69 research outputs found
A framework for exploring the sense of community and social life in residential environments
Sense of community and social life are two key concepts related to social cohesion, which have been the subject of extensive studies in several disciplines including sociology, psychology and built environment. Social life studies have been mostly conducted in the built environment discipline focusing on city centres; while sense of community studies were mostly the target of sociologists and psychologists focusing on neighbourhoods. As a result, the role of the built environment on the sense of community and social life of neighbourhoods is considered as a missing gap in the literature. This paper, through defining the concepts of social life and sense of community, aims to develop a conceptual framework for further implementation in future research. Accurate implication and interpretation of the concepts show that neighbourhoods can include the sense of community in the residential environment and the social life in the commercial environment. This is because residential environments are where residents\u27 requirements can be met through their commitment to the community and commercial environments are the fulcrum of interaction and communication
Prevalence of and factors affecting malocclusion in primary dentition among children in Xi’an, China
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
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