11 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
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- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
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- Antonishen D
- Antonishen M
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- Appel S
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- Baigent C
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- Zhao L
- Zhao P
- Zhao R
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- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
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- Ziefle S
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- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ă…gĂĄrdh A
- Ă–ner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Prevalence, awareness, treatment, and control of hypertension in older people: results from the population-based KORA-age 1 study
- Author
- A Benetos
- A Peters
- A Tamhane
- AG Johnson
- B Williams
- BM Egan
- BN Mukete
- C Diederichs
- CM Murphy
- E Grill
- E Pinto
- GA Roth
- H Neuhauser
- H Neuhauser
- I Kirchberger
- KT Mills
- LM Goeres
- LSE Seow
- M McDonald
- ME Lacruz
- MH Forouzanfar
- P Brindel
- P Salvi
- R Gobbens
- R Malhotra
- R Peters
- S Makin
- S Steigerwalt
- T Oshio
- T Zdrojewski
- TW Buford
- WB White
- Y Ostchega
- YC Tsai
- Z Bursac
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Medication Use and Fall-Related Hospital Admissions from Long-Term Care Facilities: A Hospital-Based Case–Control Study
- Author
- A Benetos
- A Cherubini
- A Cherubini
- A Tovell
- B Leung
- BC Sun
- BC Wimmer
- Biswadev Mitra
- C Bavishi
- C Bradley
- C Bradley
- Carl M. Kirkpatrick
- CJ Mann
- CS Eom
- CS Sterke
- D O’Mahony
- DL Groll
- Elizabeth Manias
- F Baranzini
- F Ricci
- H Park
- J Damián
- J Olazarán
- J. Simon Bell
- JC Woolcott
- Jenni Ilomäki
- JK Sluggett
- JP Turner
- JW Wastesson
- K Ruxton
- KJ Rothman
- LA Lipsitz
- LM Goeres
- LM Kalisch
- LZ Rubenstein
- Michael J. Dooley
- Mieke Hutchinson-Kern
- ML Callisaya
- MQ Vu
- N Jokanovic
- N Jokanovic
- NL Pratt
- S Hartikainen
- S Heinrich
- S Jansen
- S Lalic
- SD Berry
- SE Bronskill
- SN Hilmer
- Susan G. Poole
- Taliesin E. Ryan-Atwood
- V Milos
- WB Runciman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The use of magnesium peroxide for the inhibition of sulfate-reducing bacteria under anoxic conditions
- Author
- A Loy
- A Rinzema
- AM Sass
- BE Duffy
- C Hubert
- Chun-Hsiung Hung
- CM Kao
- CM Santegoeds
- D Krekeler
- D Lyew
- D Schäfer
- DA Stahl
- DC Buzea
- DM Goeres
- EW Alm
- EW Flick
- F Vester
- FH Chapelle
- G Gottschalk
- G Voordouw
- G Wallner
- H Cypionka
- HT Dinh
- I Davidova
- JR Postgate
- LM Prescott
- LW Hulshoff Pol
- M Nemati
- M Nemati
- M Tomar
- R Amann
- R Marchal
- RE Hicks
- RI Amann
- RI Amann
- RM Maier
- S Delgado
- S Okabe
- SK Khanal
- SW Poulton
- T Schmidtke
- T Yamanaka
- W Manz
- W Manz
- WA Hamilton
- WP Iverson
- Y-J Chang
- Y-J Chang
- Yi-Tang Chang
- Yu-Jie Chang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
- Author
- A Bonnet
- A Flotho
- A Lewis
- A Mehta
- A Subramanian
- AC Tuck
- AG Floch
- B Palancade
- B Palancade
- BM Webster
- D Flemming
- DJ Hogan
- DR Mackay
- E McShane
- E Natan
- EA Powrie
- F Pelisch
- GW Li
- H Bretes
- H Hieronymus
- H Hirano
- H Lempiainen
- HD Ulrich
- J Goeres
- J Hang
- JC Rosenbaum
- JJ Wolf
- JO Rouviere
- JW Harper
- K Irie
- K Kim Guisbert
- L Texari
- LA Strawn
- LI Davis
- LM Starita
- M Beck
- M Garcia-Dominguez
- M Marelli
- M Weberruss
- MK Sung
- MT Vassileva
- N Belgareh
- N Dephoure
- N Paquin
- NL Schlaich
- NN Fang
- P Colombi
- P Grandi
- R Bruderer
- R Takemura
- RY Hampton
- S Izawa
- S Wolff
- SJ Li
- SJ Li
- SJ Li
- SW Lee
- T Li
- T Makhnevych
- T Makio
- T Srikumar
- TL Bailey
- U Rothenbusch
- VG Panse
- W Ito
- X Zhao
- Y Arava
- Y Hasegawa
- Y Sydorskyy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multimorbidity and complex multimorbidity in Brazilian rural workers
- Author
- A Feely
- A Frølich
- A Miles
- AEP Lourenço
- AG Jantsch
- Associação Brasileira de Empresas de Pesquisa
- AY Chang
- BM Holzer
- BP Nunes
- BP Nunes
- BP Nunes
- C Hajat
- C Harrison
- C Harrison
- C Harrison
- C Madlock-Brown
- C Violan
- C Violán
- CB Agborsangaya
- CS Costa
- D Newman
- DC Malta
- Eliana Zandonade
- EM Woldesemayat
- F Prazeres
- Glenda Blaser Petarli
- GQ Romana
- H Chen
- H Nguyen
- HP Booth
- HT Xavier
- J Macinko
- J Upadhyay
- JM Abad-DĂez
- JN Carvalho
- JT Lee
- KC Roberts
- KH Kim
- LAC Lobo
- LM Goeres
- Luciane Bresciani Salaroli
- M van den Akker
- MA Hussain
- MJ Divo
- Monica Cattafesta
- Monike Moreto Sant’Anna
- MT Puth
- N Garin
- N Garin
- NV Ba
- OlĂvia Maria de Paula Alves Bezerra
- P Amorim
- R Ofori-Asenso
- R Palladino
- R Palladino
- R Zhang
- RN Kuo
- S Afshar
- S Agrawal
- S Pengpid
- SG Guerra
- Siew Ann Cheong
- SKK Aye
- Sociedade Brasileira de Cardiologia
- Sociedade brasileira de cardiologia
- TI Pathirana
- W Pickett
- World Health Organization
- World Health Organization
- X Li
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Biofilm-Related Periprosthetic Joint Infections
- Author
- A Buret
- A Gaudin
- A Tate
- AG Gristina
- AM Stephen
- B Chiu
- B Li
- BD Owens
- C Brandt
- CE ZoBell
- CG Zalazras
- CK Murray
- D Williams
- DE Fry
- DL Williams
- DL Williams
- DL Williams
- DL Williams
- DM Goeres
- DS Kaltsas
- DW Lambe
- E Hart
- EA Grice
- EN Johnson
- EW Lambert
- F Guarner
- G James
- G Zhao
- G-Y Zou
- GA James
- GG Geesey
- GL Simon
- H Ceri
- J Wimpenny
- JC Nickel
- JE Dohar
- JG Leid
- JG Thomas
- JL Connell
- JLD Pozo
- JO Hendley
- JR Lawrence
- JW Costerton
- JW Costerton
- JW Costerton
- JW Costerton
- K Okuda
- KJ Mayberry-Carson
- LK Hansen
- LM Feazel
- LR Bakken
- M Lucke
- MB Melchior
- MC Robson
- MO Elasri
- MY Krasko
- N Cerca
- N Fernandez-Hidalgo
- NM Bernthal
- O Cirioni
- PG Bowler
- PM Mertz
- PO Sponseller
- R Edwards
- RB Gustilo
- RB Gustilo
- RC Murphy
- RD Wolcott
- RM Donlan
- RO Darouiche
- RO Darouiche
- RO Darouiche
- RO Darouiche
- SC Davis
- SD Reid
- SE Dowd
- SL Percival
- T Marrie
- TGR Chou
- TJ Krizek
- V Antoci
- V Torsvik
- VW Serralta
- W Zimmerli
- WB Keeling
- WE Kloos
- YS Brin
- Z Xie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy
- Author
- A Casadevall
- A Huber
- A Weston
- Ali Vural
- Amélie Bernard
- B Levine
- BJ Park
- C Settembre
- CC Thoreen
- CL Lucas
- CR Bartholomew
- CS Shi
- D Teixeira
- D Zenklusen
- Daniel J. Klionsky
- DC Goeres
- DJ Hogan
- DJ Klionsky
- DP Riordan
- E de Castro
- G Hu
- GI Shulman
- Gulbu Uzel
- Guowu Hu
- H Sharif
- J Coller
- J Fullgrabe
- J Hardwick
- J Inacio
- J Panepinto
- J Vandesompele
- JC Panepinto
- JH Yoon
- Jin Qiu
- JJ Osterholzer
- John H. Kehrl
- K Schroder
- L Romero-Santacreu
- LM Iakoucheva
- M Feldmesser
- M Schlumpberger
- M Tsukada
- MA Freeberg
- MA Teste
- MP Ashe
- MS Longtine
- N Blom
- N Hay
- N Paquette
- Nannan Zhang
- Nathan H. Blewett
- NH Blewett
- NL Garneau
- P Rice
- PA Takizawa
- Peter R. Williamson
- PP Hsu
- R Overbeek
- Richard J. Maraia
- RS Gray
- S Nallamsetty
- Scott R. Waterman
- SD Salas
- SF Altschul
- T Dunckley
- T Ikenoue
- T Nissan
- T Shintani
- T Yorimitsu
- TF Chan
- Timothy G. Myers
- Travis McQuiston
- V Deretic
- V Presnyak
- VK Nagarajan
- W Fan
- X Liu
- X Zhu
- Y Feng
- Y Kabeya
- Y Kamada
- Y Li
- YH Wong
- Yoon-Dong Park
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection
- Author
- A Biggerstaff
- A Dell
- A Dupont
- A Everard
- A Kushmaro
- A Masuda
- A Oliver
- A Swidsinski
- A Toren
- A Wallberg
- AA Jatkar
- AD Dwarakanath
- AP Corfield
- AP Corfield
- AS Mall
- B Button
- BC Rossier
- BE Brown
- BO Schroeder
- BW Peterson
- C Atuma
- C Josenhans
- C Krembs
- C Nowald
- C Portal
- C Wild
- CA Kumamoto
- CG Kelly
- CH Clevers
- CL Bevins
- CV Robinson
- D Ambort
- D Beer de
- D Berry
- D Goeres
- D Kelman
- D Kelman
- DA Elphick
- DC Yoch
- DH Dube
- DL Chance
- DR Schneider
- E Slack
- EC McGrath
- EYT Chen
- F Bäckhed
- F Paulsen
- G O’Toole
- GA Duncan
- GC Hansson
- GG Martin
- H Li
- HW Ducklow
- I Paterson
- J Frias-Lopez
- J Kennedy
- J Kocevar-Nared
- J Madsen
- J Mendicino
- J Reunanen
- J Witten
- JC Bythell
- JD Powell
- JE Kerschner
- JH Bergström
- JK Gustafsson
- JL Desseyn
- JL Desseyn
- JM Rhodes
- JP Celli
- JP Celli
- JP Pearson
- JR Seymour
- JTD Leito
- K Kunzelmann
- K Outterson
- KI Wolska
- KM Ng
- L Chen
- L Smith
- L Stabili
- LC Hoskins
- LM Ensign
- M Boegh
- M Caldara
- M Daly
- M Derrien
- M Derrien
- M Derrien
- M Garren
- M Garren
- M Givskov
- M Kesimer
- M Slattery
- M Zanin
- MA Alrahman
- MA McGuckin
- MA Momoh
- MAS Garcia
- MC Rose
- MD Wilcox
- ME Johansson
- ME Johansson
- MF Moffatt
- MM Farberman
- MO Henke
- MW Hornef
- MWJ Passel van
- N Hayashi
- N Moniaux
- N Ohta
- N Ottman
- N Rädecker
- NL Kavanaugh
- NS Jakubovics
- NS Webster
- NV Whelan
- P Chaturvedi
- P Jollès
- P Messner
- P Radhakrishnan
- P Tardent
- PM Quinton
- PS Davies
- PS Stewart
- PS Stewart
- Q Luo
- R Bansil
- R Maximilien
- R O’Toole
- R Pinto
- R Rauh
- R Rodolfo-Metalpa
- RA Cone
- RJ Braun
- RP Cooney
- RR Hodges
- S Jakowska
- S Subramanian
- SE Harding
- SK Behera
- SK Lai
- T Iwai
- T Lang
- T Lang
- TD Ainsworth
- V Gouyer
- VL Murty
- W Goldstein
- XX Tang
- Y Geffen
- Y Itoh
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 04/07/2018
- Field of study
Mucus layers often provide a unique and multi-functional hydrogel interface between the epithelial cells of organisms and their external environment. Mucus has exceptional properties including elasticity, changeable rheology and an ability to self-repair by reannealing, and is therefore an ideal medium for trapping and immobilising pathogens and serving as a barrier to microbial infection. The ability to produce a functional surface mucosa was an important evolutionary step, which evolved first in the Cnidaria, which includes corals, and the Ctenophora. This allowed the exclusion of non-commensal microbes and the subsequent development of the mucus-lined digestive cavity seen in higher metazoans. The fundamental architecture of the constituent glycoprotein mucins is also evolutionarily conserved. Although an understanding of the biochemical interactions between bacteria and the mucus layer are important to the goal of developing new antimicrobial strategies, they remain relatively poorly understood. This review summarises the physicochemical properties and evolutionary importance of mucus, which make it so successful in the prevention of bacterial infection. In addition, the strategies developed by bacteria to counteract the mucus layer are also explored
Comparative proteomic study of Arabidopsis mutants mpk4 and mpk6
- Author
- A Conesa
- A Linkies
- A Niehl
- A Pitzschke
- AC Doxey
- AF Fusaro
- B PĂ©ret
- C Heeg
- C Liu
- CLH Hord
- D Guo
- D Konopka-Postupolska
- DC Bergmann
- DC Goeres
- DM Rancour
- DY Sung
- EC McKinney
- F Baluska
- F Liu
- F Takahashi
- G Strompen
- G Winter
- GJM Beckers
- H Aebi
- H Dinkel
- H Jin
- H Renault
- I Lassowskat
- IK Jarsch
- J Colcombet
- J Guo
- J Li
- J Li
- J MĂĽller
- J Xu
- J-G Chen
- J-L Gallois
- JD Mayfield
- JS LĂłpez-Bucio
- JY Kim
- K Fujisaki
- K Kosetsu
- K Suzuki
- K Yamada
- K Yamada
- L Shen
- L Yu
- LAR Pereira
- LD Noël
- LJ Jensen
- LM Voll
- LU Gilliland
- M Abu-Abied
- M Beck
- M Beck
- M Chen
- M Gao
- M Petersen
- M Teige
- M Ueda
- M Uraji
- M Yang
- MA Hooks
- MF Suarez
- MK Deyholos
- MK Kandasamy
- MK Kandasamy
- MM Bradford
- N Frei dit Frey
- NL Taylor
- PJ Dufresne
- Q Zhang
- Q-P Sun
- R Chang
- R Matsushima
- R Perl-Treves
- R Porat
- S Berriri
- S Ishiguro
- S Matsumoto
- S Park
- S Park
- S Thitamadee
- S-C Park
- S-D Yoo
- S-G Hwang
- SC Popescu
- SM Bush
- SM Lee
- SY Kim
- T Asai
- T Murashige
- T Takáč
- T Takáč
- T Takáč
- T Vellosillo
- TE Gookin
- V Smékalová
- V Smékalová
- W Hoehenwarter
- X Ma
- X Meng
- X Yang
- Y Guo
- Y He
- Y Kovtun
- Y Liu
- Y Xing
- Y Xing
- Y Xing
- Y Xue
- Y-M Qin
- Z Cheng
- Z Hossain
- Ľ Uváčková
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study