and the Dilaton Runaway Problem

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    We examine the one-loop vacuum structure of an effective theory of gaugino condensation coupled to the dilaton for string models in which the gauge coupling constant does not receive string threshold corrections. The new ingredients in our treatment are that we take into account the one-loop correction to the dilaton K\"ahler potential and we use a formulation which includes a chiral field HH corresponding to the gaugino bilinear. We find through explicit calculation that supersymmetry in the Yang-Mills sector is broken by gaugino condensation. The dilaton and HH field have masses on the order of the gaugino condensation scale independently of the dilaton VEV. Although the calculation performed here is at best a model of the full gaugino condensation dynamics, the result shows that the one-loop correction to the dilaton K\"ahler potential as well as the detailed dynamics at the gaugino condensation scale may play an important role in solving the dilaton runaway problem.Comment: 19 page

    Fundamental Superstrings as Holograms

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    The worldsheet of a macroscopic fundamental superstring in the Green-Schwarz light-cone gauge is viewed as a possible boundary hologram of the near horizon region of a small black string. For toroidally compactified strings, the hologram has global symmetries of AdS_3 \times S^{d-1} \times T^{8-d}, (d =3,..,8), only some of which extend to local conformal symmetries. We construct the bulk string theory in detail for the particular case of d=3. The symmetries of the hologram are correctly reproduced from this exact worldsheet description in the bulk. Moreover, the central charge of the boundary Virasoro algebra obtained from the bulk agrees with the Wald entropy of the associated small black holes. This construction provides an exact CFT description of the near horizon region of small black holes both in Type-II and heterotic string theory arising from multiply wound fundamental superstrings.Comment: 46 pages, JHEP style. v2: Comments, references adde
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